Dostinex

DRUG DESCRIPTION

DOSTINEX Tablets contain cabergoline, a dopamine receptor agonist. The chemical name for cabergoline is 1-[(6-allylergolin-8??-yl)-carbonyl]-1-[3-(dimethylamino) propyl]-3-ethylurea. Its empirical formula is C26H37N5O2, and its molecular weight is 451.62. The structural formula is as follows:

DOSTINEX® (cabergoline) Structural Formula Illustration

Cabergoline is a white powder soluble in ethyl alcohol, chloroform, and N, Ndimethylformamide (DMF); slightly soluble in 0.1N hydrochloric acid; very slightly soluble in n-hexane; and insoluble in water.

DOSTINEX Tablets, for oral administration, contain 0.5 mg of cabergoline. Inactive ingredients consist of leucine, USP, and lactose, NF.

What are the possible side effects of cabergoline (Dostinex)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using cabergoline and call your doctor at once if you have any of these serious side effects:

  • cough or trouble breathing; or
  • feeling light-headed, fainting.

Less serious side effects may include:

  • nausea, vomiting, stomach pain, constipation;
  • headache;
  • dizziness, drowsiness, nervousness;
  • ...

Read All Potential Side Effects and See Pictures of Dostinex »

What are the precautions when taking cabergoline (Dostinex)?

Before taking cabergoline, tell your doctor or pharmacist if you are allergic to it; or to other ergot medications (such as ergotamine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, high blood pressure (hypertension), heart valve disease, abnormal scarring/thickening of the lining in the lungs/heart/behind the abdomen (pulmonary/pericardial/retroperitoneal fibrosis).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit...

Read All Potential Precautions of Dostinex »


Dostinex Consumer (continued)

SIDE EFFECTS: Nausea, vomiting, stomach upset, constipation, dizziness, lightheadedness, or tiredness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these rare but serious side effects occur: shortness of breath, persistent cough, swelling ankles/feet, unusual tiredness, mental/mood changes (such as nervousness, compulsive behavior including urge to gamble), vision changes, painful menses, breast pain.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking cabergoline, tell your doctor or pharmacist if you are allergic to it; or to other ergot medications (such as ergotamine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, high blood pressure (hypertension), heart valve disease, abnormal scarring/thickening of the lining in the lungs/heart/behind the abdomen (pulmonary/pericardial/retroperitoneal fibrosis).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. However, this medication may affect breast milk production. Therefore, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.


Dostinex Patient Information Including Side Effects

Brand Names: Dostinex

Generic Name: cabergoline (Pronunciation: ca BER goe leen)

  • What is cabergoline (Dostinex)?
  • What are the possible side effects of cabergoline (Dostinex)?
  • What is the most important information I should know about cabergoline (Dostinex)?
  • What should I discuss with my health care provider before taking cabergoline (Dostinex)?
  • How should I take cabergoline (Dostinex)?
  • What happens if I miss a dose (Dostinex)?
  • What happens if I overdose (Dostinex)?
  • What should I avoid while taking cabergoline (Dostinex)?
  • What other drugs will affect cabergoline (Dostinex)?
  • Where can I get more information?

What is cabergoline (Dostinex)?

Cabergoline is in a group of drugs called dopamine receptor antagonists. It works by reducing the amount of prolactin (a hormone) that is released from the pituitary gland.

Cabergoline is used to treat a hormone imbalance in which there is too much prolactin in the blood (also called hyperprolactinemia).

Cabergoline may also be used for other purposes not listed in this medication guide.

What are the possible side effects of cabergoline (Dostinex)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using cabergoline and call your doctor at once if you have any of these serious side effects:

  • cough or trouble breathing; or
  • feeling light-headed, fainting.

Less serious side effects may include:

  • nausea, vomiting, stomach pain, constipation;
  • headache;
  • dizziness, drowsiness, nervousness;
  • numbness or tingly feeling; or
  • hot flashes.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about cabergoline (Dostinex)?

Do not use this medication if you are allergic to cabergoline, or if you have uncontrolled high blood pressure, pregnancy-related high blood pressure, or if you are allergic to any type of ergot medicine such as ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine).

Before taking cabergoline, tell your doctor if you are allergic to any drugs, or if you have liver disease, heart disease, or a breathing disorder.

Cabergoline is usually taken twice each week for at least 6 months. Do not take this medication every day unless your doctor tells you to.

To be sure this medication is helping your condition, your blood will need to be tested on a regular basis to measure your prolactin levels. Your doctor may want to continue checking your prolactin levels for several months after you stop taking cabergoline. Do not miss any scheduled visits.

Tell your doctor if you are also taking metoclopramide (Reglan), blood pressure medications, diuretics, or any medication to treat a psychiatric disorder.

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