Biltricide

DRUG DESCRIPTION

BILTRICIDE® (praziquantel) is a trematodicide provided in tablet form for the oral treatment of schistosome infections and infections due to liver fluke.

BILTRICIDE (praziquantel) is 2-(cyclohexylcarbonyl)-1,2,3,6,7, 11b-hexahydro-4H-pyrazino [2, 1-a] isoquinolin-4-one with the molecular formula; C19H24N2O2. The structural formula is as follows:

BILTRICIDE® (praziquantel)  Structural Formula Illustration

Praziquantel is a white to nearly white crystalline powder of bitter taste. The compound is stable under normal conditions and melts at 136-140°C with decomposition. The active substance is hygroscopic. Praziquantel is easily soluble in chloroform and dimethylsulfoxide, soluble in ethanol and very slightly soluble in water.

BILTRICIDE tablets contain 600 mg of praziquantel. Inactive ingredients: corn starch, magnesium stearate, microcrystalline cellulose, povidone, sodium lauryl sulfate, polyethylene glycol, titanium dioxide and hypromellose.

What are the possible side effects of praziquantel (Biltricide)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:

  • tired feeling;
  • headache, dizziness;
  • nausea, upset stomach;
  • mild fever; or
  • mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at...

Read All Potential Side Effects and See Pictures of Biltricide »

What are the precautions when taking praziquantel (Biltricide)?

Before taking praziquantel, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: parasitic eye infection (ocular cysticercosis).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease/enlarged spleen, heart disease/irregular heart rhythm, parasitic brain infection (cerebral cysticercosis), seizures.

This drug may make you dizzy or drowsy during treatment until the day after...

Read All Potential Precautions of Biltricide »


Biltricide Consumer (continued)

SIDE EFFECTS: Headache, dizziness, stomach pain, nausea, tiredness, weakness, joint/muscle pain, loss of appetite, vomiting, and sweating may occur. These side effects are usually mild and temporary and may be symptoms of your parasite infection and/or the dying parasites. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these rare but very serious side effects occur: bloody diarrhea, fever, irregular/slow heartbeat, seizures.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking praziquantel, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: parasitic eye infection (ocular cysticercosis).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease/enlarged spleen, heart disease/irregular heart rhythm, parasitic brain infection (cerebral cysticercosis), seizures.

This drug may make you dizzy or drowsy during treatment until the day after treatment. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This drug passes into breast milk. Breast-feeding while using this drug is not recommended. Nursing mothers should temporarily stop breast-feeding on the day of treatment and for 72 hours after taking the last dose. Pump and discard breast milk during this time.


Biltricide Patient Information Including Side Effects

Brand Names: Biltricide

Generic Name: praziquantel (Pronunciation: PRAZ i KWON tel)

  • What is praziquantel (Biltricide)?
  • What are the possible side effects of praziquantel (Biltricide)?
  • What is the most important information I should know about praziquantel (Biltricide)?
  • What should I discuss with my healthcare provider before taking praziquantel (Biltricide)?
  • How should I take praziquantel (Biltricide)?
  • What happens if I miss a dose (Biltricide)?
  • What happens if I overdose (Biltricide)?
  • What should I avoid while taking praziquantel (Biltricide)?
  • What other drugs will affect praziquantel (Biltricide)?
  • Where can I get more information?

What is praziquantel (Biltricide)?

Praziquantel is an anthelmintic (an-thel-MIN-tik) or anti-worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in your body.

Praziquantel is used to treat infections caused by Schistosoma worms, which enter the body through skin that has come into contact with contaminated water. Schistosoma worms are found in Africa, South America, Middle Eastern countries, the Carribean, and parts of Asia.

Praziquantel is also used to treat infection with liver flukes, caused by a type of worm found in East Asia. This worm enters the body while eating contaminated fish.

Praziquantel should not be used to treat parasitic infections in the eye.

Praziquantel may also be used for other purposes not listed in this medication guide.

What are the possible side effects of praziquantel (Biltricide)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:

  • tired feeling;
  • headache, dizziness;
  • nausea, upset stomach;
  • mild fever; or
  • mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about praziquantel (Biltricide)?

Do not use this medication if you are allergic to praziquantel, or if you are also taking rifampin (Rifadin, Rifater, Rifamate).

Before taking praziquantel, tell your doctor if you have kidney disease, heart disease, or liver disease.

Do not give this medication to a child younger than 4 years old.

Praziquantel can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Praziquantel should be taken with a meal.

Do not crush or chew the praziquantel tablet. Swallow the pill whole.

Take this medication with a full glass (8 ounces) of water.

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