Evoclin

DRUG DESCRIPTION

EVOCLIN (clindamycin phosphate) Foam contains clindamycin (1%) as clindamycin phosphate.

Clindamycin phosphate is a water-soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic, lincomycin.

The chemical name for clindamycin phosphate is methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)1-thio-L-threo-?-D-galacto-octopyranoside 2-(dihydrogen phosphate). The structural formula for clindamycin phosphate is represented below:

 EVOCLIN® (clindamycin phosphate) Structural Formula Illustration

Molecular Formula: C18H34ClN2O8PS      Molecular Weight: 504.97 g/mol

EVOCLIN Foam contains clindamycin (1%) as clindamycin phosphate, at a concentration equivalent to 10 mg clindamycin per gram in a thermolabile hydroethanolic foam vehicle consisting of cetyl alcohol, ethanol (58%), polysorbate 60, potassium hydroxide, propylene glycol, purified water, and stearyl alcohol pressurized with a hydrocarbon (propane/butane) propellant.

What are the possible side effects of clindamycin topical (Cleocin T, Clindagel, ClindaMax, ClindaReach Pledget, Evoclin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have any of these serious side effects:

  • severe redness, itching, or dryness of treat skin areas; or
  • diarrhea that is watery or bloody.

Less serious side effects may include:

  • mild burning or...

Read All Potential Side Effects and See Pictures of Evoclin »

What are the precautions when taking clindamycin phosphate (Evoclin)?

Before using clindamycin, tell your doctor or pharmacist if you are allergic to it; or to lincomycin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: chronic asthma or hay fever (atopic conditions), intestinal diseases (e.g., ulcerative colitis, enteritis).

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known if the medication in this product passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before...

Read All Potential Precautions of Evoclin »


Evoclin Consumer (continued)

SIDE EFFECTS: Burning, itching, dryness, redness, oily skin or skin peeling may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A small amount of this medication may be absorbed into your bloodstream and may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a resistant bacteria. This condition may occur while receiving treatment or even weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have the following symptoms because these products may make them worse. Tell your doctor immediately if you develop persistent diarrhea, abdominal or stomach pain/cramping, or blood/mucus in your stool.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using clindamycin, tell your doctor or pharmacist if you are allergic to it; or to lincomycin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: chronic asthma or hay fever (atopic conditions), intestinal diseases (e.g., ulcerative colitis, enteritis).

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known if the medication in this product passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.


Evoclin Patient Information Including Side Effects

Brand Names: Cleocin T, Clindagel, ClindaMax, ClindaReach Pledget, Evoclin

Generic Name: clindamycin topical (Pronunciation: klin da MYE sin)

  • What is clindamycin topical (Evoclin)?
  • What are the possible side effects of clindamycin topical (Evoclin)?
  • What is the most important information I should know about clindamycin topical (Evoclin)?
  • What should I discuss with my healthcare provider before using clindamycin topical (Evoclin)?
  • How should I use clindamycin topical (Evoclin)?
  • What happens if I miss a dose (Evoclin)?
  • What happens if I overdose (Evoclin)?
  • What should I avoid while taking clindamycin topical (Evoclin)?
  • What other drugs will affect clindamycin topical (Evoclin)?
  • Where can I get more information?

What is clindamycin topical (Evoclin)?

Clindamycin is an antibiotic. Clindamycin topical prevents bacteria from growing on the skin.

Clindamycin topical (for the skin) is used to treat severe acne.

Clindamycin topical may also be used for other purposes not listed in this medication guide.

What are the possible side effects of clindamycin topical (Evoclin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have any of these serious side effects:

  • severe redness, itching, or dryness of treat skin areas; or
  • diarrhea that is watery or bloody.

Less serious side effects may include:

  • mild burning or itching;
  • mild dryness of treated skin; or
  • redness or other irritation.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about clindamycin topical (Evoclin)?

Use clindamycin topical exactly as your doctor has prescribed it for you. Using more medicine or applying it more often than prescribed will not make it work any faster, and may increase side effects. Do not use this medication for longer than your doctor has prescribed.

Avoid getting this medication in your eyes. If it does get into your eyes, rinse thoroughly with water.

It may take several weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve.

Although this medicine is applied to the skin, your body may absorb enough clindamycin to cause serious side effects. You may not be able to use this medication if you have inflammation of your intestines (also called enteritis), ulcerative colitis, or if you have ever had severe diarrhea caused by antibiotic medicine.

Related Drug Centers
  • Evoclin
  • Cleocin T


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