Apresoline

(Generic versions may still be available.)

DRUG DESCRIPTION

Apresoline, hydralazine hydrochloride USP, is an antihypertensive, available as 10-, 25-, 50-, and 100-mg tablets for oral administration. Its chemical name is 1-hydrazinophthalazine monohydrochloride, and its structural formula is:

Hydralazine hydrochloride, USP is a white to off-white, odorless crystalline powder. It is soluble in water, slightly soluble in alcohol, and very slightly soluble in ether. It melts at about 275C, with decomposition, and has a molecular weight of 196.84.

Inactive Ingredients. Acacia, D&C Yellow No. 10 (10-mg tablets), FD&C Blue No. 1 (25-mg and 50-mg tablets), FD&C Yellow No. 5 and FD&C Yellow No. 6 (100-mg tablets), lactose, magnesium stearate, mannitol, polyethylene glycol, sodium starch glycolate, starch, and stearic acid.

What are the possible side effects of hydralazine (Apresoline)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • fast or pounding heartbeats;
  • swelling in your face, stomach, hands, or feet;
  • numbness, burning, pain, or tingly feeling;
  • feeling like you might pass out;
  • confusion, unusual thoughts or behavior;
  • pale skin, easy bruising;
  • painful...

Read All Potential Side Effects and See Pictures of Apresoline

What are the precautions when taking hydralazine (Apresoline)?

Before taking hydralazine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: a certain heart condition (coronary artery disease), a certain heart valve problem (rheumatic heart disease of the mitral valve).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood vessel problems, previous stroke, kidney problems.

This drug may make you dizzy. Do not drive, use machinery, or do any activity...

Read All Potential Precautions of Apresoline


Apresoline Consumer (continued)

SIDE EFFECTS: Headache, pounding/fast heartbeat, loss of appetite, nausea, vomiting, diarrhea, or dizziness may occur as your body adjusts to the medication. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To reduce the risk of dizziness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may infrequently cause nerve problems. Tell your doctor promptly if you experience numbness or tingling. Your doctor may recommend a vitamin B6 supplement (pyridoxine).

Tell your doctor immediately if any of these unlikely but serious side effects occur: severe tiredness, aching/swollen joints, rash on nose and cheeks, swollen glands, change in the amount of urine, bloody/pink urine, signs of infection (such as fever, chills, persistent sore throat), easy bruising/bleeding.

Seek immediate medical attention if this rare but serious side effect occurs: chest/jaw/left arm pain.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking hydralazine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: a certain heart condition (coronary artery disease), a certain heart valve problem (rheumatic heart disease of the mitral valve).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood vessel problems, previous stroke, kidney problems.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Older adults may be more sensitive to the side effects of this medication, especially dizziness.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known whether hydralazine passes into breast milk. However, it is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.


Apresoline Patient Information Including Side Effects

Brand Names: Apresoline

Generic Name: hydralazine (Pronunciation: hye DRAL a zeen)

  • What is hydralazine (Apresoline)?
  • What are the possible side effects of hydralazine (Apresoline)?
  • What is the most important information I should know about hydralazine (Apresoline)?
  • What should I discuss with my healthcare provider before taking hydralazine (Apresoline)?
  • How should I take hydralazine (Apresoline)?
  • What happens if I miss a dose (Apresoline)?
  • What happens if I overdose (Apresoline)?
  • What should I avoid while taking hydralazine (Apresoline)?
  • What other drugs will affect hydralazine (Apresoline)?
  • Where can I get more information?

What is hydralazine (Apresoline)?

Hydralazine is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). This lowers blood pressure and allows blood to flow more easily through your veins and arteries.

Hydralazine is used to treat high blood pressure (hypertension).

Hydralazine may also be used for other purposes not listed in this medication guide.

What are the possible side effects of hydralazine (Apresoline)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • fast or pounding heartbeats;
  • swelling in your face, stomach, hands, or feet;
  • numbness, burning, pain, or tingly feeling;
  • feeling like you might pass out;
  • confusion, unusual thoughts or behavior;
  • pale skin, easy bruising;
  • painful or difficult urination;
  • dark-colored urine;
  • urinating less than usual or not at all; or
  • joint pain or swelling with fever, chest pain, weakness or tired feeling.

Less serious side effects may include:

  • nausea, vomiting, loss of appetite;
  • diarrhea, constipation;
  • headache;
  • dizziness;
  • anxiety;
  • muscle or joint pain;
  • runny or stuffy nose; or
  • mild itching or skin rash.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about hydralazine (Apresoline)?

You should not use this medication if you are allergic to hydralazine, or if you have coronary artery disease, or rheumatic heart disease affecting the mitral valve.

Before taking hydralazine, tell your doctor if you have kidney disease, lupus, angina pectoris (chest pain), or if you have ever had a stroke.

While taking hydralazine, avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Call your doctor at once if you have a serious side effect such as fast or pounding heartbeats, swelling, numbness or tingling, dark-colored urine, joint pain or swelling with fever, chest pain, weakness or tired feeling, and urinating less than usual or not at all.

To be sure this medication is helping your condition and is not causing harmful effects, your blood pressure will need to be checked often. You may also need occasional blood tests. Do not miss any scheduled appointments.

Keep using hydralazine as directed, even if you feel well. High blood pressure often has no symptoms, so you may not know when your blood pressure is high. You may need to use blood pressure medication for the rest of your life.

Related Drug Centers
  • Apresoline


Related Drugs Index: