Belladonna and Opium

DRUG DESCRIPTION

Each belladonna and opium suppository contains (in a water-soluble base consisting of Polyethylene Glycol 400, 1450, 8000 and Polysorbate 60):

Belladonna (16.2 mg) and Opium (30 mg): Powdered opium 30 mg (Warning: May be habit forming.) and powdered belladonna extract 16.2 mg.

Belladonna (16.2 mg) and Opium (60 mg): Powdered opium 60 mg (Warning: May be habit forming.) and powdered belladonna extract 16.2 mg.

This drug falls into the pharmacological/ therapeutic class of narcotic analgesic/ antispasmotic agents.

The pharmacologically active principles present in the belladonna extract component of belladonna and opium suppositories are:

Established Name: Atropine
Chemical Name: dl Tropyl Tropate
Chemical Structure:


and
Established Name: Scopolamine
Chemical Name: dl Scopolamine
Chemical Structure:

Opium contains more than twenty alkaloids, the principle ones being morphine (10%), narcotine (6%), papaverine (1%) and codeine (0.5%). The major pharmacologically active principle of the powdered opium component of belladonna and opium suppositories, however, is:

Name: Morphine
Chemical Name: 7,8-Didehydro-4,5-epoxy-17- Methyl-morphinan-3,6-diol
Chemical Structure:

What are the possible side effects of belladonna and opium (B & O Supprettes 15-A, B & O Supprettes 16-A)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • painful or difficult urination;
  • urinating less than usual or not at all;
  • fast heart rate;
  • weak, shallow breathing;
  • extreme weakness, feeling like you might pass out;
  • headache, confusion; or
  • ...

Read All Potential Side Effects and See Pictures of Belladonna and Opium

What are the precautions when taking belladonna and opium (Belladonna and Opium)?

Before using this product, tell your doctor or pharmacist if you are allergic to belladonna or opium; or to narcotic pain medications (such as morphine, codeine); or to atropine or scopolamine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: a certain muscle/nerve disease (myasthenia gravis), certain stomach/bowel diseases (paralytic ileus, blockage, infectious diarrhea), glaucoma (narrow-angle).

Before using this medication, tell your doctor or pharmacist your medical history, especially of:...

Read All Potential Precautions of Belladonna and Opium


Belladonna and Opium Consumer (continued)

SIDE EFFECTS: Nausea, vomiting, constipation, blurred vision, increased eye discomfort in bright light, lightheadedness, dizziness, drowsiness, increased/decreased sweating, or dry mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.

To prevent constipation, maintain a diet adequate in fiber, drink plenty of water, and exercise. Consult your pharmacist for help in selecting a laxative (such as a stimulant type with stool softener).

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes (such as agitation, hallucinations, confusion), difficulty urinating, fainting, slow/fast heartbeat, eye pain, vision changes.

Tell your doctor immediately if any of these rare but very serious side effects occur: severe stomach/abdominal pain, change in the amount of urine, seizures, slow/shallow breathing.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using this product, tell your doctor or pharmacist if you are allergic to belladonna or opium; or to narcotic pain medications (such as morphine, codeine); or to atropine or scopolamine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: a certain muscle/nerve disease (myasthenia gravis), certain stomach/bowel diseases (paralytic ileus, blockage, infectious diarrhea), glaucoma (narrow-angle).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, lung diseases (such as asthma, chronic obstructive pulmonary disease-COPD), breathing problems (such as slow/shallow breathing, sleep apnea), a certain spinal problem (kyphoscoliosis), difficulty urinating (for example, due to enlarged prostate or narrowed urethra), personal or family history of regular use/abuse of drugs/alcohol, heart problems (such as irregular heartbeat, heart failure, coronary artery disease), high blood pressure, brain disorders/injuries (such as seizures, head injury, tumor, increased intracranial pressure), thyroid disease, gallbladder disease, disease of the pancreas (such as pancreatitis), adrenal gland problems (such as Addison's disease), mental/mood disorders (such as toxic psychosis), stomach/intestinal disorders (such as colitis, ulcer), glaucoma (open-angle), heartburn.

