Altace Capsules

DRUG DESCRIPTION

Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid derivative. It is a white, crystalline substance soluble in polar organic solvents and buffered aqueous solutions. Ramipril melts between 105C and 112C.

The CAS Registry Number is 87333-19-5. Ramipril's chemical name is (2S,3aS,6aS)-1[(S)-N-[(S)-1-Carboxy-3-phenylpropyl] alanyl] octahydrocyclopenta [b]pyrrole-2-carboxylic acid, 1-ethyl ester; its structural formula is:

ALTACE (ramipril) structural formula illustration

Its empiric formula is C23H32N2O5, and its molecular weight is 416.5.

Ramiprilat, the diacid metabolite of ramipril, is a non-sulfhydryl angiotensin converting enzyme inhibitor. Ramipril is converted to ramiprilat by hepatic cleavage of the ester group.

ALTACE (ramipril) is supplied as hard shell capsules for oral administration containing 1.25 mg, 2.5 mg, 5 mg, and 10 mg of ramipril. The inactive ingredients present are pregelatinized starch NF, gelatin, and titanium dioxide. The 1.25 mg capsule shell contains yellow iron oxide, the 2.5 mg capsule shell contains D&C yellow #10 and FD&C red #40, the 5 mg capsule shell contains FD&C blue #1 and FD&C red #40, and the 10 mg capsule shell contains FD&C blue #1.

What are the possible side effects of ramipril (Altace)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • feeling light-headed, fainting;
  • urinating less than usual, or not at all;
  • fever, chills, body aches, flu symptoms;
  • pale skin, easy bruising or bleeding, unusual weakness;
  • pounding or uneven heartbeats;
  • slow heart rate, weak...

Read All Potential Side Effects and See Pictures of Altace Capsules

What are the precautions when taking ramipril capsules (Altace Capsules)?

Before taking ramipril, tell your doctor or pharmacist if you are allergic to it; or to other ACE inhibitors (such as benazepril); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of an allergic reaction which included swelling of the face/lips/tongue/throat (angioedema), blood filtering procedures (such as LDL apheresis, dialysis), high level of potassium in the blood, collagen vascular disease (such as lupus, scleroderma).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are...

Read All Potential Precautions of Altace Capsules


Altace Capsules Consumer (continued)

SIDE EFFECTS: Dizziness, lightheadedness, or tiredness may occur as your body adjusts to the medication. Dry cough may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: fainting, muscle weakness, signs of infection (such as fever, chills, persistent sore throat), change in the amount of urine.

This drug may rarely cause serious (possibly fatal) liver problems. Tell your doctor right away if you notice any of the following rare but serious side effects: yellowing eyes/skin, dark urine, severe stomach/abdominal pain, persistent nausea/vomiting.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking ramipril, tell your doctor or pharmacist if you are allergic to it; or to other ACE inhibitors (such as benazepril); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of an allergic reaction which included swelling of the face/lips/tongue/throat (angioedema), blood filtering procedures (such as LDL apheresis, dialysis), high level of potassium in the blood, collagen vascular disease (such as lupus, scleroderma).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Too much sweating, diarrhea, or vomiting may cause loss of too much body water (dehydration) and increase your risk of lightheadedness. Report prolonged diarrhea or vomiting to your doctor. Be sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This product may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist.

Older adults may be more sensitive to the effects of this product, especially dizziness.

This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details. (See also Warning section.)

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.


Altace Capsules Patient Information Including Side Effects

Brand Names: Altace

Generic Name: ramipril (Pronunciation: RAM i pril)

  • What is ramipril (Altace Capsules)?
  • What are the possible side effects of ramipril (Altace Capsules)?
  • What is the most important information I should know about ramipril (Altace Capsules)?
  • What should I discuss with my healthcare provider before taking ramipril (Altace Capsules)?
  • How should I take ramipril (Altace Capsules)?
  • What happens if I miss a dose (Altace Capsules)?
  • What happens if I overdose (Altace Capsules)?
  • What should I avoid while taking ramipril (Altace Capsules)?
  • What other drugs will affect ramipril (Altace Capsules)?
  • Where can I get more information?

What is ramipril (Altace Capsules)?

Ramipril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme.

Ramipril is used to treat high blood pressure (hypertension), heart failure, and to improve survival after a heart attack.

Ramipril may also be used for other purposes not listed in this medication guide.

What are the possible side effects of ramipril (Altace Capsules)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • feeling light-headed, fainting;
  • urinating less than usual, or not at all;
  • fever, chills, body aches, flu symptoms;
  • pale skin, easy bruising or bleeding, unusual weakness;
  • pounding or uneven heartbeats;
  • slow heart rate, weak pulse, muscle weakness, tingly feeling;
  • jaundice (yellowing of the skin or eyes);
  • chest pain; or
  • swelling, rapid weight gain.

Less serious side effects may include:

  • cough;
  • dizziness, drowsiness, headache;
  • sleep problems (insomnia);
  • decreased sex drive, impotence, or difficulty having an orgasm;
  • nausea, vomiting; or
  • mild skin itching or rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about ramipril (Altace Capsules)?

Do not use this medication without telling your doctor if you are pregnant or planning a pregnancy. Ramipril could cause birth defects in the baby if you take the medication during pregnancy. Use an effective form of birth control. Stop using this medication and tell your doctor right away if you become pregnant during treatment.

Avoid drinking alcohol. It can further lower your blood pressure and may increase some of the side effects of ramipril.

Do not use salt substitutes or potassium supplements while taking ramipril, unless your doctor has told you to.

Vomiting, diarrhea, or heavy sweating can cause you to become dehydrated. This can lead to very low blood pressure, electrolyte disorders, or kidney failure while you are taking ramipril. Drink plenty of water each day while you are taking this medication.

Related Drug Centers
  • Altace Capsules
  • Altace


Related Drugs Index: