Aloxi Capsules

DRUG DESCRIPTION

ALOXI (palonosetron HCl) Capsules is an antiemetic and antinauseant agent. It is a serotonin subtype 3 (5-HT3) receptor antagonist with a strong binding affinity for this receptor. Chemically, palonosetron hydrochloride is: (3aS)-2-[(S)-1-Azabicyclo [2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1-oxo-1H-benz[de]isoquinoline hydrochloride. The empirical formula is C19H24N2O.HCl, with a molecular weight of 332.87. Palonosetron hydrochloride exists as a single isomer and has the following structural formula:

ALOXI (palonosetron HCl) Capsules Structural Formula Illustration

Palonosetron hydrochloride is a white to off-white crystalline powder. It is freely soluble in water, soluble in propylene glycol, and slightly soluble in ethanol and 2-propanol.

Each light beige opaque soft gelatin ALOXI (palonosetron hcl capsules) Capsule contains 0.56 mg of palonosetron HCl equivalent to palonosetron 0.5 mg. Inactive ingredients are: mono- and di-glycerides of capryl/capric acid, glycerin, polyglyceryl oleate, water, and butylated hydroxyanisole.

What are the possible side effects of palonosetron (Aloxi)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • fever;
  • slow or uneven heart rate, trouble breathing;
  • anxiety, agitation, shivering;
  • feeling light-headed, fainting; or
  • urinating less than usual or not at all.

Less serious side effects may include:

  • diarrhea;
  • ...

Read All Potential Side Effects and See Pictures of Aloxi Capsules


Aloxi Capsules Patient Information Including Side Effects

Brand Names: Aloxi

Generic Name: palonosetron (Pronunciation: PAL oh NOE se tron)

  • What is palonosetron (Aloxi Capsules)?
  • What are the possible side effects of palonosetron (Aloxi Capsules)?
  • What is the most important information I should know about palonosetron (Aloxi Capsules)?
  • What should I discuss with my health care provider before receiving palonosetron (Aloxi Capsules)?
  • How is palonosetron given (Aloxi Capsules)?
  • What happens if I miss a dose (Aloxi Capsules)?
  • What happens if I overdose (Aloxi Capsules)?
  • What should I avoid after receiving palonosetron (Aloxi Capsules)?
  • What other drugs will affect palonosetron (Aloxi Capsules)?
  • Where can I get more information?

What is palonosetron (Aloxi Capsules)?

Palonosetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Palonosetron is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy or radiation).

Palonosetron may also be used for other purposes not listed in this medication guide.

What are the possible side effects of palonosetron (Aloxi Capsules)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • fever;
  • slow or uneven heart rate, trouble breathing;
  • anxiety, agitation, shivering;
  • feeling light-headed, fainting; or
  • urinating less than usual or not at all.

Less serious side effects may include:

  • diarrhea;
  • constipation;
  • dizziness;
  • headache; or
  • tired feeling.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about palonosetron (Aloxi Capsules)?

You should not use this medication if you are allergic to palonosetron.

Before you receive palonosetron, tell your doctor if you have an electrolyte imbalance, a personal or family history of "Long QT syndrome," if you take a diuretic (water pill), or if you take a heart rhythm medication.

Tell your doctor if you have ever had an allergic reaction to dolasetron (Anzemet), granisetron (Kytril), or ondansetron (Zofran).

Call your doctor at once if you have uneven heartbeats while receiving palonosetron.

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