Cancidas

DRUG DESCRIPTION

CANCIDAS (caspofungin acetate) is a sterile, lyophilized product for intravenous (IV) infusion that contains a semisynthetic lipopeptide (echinocandin) compound synthesized from a fermentation product of Glarea lozoyensis.

CANCIDAS (caspofungin acetate) is an echinocandin that inhibits the synthesis of ? (1,3)-D-glucan, an integral component of the fungal cell wall.

CANCIDAS (caspofungin acetate) is 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-(10,12-dimethyl-1oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine] pneumocandin B0 diacetate (salt). CANCIDAS (caspofungin acetate) 50 mg also contains: 39 mg sucrose, 26 mg mannitol, glacial acetic acid, and sodium hydroxide. CANCIDAS (caspofungin acetate) 70 mg also contains 54 mg sucrose, 36 mg mannitol, glacial acetic acid, and sodium hydroxide. Caspofungin acetate is a hygroscopic, white to off-white powder. It is freely soluble in water and methanol, and slightly soluble in ethanol. The pH of a saturated aqueous solution of caspofungin acetate is approximately 6.6. The empirical formula is C52H88N10O152C2H4O2 and the formula weight is 1213.42. The structural formula is:

CANCIDAS (caspofungin acetate) Structural Formula Illustration

What are the possible side effects of caspofungin (Cancidas)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor right away if you have any of these serious side effects:

  • pain, swelling, or vein irritation where the medicine is injected;
  • fever, chills, body aches, flu symptoms;
  • swelling in your hands or feet;
  • weakness, muscle cramps, pounding or uneven heart beats; or
  • nausea, stomach pain, loss of appetite,...

Read All Potential Side Effects and See Pictures of Cancidas

What are the precautions when taking caspofungin acetate (Cancidas)?

Before using caspofungin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before...

Read All Potential Precautions of Cancidas


Cancidas Consumer (continued)

SIDE EFFECTS: Nausea, diarrhea, fever, red/warm skin (flushing), headache, or irritation at the injection site may occur. If any of these effects persist or worsen, tell your doctor.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: persistent nausea/vomiting, severe stomach/abdominal pain, dark urine, yellowing eyes/skin.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using caspofungin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.


Cancidas Patient Information Including Side Effects

Brand Names: Cancidas

Generic Name: caspofungin (Pronunciation: KAS poe FUN jin)

  • What is caspofungin (Cancidas)?
  • What are the possible side effects of caspofungin (Cancidas)?
  • What is the most important information I should know about caspofungin (Cancidas)?
  • What should I discuss with my health care provider before receiving caspofungin (Cancidas)?
  • How is caspofungin given (Cancidas)?
  • What happens if I miss a dose (Cancidas)?
  • What happens if I overdose (Cancidas)?
  • What should I avoid while receiving caspofungin (Cancidas)?
  • What other drugs will affect caspofungin (Cancidas)?
  • Where can I get more information?

What is caspofungin (Cancidas)?

Caspofungin is an antibiotic that fights infections caused by fungus.

Caspofungin is used to treat fungal infections that involve the stomach, lungs, esophagus, or other internal body areas.

Caspofungin may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of caspofungin (Cancidas)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor right away if you have any of these serious side effects:

  • pain, swelling, or vein irritation where the medicine is injected;
  • fever, chills, body aches, flu symptoms;
  • swelling in your hands or feet;
  • weakness, muscle cramps, pounding or uneven heart beats; or
  • nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects include:

  • warmth, redness, or tingly feeling under your skin;
  • increased sweating;
  • mild nausea, diarrhea;
  • skin rash or itching; or
  • headache.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about caspofungin (Cancidas)?

Before receiving caspofungin, tell your doctor if you are allergic to any drugs, or if you have liver disease. You may need dosage adjustments or special tests during treatment.

Your doctor, nurse, or other healthcare provider will give you this injection in a clinic or hospital setting. You may be shown how to use your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of needles, IV tubing, and other items used in giving the medicine.

Caspofungin is usually given for at least 14 days. You may need to receive this medication until it has been at least 7 days after your symptoms disappear, or 14 days after lab tests show that the infection has cleared.

Serious side effects of caspofungin include swelling or vein irritation, fever, chills, body aches, flu symptoms, swelling in your hands or feet, muscle cramps, pounding or uneven heart beats, stomach pain with dark urine, or jaundice (yellowing of the skin or eyes). Tell your doctor right away if you have any of these side effects.

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