Mepron

DRUG DESCRIPTION

MEPRON (atovaquone) is an antiprotozoal agent. The chemical name of atovaquone is trans 2-[4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione. Atovaquone is a yellow crystalline solid that is practically insoluble in water. It has a molecular weight of 366.84 and the molecular formula C22H19ClO3. The compound has the following structural formula:

MEPRON®  (atovaquone) Structural Formula Illustration

MEPRON (atovaquone) Suspension is a formulation of micro-fine particles of atovaquone. The atovaquone particles, reduced in size to facilitate absorption, are significantly smaller than those in the previously marketed tablet formulation. MEPRON (atovaquone) Suspension is for oral administration and is bright yellow with a citrus flavor. Each teaspoonful (5 mL) contains 750 mg of atovaquone and the inactive ingredients benzyl alcohol, flavor, poloxamer 188, purified water, saccharin sodium, and xanthan gum.

Microbiology

Mechanism of Action: Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystis activity. The mechanism of action against Pneumocystis carinii has not been fully elucidated. In Plasmodium species, the site of action appears to be the cytochrome bc1 complex (Complex III). Several metabolic enzymes are linked to the mitochondrial electron transport chain via ubiquinone. Inhibition of electron transport by atovaquone will result in indirect inhibition of these enzymes. The ultimate metabolic effects of such blockade may include inhibition of nucleic acid and ATP synthesis.

Activity In Vitro: Several laboratories, using different in vitro methodologies, have shown the IC50 (50% inhibitory concentration) of atovaquone against rat P. carinii to be in the range of 0.1 to 3.0 mcg/mL.

Drug Resistance: Phenotypic resistance to atovaquone in vitro has not been demonstrated for P. carinii. However, in 2 patients who developed P. carinii pneumonia (PCP) after prophylaxis with atovaquone, DNA sequence analysis identified mutations in the predicted amino acid sequence of P. carinii cytochrome b (a likely target site for atovaquone). The clinical significance of this is unknown.

What are the possible side effects of atovaquone (Mepron)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • easy bruising or bleeding, unusual weakness;
  • fever, flu symptoms;
  • white patches in your mouth or throat;
  • worsening cough;
  • bronchospasm (wheezing, chest tightness, trouble breathing);
  • fever, sore throat, and headache with a severe blistering,...

Read All Potential Side Effects and See Pictures of Mepron »

What are the precautions when taking atovaquone (Mepron)?

Before taking atovaquone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: lung problems, liver disease, stomach disorders (e.g., long-term diarrhea, malabsorption syndrome).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your...

Read All Potential Precautions of Mepron »


Mepron Consumer (continued)

SIDE EFFECTS: Stomach upset/pain, nausea, vomiting, diarrhea, constipation, loss of appetite, headache, dizziness, trouble sleeping, fever, sweating, or a strange taste in the mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes (e.g., depression, anxiety), unusual weakness.

Tell your doctor immediately if any of these rare but very serious side effects occur: vision changes, change in the amount of urine, unusual bleeding/bruising, dark urine, yellowing eyes/skin, severe stomach/abdominal pain, persistent nausea/vomiting.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Atovaquone can commonly cause a mild rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe allergic reaction. Therefore, seek immediate medical attention if you develop any rash.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking atovaquone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: lung problems, liver disease, stomach disorders (e.g., long-term diarrhea, malabsorption syndrome).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.


Mepron Patient Information Including Side Effects

Brand Names: Mepron

Generic Name: atovaquone (Pronunciation: a TOE va kwone)

  • What is atovaquone (Mepron)?
  • What are the possible side effects of atovaquone (Mepron)?
  • What is the most important information I should know about atovaquone (Mepron)?
  • What should I discuss with my healthcare provider before taking atovaquone (Mepron)?
  • How should I take atovaquone (Mepron)?
  • What happens if I miss a dose (Mepron)?
  • What happens if I overdose (Mepron)?
  • What should I avoid while taking atovaquone (Mepron)?
  • What other drugs will affect atovaquone (Mepron)?
  • Where can I get more information?

What is atovaquone (Mepron)?

Atovaquone is a medication that interferes with the reproduction of protozoa (single-cell organisms) that can cause disease in the body.

Atovaquone is used to treat or prevent pneumonia caused by a fungal infection called Pneumocystitis carinii (also called Pneumocystis jiroveci).

Atovaquone may also be used for other purposes not listed in this medication guide.

What are the possible side effects of atovaquone (Mepron)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • easy bruising or bleeding, unusual weakness;
  • fever, flu symptoms;
  • white patches in your mouth or throat;
  • worsening cough;
  • bronchospasm (wheezing, chest tightness, trouble breathing);
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
  • nausea, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • mild nausea, vomiting, stomach pain or upset,
  • diarrhea, constipation;
  • headache;
  • weakness, dizziness;
  • muscle pain;
  • mild skin rash;
  • sweating; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about atovaquone (Mepron)?

You should not use this medication if you are allergic to atovaquone.

Before using this medication, tell your doctor if you have liver disease, or a stomach or intestinal disorder.

Also tell your doctor if you use other medications such as rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate, Rimactane), a blood thinner such as warfarin (Coumadin), or a seizure medication such as carbamazepine (Carbatrol, Tegretol), divalproex (Depakote), phenytoin (Dilantin), or valproic acid (Depakene).

Take atovaquone with a meal for best results.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated.

Call your doctor at once if you have a serious side effect such as easy bruising or bleeding, fever, flu symptoms, white patches in your mouth or throat, worsening cough, wheezing, trouble breathing, a severe red or peeling skin rash, or jaundice (yellowing of the skin or eyes).

Related Drug Centers
  • Mepron


Related Drugs Index: