Benzamycin

DRUG DESCRIPTION

Benzamycin® Pak contains erythromycin [(3R*, 4S*, 5S*, 6R*, 7R*, 9R*, 11R*, 12R*, 13S*, 14R*)-4-[(2,6- dideoxy-3-C-methyl-3-O-methyl-a- L-ribo-hexopyranosyl)-oxy]-14- ethyl-7,12,13-trihydroxy- 3,5,7,9,11,13-hexa-methyl-6-[ [3,4,6-trideoxy-3-(dimethylamino)-b-D- xylo-hexopyranosyl] oxy]oxacyclotetradecane-2,10- dione]. Erythromycin is a macrolide antibiotic produced from a strain of Saccharopolyspora erythraea (formerly Streptomyces erythreus). It is a base and readily forms salts with acids. Chemically, erythromycin is (C37H67NO13).  It has the following structural formula:

Erythromycin has the molecular weight of 733.94. It is a white crystalline powder and has a solubility of approximately 1 mg/mL in water and is soluble in alcohol at 25°C. Benzamycin (erythromycin) ® Pak also contains benzoyl peroxide for topical use. Benzoyl peroxide is an oxidizing agent demonstrating antibacterial activity. Chemically, benzoyl peroxide is (C14H10O4).  It has the following structural formula:

Benzoyl peroxide has the molecular weight of 242.23. It is a white granular powder and is sparingly soluble in water and alcohol and soluble in acetone, chloroform and ether. Each gram of product, as dispensed, contains 30 mg of erythromycin and 50 mg of benzoyl peroxide in a base of SD Alcohol 40B, purified water, hydroxypropyl cellulose, carbomer 934, sodium hydroxide, dioctyl sodium sulfosuccinate 75%. Each Benzamycin (erythromycin) ® Pak contains 0.8 grams of product.

What are the possible side effects of benzoyl peroxide and erythromycin topical (Benzamycin)?

Serious side effects are not likely to occur. Stop using benzoyl peroxide and erythromycin topical and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of the throat; swelling of the lips, face, or tongue; or hives).

You may experience some skin burning, stinging, tingling, itching, redness, dryness, peeling, or irritation while using benzoyl peroxide topical. If these side effects are excessive, apply benzoyl peroxide and erythromycin topical less...

Read All Potential Side Effects and See Pictures of Benzamycin »

What are the precautions when taking erythromycin (Benzamycin)?

Before using this product, tell your doctor or pharmacist if you are allergic to erythromycin or benzoyl peroxide; or to other macrolide antibiotics (such as azithromycin, clarithromycin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear a hat or other protective clothing when outdoors.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription...

Read All Potential Precautions of Benzamycin »


Benzamycin Consumer (continued)

SIDE EFFECTS: Mild dryness and mild peeling of the top layer of skin is expected. Skin irritation, itching, burning, or redness may occur, especially at the start of treatment as your body adjusts to the medication. Eye irritation and skin discoloration may also occur. If any of these effects persist or worsen, stop using this product and tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Rarely, use of this medication for prolonged or repeated periods may result in other types of skin infections (such as fungal infections). Contact your doctor if you notice any unusual skin symptoms or if your condition does not improve.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using this product, tell your doctor or pharmacist if you are allergic to erythromycin or benzoyl peroxide; or to other macrolide antibiotics (such as azithromycin, clarithromycin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear a hat or other protective clothing when outdoors.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.


Benzamycin Patient Information Including Side Effects

Brand Names: Benzamycin

Generic Name: benzoyl peroxide and erythromycin topical (Pronunciation: BEN zoe ill per OX ide and er ith roe MYE sin)

  • What is benzoyl peroxide and erythromycin topical (Benzamycin)?
  • What are the possible side effects of benzoyl peroxide and erythromycin topical (Benzamycin)?
  • What is the most important information I should know about benzoyl peroxide and erythromycin topical (Benzamycin)?
  • What should I discuss with my healthcare provider before using benzoyl peroxide and erythromycin topical (Benzamycin)?
  • How should I use benzoyl peroxide and erythromycin topical (Benzamycin)?
  • What happens if I miss a dose (Benzamycin)?
  • What happens if I overdose (Benzamycin)?
  • What should I avoid while taking benzoyl peroxide and erythromycin topical (Benzamycin)?
  • What other drugs will affect benzoyl peroxide and erythromycin topical (Benzamycin)?
  • Where can I get more information?

What is benzoyl peroxide and erythromycin topical (Benzamycin)?

Benzoyl peroxide has an antibacterial effect. It also has a mild drying effect that allows excess oils and dirt to be easily washed away.

Erythromycin is an antibiotic. Erythromycin topical prevents bacteria from growing on the skin.

Together, benzoyl peroxide and erythromycin are used to treat acne.

Benzoyl peroxide and erythromycin topical may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of benzoyl peroxide and erythromycin topical (Benzamycin)?

Serious side effects are not likely to occur. Stop using benzoyl peroxide and erythromycin topical and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of the throat; swelling of the lips, face, or tongue; or hives).

You may experience some skin burning, stinging, tingling, itching, redness, dryness, peeling, or irritation while using benzoyl peroxide topical. If these side effects are excessive, apply benzoyl peroxide and erythromycin topical less often.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about benzoyl peroxide and erythromycin topical (Benzamycin)?

Do not use benzoyl peroxide and erythromycin topical on sunburned, windburned, dry, chapped, or irritated skin or on open wounds.

Avoid abrasive, harsh, or drying soaps and cleansers while using benzoyl peroxide and erythromycin topical.

Avoid contact with clothing and hair. Benzoyl peroxide may cause bleaching.

Avoid combining PABA-containing sunscreens and benzoyl peroxide. Temporary skin discoloration may occur if they are used together.

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