Anzemet Injection

DRUG DESCRIPTION

ANZEMET (dolasetron mesylate) is an antinauseant and antiemetic agent. Chemically, dolasetron mesylate is (2?,6?,8?,9a?)-octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-lH- indole-3-carboxylate monomethanesulfonate, monohydrate. It is a highly specific and selective serotonin subtype 3 (5-HT3) receptor antagonist both in vitro and in vivo. Dolasetron mesylate has the following structural formula:

Anzemet (dolasetron mesylate)  structural formula illustration

The empirical formula is C19H20N2O3 CH3SO3H H2O, with a molecular weight of 438.50.

Approximately 74% of dolasetron mesylate monohydrate is dolasetron base.

Dolasetron mesylate monohydrate is a white to off-white powder that is freely soluble in water and propylene glycol, slightly soluble in ethanol, and slightly soluble in normal saline.

ANZEMET Injection (dolasetron mesylate injection) is a clear, colorless, nonpyrogenic, sterile solution for intravenous administration. Each milliliter of ANZEMET Injection (dolasetron mesylate injection) contains 20 mg of dolasetron mesylate and 38.2 mg mannitol, USP, with an acetate buffer in water for injection. The pH of the resulting solution is 3.2 to 3.8.

ANZEMET Injection (dolasetron mesylate injection) multidose vials contain a clear, colorless, nonpyrogenic, sterile solution for intravenous administration. Each ANZEMET multidose vial contains 25 mL (500 mg) dolasetron mesylate. Each milliliter contains 20 mg dolasetron mesylate, 29 mg mannitol, USP, and 5 mg phenol, USP, with an acetate buffer in water for injection. The pH of the resulting solution is 3.2 to 3.7.

What are the possible side effects of dolasetron (Anzemet)?

If you experience any of the following uncommon but serious side effects, stop taking dolasetron and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • irregular heartbeats; or
  • muscle cramps or uncontrollable movements.

Other, less serious side effects may be more likely to occur. Continue to take dolasetron and talk to your doctor if you experience

    ...

Read All Potential Side Effects and See Pictures of Anzemet Injection


Anzemet Injection Patient Information Including Side Effects

Brand Names: Anzemet

Generic Name: dolasetron (Pronunciation: doe LAH seh tron)

  • What is dolasetron (Anzemet Injection)?
  • What are the possible side effects of dolasetron (Anzemet Injection)?
  • What is the most important information I should know about dolasetron (Anzemet Injection)?
  • Who should not take dolasetron (Anzemet Injection)?
  • How should I take dolasetron (Anzemet Injection)?
  • What happens if I miss a dose (Anzemet Injection)?
  • What happens if I overdose (Anzemet Injection)?
  • What should I avoid while taking dolasetron (Anzemet Injection)?
  • What other drugs will affect dolasetron (Anzemet Injection)?
  • Where can I get more information?

What is dolasetron (Anzemet Injection)?

Dolasetron blocks the actions of chemicals in the body that may cause nausea and vomiting.

Dolasetron is used to prevent nausea and vomiting associated with cancer chemotherapy or surgery.

Dolasetron may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of dolasetron (Anzemet Injection)?

If you experience any of the following uncommon but serious side effects, stop taking dolasetron and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • irregular heartbeats; or
  • muscle cramps or uncontrollable movements.

Other, less serious side effects may be more likely to occur. Continue to take dolasetron and talk to your doctor if you experience

  • headache;
  • fatigue, drowsiness, or dizziness; or
  • diarrhea.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about dolasetron (Anzemet Injection)?

Do not take dolasetron without first talking to your doctor if you have heart problems or if you take other medicines. Dolasetron can affect the way that your heart beats, which can be dangerous.

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