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Avoid alcoholic beverages.

To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Before having surgery, tell your doctor or dentist that you are using this medication.

This medication can make you more likely to get heat stroke, a very serious condition. Avoid activities that might cause you to overheat (such as doing strenuous work/exercise in hot weather, using hot tubs).

Older adults may be more sensitive to the effects of this drug, especially slow/shallow breathing and drowsiness.

During pregnancy, this medication should be used only when clearly needed. Using it for long periods or in high doses near the expected delivery date is not recommended because of possible harm to the unborn baby. Discuss the risks and benefits with your doctor. Infants born to mothers who have used this medication for a long time may have withdrawal symptoms such as irritability, abnormal/persistent crying, vomiting, or diarrhea. Tell your doctor immediately if you notice any of these symptoms in your newborn.

It is unknown if belladonna passes into breast milk. Opium passes into breast milk, and the effect on a nursing infant is not known. Discuss the risks and benefits with your doctor before breast-feeding.


Belladonna and Opium Patient Information Including Side Effects

Brand Names: B & O Supprettes 15-A, B & O Supprettes 16-A

Generic Name: belladonna and opium (rectal) (Pronunciation: BEL a DON a and OH pee um)

  • What is belladonna and opium (Belladonna and Opium)?
  • What are the possible side effects of belladonna and opium (Belladonna and Opium)?
  • What is the most important information I should know about belladonna and opium (Belladonna and Opium)?
  • What should I discuss with my health care provider before using belladonna and opium rectal (Belladonna and Opium)?
  • How should I use belladonna and opium rectal (Belladonna and Opium)?
  • What happens if I miss a dose (Belladonna and Opium)?
  • What happens if I overdose (Belladonna and Opium)?
  • What should I avoid while using belladonna and opium (Belladonna and Opium)?
  • What other drugs will affect belladonna and opium (Belladonna and Opium)?
  • Where can I get more information?

What is belladonna and opium (Belladonna and Opium)?

Belladonna is a natural substance made from a toxic plant. The medicinal form of belladonna has many effects in the body, such as decreasing muscle activity.

Opium is also a natural substance made from the seeds of a plant. The medicinal form of opium is a narcotic pain reliever.

The combination of belladonna and opium is used to treat moderate to severe pain caused by muscle spasms in the tubes that connect the kidneys to the bladder.

Belladonna and opium may also be used for other purposes not listed in this medication guide.

What are the possible side effects of belladonna and opium (Belladonna and Opium)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • painful or difficult urination;
  • urinating less than usual or not at all;
  • fast heart rate;
  • weak, shallow breathing;
  • extreme weakness, feeling like you might pass out;
  • headache, confusion; or
  • severe constipation and stomach pain.

Less serious side effects may include:

  • drowsiness, dizziness;
  • blurred vision;
  • nausea, vomiting, constipation;
  • dry mouth, dry eyes;
  • decreased sense of taste; or
  • impotence, loss of interest in sex, or trouble having an orgasm.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about belladonna and opium (Belladonna and Opium)?

Do not take belladonna and opium rectal by mouth. It is for use only in your rectum.

Do not use belladonna and opium if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.

Do not use belladonna and opium if you are also using furazolidone (Furoxone), linezolid (Zyvox), moclobemide, pramlintide (Symlin), procarbazine (Matulane), naltrexone (ReVia), or potassium supplement tablets or capsules.

You should not use belladonna and opium if you have glaucoma, urination problems, a blockage in your stomach or intestines, a head injury, seizures, diarrhea caused by infection, severe liver or kidney disease, severe bleeding, myasthenia gravis, asthma, or if you are intoxicated or debilitated.

Before using this medication, tell your doctor if you have liver or kidney disease, heart disease, high or low blood pressure, a stomach or intestinal disorder, breathing problems, mental illness, spinal curvature, gallbladder disease, Addison's disease, underactive thyroid, drug or alcohol addiction, or if you are allergic to any narcotic medications.

Opium may be habit-forming and should be used only by the person it was prescribed for. Belladonna and opium rectal suppositories should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

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