Ancobon

DRUG DESCRIPTION

Ancobon (flucytosine), an antifungal agent, is available as 250mg and 500mg capsules for oral administration. Each capsule also contains corn starch, lactose and talc. Gelatin capsule shells contain parabens (butyl, methyl, propyl) and sodium propionate, with the following dye systems: 250-mg capsules — black iron oxide, FD&C Blue No. 1, FD&C Yellow No. 6, D&C Yellow No. 10 and titanium dioxide; 500mg capsules — black iron oxide and titanium dioxide. Chemically, flucytosine is 5-fluorocytosine, a fluorinated pyrimidine which is related to fluorouracil and floxuridine. It is a white to off-white crystalline powder with a molecular weight of 129.09 and the following structural formula:

ANCOBON® (flucytosine)  Structural Formula Illustration

What are the possible side effects of flucytosine (Ancobon)?

If you experience any of the following serious side effects, stop taking flucytosine and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
  • chest pain;
  • yellowing of the skin or eyes;
  • little or no urine;
  • confusion or hallucinations;
  • numbness or tingling; or
  • hearing loss.

Other, less serious side effects may be more...

Read All Potential Side Effects and See Pictures of Ancobon »

What are the precautions when taking flucytosine (Ancobon)?

Before taking flucytosine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, liver problems, decreased bone marrow function, a low number of blood cells (red or white blood cells, platelets), radiation treatment, mineral imbalance (such as low level of potassium in the blood).

Wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been...

Read All Potential Precautions of Ancobon »


Ancobon Consumer (continued)

SIDE EFFECTS: Nausea, vomiting, or diarrhea may occur. See the How to Use section about how to reduce stomach upset. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: change in the amount of urine, signs of liver problems (such as persistent nausea/vomiting, stomach/abdominal pain, dark urine, yellowing eyes/skin), signs of anemia (such as unusual tiredness, fast breathing, pale skin, fast heartbeat), signs of infection (such as fever, chills, cough, persistent sore throat), signs of bleeding (such as easy bruising/bleeding, nose bleeds, bleeding gums, bloody/black/tarry stools, vomit that looks like coffee grounds), muscle weakness/cramping.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking flucytosine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, liver problems, decreased bone marrow function, a low number of blood cells (red or white blood cells, platelets), radiation treatment, mineral imbalance (such as low level of potassium in the blood).

Wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, older adults may be more sensitive to the side effects of this drug.

During pregnancy, this medication should be used only when clearly needed. This medication is not recommended for use during the first 3 months of pregnancy. It may harm an unborn baby. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. It may have undesirable effects on a nursing infant. Breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.


Ancobon Patient Information Including Side Effects

Brand Names: Ancobon

Generic Name: flucytosine (Pronunciation: floo SYE toe seen)

  • What is flucytosine (Ancobon)?
  • What are the possible side effects of flucytosine (Ancobon)?
  • What is the most important information I should know about flucytosine (Ancobon)?
  • What should I discuss with my healthcare provider before taking flucytosine (Ancobon)?
  • How should I take flucytosine (Ancobon)?
  • What happens if I miss a dose (Ancobon)?
  • What happens if I overdose (Ancobon)?
  • What should I avoid while taking flucytosine (Ancobon)?
  • What other drugs will affect flucytosine (Ancobon)?
  • Where can I get more information?

What is flucytosine (Ancobon)?

Flucytosine is an antifungal medication. It is like an antibiotic but is used to treat fungal infections.

Flucytosine is used to treat serious fungal infections of the blood, lungs, heart, central nervous system, and urinary tract.

Flucytosine may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of flucytosine (Ancobon)?

If you experience any of the following serious side effects, stop taking flucytosine and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
  • chest pain;
  • yellowing of the skin or eyes;
  • little or no urine;
  • confusion or hallucinations;
  • numbness or tingling; or
  • hearing loss.

Other, less serious side effects may be more likely to occur. Continue to take flucytosine and talk to your doctor if you experience

  • nausea, vomiting, decreased appetite, or diarrhea;
  • a dry mouth;
  • headache;
  • sedation; or
  • weakness or poor coordination.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about flucytosine (Ancobon)?

Take all of the flucytosine that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated.

Flucytosine may cause nausea and vomiting. You can reduce this side effect by taking the capsules a few at a time over a 15-minute period.

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