Chloramphenicol Sodium Succinate

DRUG DESCRIPTION

Chloramphenicol is an antibiotic that is clinically useful for, and should be reserved for, serious infections caused by organisms susceptible to its antimicrobial effects when less potentially hazardous therapeutic agents are ineffective or contraindicated. Sensitivity testing is essential to determine its indicated use, but may be performed concurrently with therapy initiated on clinical impression that one of the indicated conditions exists (see INDICATIONS AND USAGE section).

When reconstituted as directed, each vial contains a sterile solution equivalent to 100 mg of chloramphenicol per mL (1g/10mL).

Each gram (10 mL of a 10% solution) of chloramphenicol sodium succinate (chloramphenicol sodium succinate (chloramphenicol sodium succinate (chloramphenicol sodium succinate injection) injection) injection) contains approximately 52 mg (2.25 mEq) of sodium.

The chemical name for chloramphenicol sodium succinate (chloramphenicol sodium succinate (chloramphenicol sodium succinate (chloramphenicol sodium succinate injection) injection) injection) is D-threo-(-)-2, 2-Dichloro-N-[?- hydroxy-?-(hydroxymethyl)-p-nitrophenethyl] acetamide ?-(sodium succinate).

The empirical and structural formulas are:

Chloramphenicol Sodium Succinate Structural Formula Illustration


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