Sensorcaine

DRUG DESCRIPTION

Sensorcaine (bupivacaine hci injections) (bupivacaine HCl) injections are sterile isotonic solutions that contain a local anesthetic agent with and without epinephrine (as bitartrate) 1:200,000 and are administered parenterally by injection. See INDICATIONS AND USAGE for specific uses. Solutions of bupivacaine HCl may be autoclaved if they do not contain epinephrine.

Sensorcaine (bupivacaine hci injections) injections contain bupivacaine HCl which is chemically designated as 2-piperidinecarboxamide, 1-butyl-N-(2,6- dimethylphenyl)-, monohydrochloride, monohydrate and has the following structure:

Bupivacaine HCl Structural Formula Illustration

Epinephrine is (-)-3,4-Dihydroxy-? [(methylamino)methyl] benzyl alcohol. It has the following structural formula:

The pKa of bupivacaine (8.1) is similar to that of lidocaine (7.86). However, bupivacaine possesses a greater degree of lipid solubility and is protein bound to a greater extent than lidocaine.

Bupivacaine is related chemically and pharmacologically to the aminoacyl local anesthetics. It is a homologue of mepivacaine and is chemically related to lidocaine. All three of these anesthetics contain an amide linkage between the aromatic nucleus and the amino or piperidine group. They differ in this respect from the procaine-type local anesthetics, which have an ester linkage.

Dosage forms listed as Sensorcaine (bupivacaine hci injections) -MPF indicates single dose solutions that are Methyl Paraben Free (MPF).

Sensorcaine (bupivacaine hci injections) -MPF is a sterile isotonic solution containing sodium chloride. Sensorcaine (bupivacaine hci injections) in multiple dose vials, each mL also contains 1 mg methylparaben as antiseptic preservative. The pH of these solutions is adjusted to between 4.0 and 6.5 with sodium hydroxide and/ or hydrochloric acid.

Sensorcaine (bupivacaine hci injections) -MPF with Epinephrine 1:200,000 (as bitartrate) is a sterile isotonic solution containing sodium chloride. Each mL contains bupivacaine hydrochloride and 0.005 mg epinephrine, with 0.5 mg sodium metabisulfite as an antioxidant and 0.2 mg citric acid (anhydrous) as stabilizer. Sensorcaine (bupivacaine hci injections) with Epinephrine 1:200,000 (as bitartrate) in multiple dose vials, each mL also contains 1 mg methylparaben as antiseptic preservative. The pH of these solutions is adjusted to between 3.3 to 5.5 with sodium hydroxide and/ or hydrochloric acid. Filled under nitrogen.

Note: The user should have an appreciation and awareness of the formulations and their intended uses. (See DOSAGE AND ADMINISTRATION.)

What are the possible side effects of bupivacaine (Marcaine HCl, Marcaine Spinal, Sensorcaine, Sensorcaine-MPF)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects:

  • weak or shallow breathing;
  • fast heart rate, gasping, feeling unusually hot;
  • slow heart rate, weak pulse;
  • feeling restless or anxious, ringing in the ears, metallic taste, speech problems, numbness or...

Read All Potential Side Effects and See Pictures of Sensorcaine


Sensorcaine Patient Information Including Side Effects

Brand Names: Marcaine HCl, Marcaine Spinal, Sensorcaine, Sensorcaine-MPF

Generic Name: bupivacaine (Pronunciation: bue PIV a kane)

  • What is bupivacaine (Sensorcaine)?
  • What are the possible side effects of bupivacaine (Sensorcaine)?
  • What is the most important information I should know about bupivacaine (Sensorcaine)?
  • What should I discuss with my health care provider before receiving bupivacaine (Sensorcaine)?
  • How is bupivacaine given (Sensorcaine)?
  • What happens if I miss a dose (Sensorcaine)?
  • What happens if I overdose (Sensorcaine)?
  • What should I avoid after receiving bupivacaine (Sensorcaine)?
  • What other drugs will affect bupivacaine (Sensorcaine)?
  • Where can I get more information?

What is bupivacaine (Sensorcaine)?

Bupivacaine is an anesthetic (numbing medicine) that blocks the nerve impulses that send pain signals to your brain.

Bupivacaine is used as a local (in only one area) anesthetic for a spinal block.

Bupivacaine may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of bupivacaine (Sensorcaine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects:

  • weak or shallow breathing;
  • fast heart rate, gasping, feeling unusually hot;
  • slow heart rate, weak pulse;
  • feeling restless or anxious, ringing in the ears, metallic taste, speech problems, numbness or tingling around your mouth, tremors, feeling light-headed, or fainting; or
  • problems with urination.

Less serious side effects include:

  • nausea, vomiting;
  • headache, back pain;
  • dizziness;
  • or problems with sexual function.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about bupivacaine (Sensorcaine)?

You should not receive bupivacaine if you have ever had an allergic reaction to any type of numbing medicine.

Before receiving this medication, tell your doctor if you have liver disease, a bleeding or blood clotting disorder, syphilis, polio, a brain or spinal cord tumor, chronic back pain, a headache, low or high blood pressure, a curved spine, or arthritis.

This medication can cause numbness over a large portion of your body. Take care to avoid injury before the feeling has returned completely.

Spinal numbing medications can have long-lasting or permanent effects on certain body processes such as sexual function, bowel or bladder control, and movement or feeling in your legs or feet. Talk with your doctor about your specific risk of nerve damage from bupivacaine.

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  • Sensorcaine
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