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DRUG DESCRIPTION
Aminosyn® WITH ELECTROLYTES, Sulfite-Free, (a crystalline amino acid solution with electrolytes) is a sterile, nonpyrogenic solution for intravenous infusion. Aminosyn WITH ELECTROLYTES is oxygen sensitive. Three different formulations are available.
Aminosyn Formulations Essential Amino Acids (mg/100 mL)
Aminosyn | 3.5% M* | 7% WITH ELECTROLYTES | 8.5% WITH ELECTROLYTES |
Isoleucine | 252 | 510 | 620 |
Leucine | 329 | 660 | 810 |
Lysine (acetate)** | 252 | 510 | 624 |
Methionine | 140 | 280 | 340 |
Phenylalanine | 154 | 310 | 380 |
Threonine | 182 | 370 | 460 |
Tryptophan | 56 | 120 | 150 |
Valine | 280 | 560 | 680 |
*Contains maintenance electrolytes. **Amount cited is for lysine alone and does not include the acetate salt. |
Nonessential Amino Acids (mg/100 mL)
Aminosyn | 3.5% M* | 7% WITH ELECTROLYTES | 8.5% WITH ELECTROLYTES |
Alanine | 448 | 900 | 1100 |
Arginine | 343 | 690 | 850 |
Histidine | 105 | 210 | 260 |
Proline | 300 | 610 | 750 |
Serine | 147 | 300 | 370 |
Tyrosine | 31 | 44 | 44 |
Glycine | 448 | 900 | 1100 |
*Contains maintenance electrolytes. |
Essential Amino Acids
Isoleucine | CH3CH2CH(CH3)CH(NH2)COOH |
Leucine | (CH3)2CHCH2CH(NH2)COOH |
Lysine Acetate | H2N(CH2)4CH(NH2)COOH • CH3COOH |
Methionine | CH3S(CH2)2CH(NH2)COOH |
Phenylalanine |
![]() CH2CH(NH2)COOH |
Threonine | CH3CH(OH)CH(NH2)COOH |
Tryptophan |
CH2CH(NH2)COOH |
Valine | (CH3)2CHCH(NH2)COOH |
Nonessential Amino Acids
Alanine | CH3CH(NH2)COOH |
Arginine | H2NC(NH)NH(CH2)3CH(NH2)COOH |
Glycine | H2NCH2COOH |
Histidine |
CH2CH(NH2)COOH |
Proline |
|
Serine | HOCH2CH(NH2)COOH |
Tyrosine |
|
Electrolytes (mEq/Liter)
Aminosyn | 3.5% M* | 7% WITH ELECTROLYTES | 8.5% WITH ELECTROLYTES |
Sodium (Na+) | 40 | 65 | 65 |
Potassium (K+) | 13 | 65 | 65 |
Magnesium (Mg++) | 3 | 10 | 10 |
Phosphorus (P) | 3.5 (mM)a | 30 (mM)a | 30 (mM)a |
Chloride (Cl–) | 40 | 96b | 98b |
Acetate (C2H3O2–) | 65c | 124d | 142d |
a mM = millimoles; one mM of phosphorus =
31 mg. b Includes chloride from HCl added for processing and pH adjustment. c Includes acetate from acetic acid used in processing and the acetate salts of potassium, magnesium and lysine. d Includes acetate from acetic acid used in processing and from lysine acetate. |
Product Characteristics
Aminosyn | 3.5% M* | 7% WITH ELECTROLYTES | 8.5% WITH ELECTROLYTES |
Protein Equivalent (approx. grams/liter) | 35 | 70 | 85 |
Total Nitrogen (grams/liter) | 5.5 | 11.00 | 13.4 |
Specific Gravity | 1.01 | 1.03 | 1.03 |
Osmolarity (mOsmol/liter) | 421 | 883 | 1040 |
pH | 5.2 (4.5—6.0)e | 5.2 (4.5 — 6.0)f | 5.2 (4.5 — 6.0)f |
e Contains acetic acid for pH adjustment. f Contains hydrochloric acid and acetic acid for pH adjustment. |
Electrolytes (mg/100 mL)
Aminosyn | 3.5% M* |
Sodium Chlorideg | 234 |
Potassium Acetateh | 128 |
86.5% Phosphoric Acidi | 40 |
Magnesium Acetate, anhydrousj | 21 |
*Contains Maintenance Electrolytes |
Aminosyn | 7% WITH ELECTROLYTES | 8.5% WITH ELECTROLYTES |
Sodium Chlorideg | 28 | 28 |
Magnesium Chloride, hexahydratek | 102 | 102 |
Sodium Phosphate, dibasicl | 425 | 425 |
Potassium Chloridem | 487 | 487 |
g Sodium Chloride, USP is chemically designated
NaCl, a white crystalline powder freely soluble in water. h Potassium Acetate, USP is chemically designated CH3COOK, colorless crystals or white crystalline powder very soluble in water. i Phosphoric Acid 86.5%, NF is chemically designated H3PO4, a colorless, syrupy liquid miscible with water. j Magnesium Acetate is chemically designated magnesium acetate, tetrahydrate, Mg(CH3COO)2 • 4H2O, colorless or white crystals very soluble in water. k Magnesium Chloride, USP is chemically designated magnesium chloride, hexahydrate, MgCl2 • 6H2O, deliquescent crystals very soluble in water. l Sodium Phosphate, dibasic, USP is chemically designated Na2HPO4, white granules very soluble in water. m Potassium Chloride, USP is chemically designated KCI, a white granular powder freely soluble in water. |
The formulas for the individual amino acids present in Aminosyn are as follows:
Essential Amino Acids | |
Isoleucine, USP | (C6H13NO2) |
Leucine, USP | (C6H13NO2) |
Lysine Acetate, USP | (C6H14N2O2 • CH3COOH) |
Methionine, USP | (C5H11NO2S) |
Phenylalanine, USP | (C9H11NO2) |
Threonine, USP | (C4H9NO3) |
Tryptophan, USP | (C11H12N2O2) |
Valine, USP | (C5H11NO2) |
Nonessential Amino Acids | |
Alanine, USP | (C3H7NO2) |
Arginine, USP | (C6H14N4O2) |
Histidine, USP | (C6H9N3O2) |
Proline, USP | (C5H9NO2) |
Serine, USP | (C3H7NO3) |
Tyrosine, USP | (C9H11NO3) |
Glycine, USP | (C2H5NO2) |
The flexible plastic container is fabricated from a specially formulated polyvinylchloride. Water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly.
Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials.
Exposure to temperatures above 25°C/77°F during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period.
Related Drugs Index:
- Aminosyn II 8.5%
- Aminosyn Sulfite Free
- Aminosyn HF 8%
- Aminosyn PF 7% Sulfite Free
- Aminosyn HBC 7% Sulfite Free
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