Kineret

DRUG DESCRIPTION

Kineret (anakinra) is a recombinant, nonglycosylated form of the human interleukin-1 receptor antagonist (IL-1Ra). Kineret differs from native human IL-1Ra in that it has the addition of a single methionine residue at its amino terminus. Kineret consists of 153 amino acids and has a molecular weight of 17.3 kilodaltons. It is produced by recombinant DNA technology using an E coli bacterial expression system.

Kineret is supplied in single use prefilled glass syringes with 27 gauge needles as a sterile, clear, colorless-to-white, preservative free solution for daily subcutaneous (SC) administration. The solution may contain trace amounts of small, translucent-to-white amorphous proteinaceous particles. Each prefilled glass syringe contains: 0.67 mL (100 mg) of anakinra in a solution (pH 6.5) containing disodium EDTA (0.12 mg), sodium chloride (5.48 mg), sodium citrate (1.29 mg), and polysorbate 80 (0.70 mg) in Water for Injection, USP.

What are the possible side effects of anakinra (Kineret)?

If you experience an allergic reaction (difficulty breathing; closing of the throat; swelling of your lips, tongue, or face; or hives), stop using anakinra, and seek emergency medical attention.

In rare cases, people receiving anakinra have developed serious infections. Notify your doctor immediately if you develop a fever, flu-like symptoms, or any other sign of infection.

Other less serious side effects may be more likely to occur. Continue to use anakinra and notify your doctor if you experience

  • nausea or...

Read All Potential Side Effects and See Pictures of Kineret

What are the precautions when taking anakinra (Kineret)?

Before using anakinra, tell your doctor or pharmacist if you are allergic to it; or to proteins made from a certain bacteria (E. coli); or to latex; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: recent/current infection, immune system problems (such as HIV disease), kidney disease, asthma.

Anakinra can make you more likely to get infections or may worsen any current infections. Therefore, wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles,...

Read All Potential Precautions of Kineret


Kineret Consumer (continued)

SIDE EFFECTS: Redness, bruising, swelling, and pain at the injection site may occur. These skin reactions are usually mild and may last 2 to 4 weeks. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Anakinra has caused very serious infections (such as skin/bone/joint infections, pneumonia). Tell your doctor immediately if you develop signs of an infection, including: fever/chills, persistent sore throat, cough with mucus, spreading redness/swelling/tenderness of the skin, bone pain.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using anakinra, tell your doctor or pharmacist if you are allergic to it; or to proteins made from a certain bacteria (E. coli); or to latex; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: recent/current infection, immune system problems (such as HIV disease), kidney disease, asthma.

Anakinra can make you more likely to get infections or may worsen any current infections. Therefore, wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

Older adults may be at greater risk for infections while using this drug.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.


Kineret Patient Information Including Side Effects

Brand Names: Kineret

Generic Name: anakinra (injectable) (Pronunciation: an na KIN rah)

  • What is anakinra (Kineret)?
  • What are the possible side effects of anakinra (Kineret)?
  • What is the most important information I should know about anakinra (Kineret)?
  • What should I discuss with my healthcare provider before using anakinra (Kineret)?
  • How should I use anakinra (Kineret)?
  • What happens if I miss a dose (Kineret)?
  • What happens if I overdose (Kineret)?
  • What should I avoid while using anakinra (Kineret)?
  • What other drugs will affect anakinra (Kineret)?
  • Where can I get more information?

What is anakinra (Kineret)?

Anakinra reduces the actions of chemicals in the body that are involved in inflammatory and immune responses.

Anakinra is used to treat the symptoms of moderate to severe rheumatoid arthritis in patients who have had an inadequate response to one or more antirheumatic drugs. Anakinra may be used in combination with other antirheumatic medications.

Anakinra may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of anakinra (Kineret)?

If you experience an allergic reaction (difficulty breathing; closing of the throat; swelling of your lips, tongue, or face; or hives), stop using anakinra, and seek emergency medical attention.

In rare cases, people receiving anakinra have developed serious infections. Notify your doctor immediately if you develop a fever, flu-like symptoms, or any other sign of infection.

Other less serious side effects may be more likely to occur. Continue to use anakinra and notify your doctor if you experience

  • nausea or diarrhea;
  • a headache;
  • sinus irritation or infection; or
  • redness, bruising, pain, or swelling at the injection site.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about anakinra (Kineret)?

In rare cases, people receiving anakinra have developed serious infections. Notify your doctor immediately if you develop a fever, flu-like symptoms, or any other sign of infection. Treatment with anakinra should not be started in patients with active infections or those taking other medicines that may suppress the immune system. The use of anakinra in combination with etanercept (Enbrel), infliximab (Remicade), adalimumab (Humira), or other medicines used to treat rheumatoid arthritis, may also increase the risk of a serious infection.

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