CeeNU

DRUG DESCRIPTION

CeeNU® (lomustine) (CCNU) is one of the nitrosoureas used in the treatment of certain neoplastic diseases. It is 1-(2-chloro-ethyl)-3-cyclohexyl-1-nitrosourea. It is a yellow powder with the empirical formula of C9H16ClN3O2 and a molecular weight of 233.71. CeeNU is soluble in 10% ethanol (0.05 mg per mL) and in absolute alcohol (70 mg per mL). CeeNU is relatively insoluble in water ( < 0.05 mg per mL).

It is relatively un-ionized at a physiological pH.

Inactive ingredients in CeeNU Capsules are magnesium stearate and mannitol.

The structural formula is:

CeeNU® (lomustine) Structural Formula Illustration

CeeNU is available in 10 mg, 40 mg, and 100 mg capsules for oral administration.

What are the possible side effects of lomustine (Ceenu)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • signs of infection such as fever, chills, sore throat, easy bruising or bleeding;
  • wheezing, rapid breathing, feeling short of breath;
  • chest pain, dry cough, fever, feeling ill;
  • urinating less than usual or not at all;
  • confusion, mood changes, increased...

Read All Potential Side Effects and See Pictures of CeeNU »

What are the precautions when taking lomustine capsules (CeeNU)?

Before taking lomustine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: current infection.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood disorder (e.g., anemia, clotting problem), kidney disease, liver disease, lung disease.

Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or...

Read All Potential Precautions of CeeNU »


CeeNU Consumer (continued)

SIDE EFFECTS: Nausea, vomiting, loss of appetite, diarrhea, and mouth/lip sores may occur. Nausea and vomiting usually last for less than 24 hours, though loss of appetite can last for several days. Nausea and vomiting can be quite severe. In some cases, your doctor may prescribe medication to prevent/treat nausea and vomiting. Changes in diet such as eating several small meals or limiting activity may help decrease some of these effects. If these effects persist or worsen, notify your doctor or pharmacist promptly.

Temporary hair loss may occur. Normal hair growth should return after treatment has ended.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. (See also Warning section.)

Tell your doctor immediately if any of these unlikely but serious side effects occur: confusion, swelling of lower legs/feet, vision changes.

Tell your doctor immediately if any of these rare but very serious side effects occur: coughing up blood, persistent nausea/vomiting, stomach/abdominal pain, black tarry stools, unusual tiredness, change in the amount of urine, dark or pink urine, yellow eyes/skin.

A severe (sometimes fatal) lung problem (pulmonary fibrosis) has occurred in patients using this drug. This condition can occur months to years after you start taking this medication. Tell your doctor immediately if you experience any of these serious side effects: cough, chest pain, difficult/painful breathing.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking lomustine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: current infection.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood disorder (e.g., anemia, clotting problem), kidney disease, liver disease, lung disease.

Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose. To prevent the spread of infections, wash your hands well, and avoid touching your eyes or the inside of your nose without first washing your hands.

To lower your risk of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

Limit alcoholic beverages as drinking alcohol may increase your chances of bleeding in your stomach or intestines.

During pregnancy, lomustine should be used only when clearly needed. It may harm an unborn baby. If you become pregnant or think you may be pregnant, inform your doctor immediately. Women of childbearing age should use 2 forms of birth control while using this medication. Discuss the use of birth control, the risks and benefits of this medication, and any other concerns about using this medication with your doctor.

It is not known whether this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.


CeeNU Patient Information Including Side Effects

Brand Names: Ceenu

Generic Name: lomustine (Pronunciation: LOE mus teen)

  • What is lomustine (CeeNU)?
  • What are the possible side effects of lomustine (CeeNU)?
  • What is the most important information I should know about lomustine (CeeNU)?
  • What should I discuss with my healthcare provider before taking lomustine (CeeNU)?
  • How should I take lomustine (CeeNU)?
  • What happens if I miss a dose (CeeNU)?
  • What happens if I overdose (CeeNU)?
  • What should I avoid while taking lomustine (CeeNU)?
  • What other drugs will affect lomustine (CeeNU)?
  • Where can I get more information?

What is lomustine (CeeNU)?

Lomustine is a cancer medication that interferes with the growth of cancer cells and slows their spread in the body.

Lomustine is used to treat brain tumors and Hodgkin's disease.

Lomustine is sometimes given with other cancer medications.

Lomustine may also be used for other purposes not listed in this medication guide.

What are the possible side effects of lomustine (CeeNU)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • signs of infection such as fever, chills, sore throat, easy bruising or bleeding;
  • wheezing, rapid breathing, feeling short of breath;
  • chest pain, dry cough, fever, feeling ill;
  • urinating less than usual or not at all;
  • confusion, mood changes, increased thirst;
  • swelling in your ankles or feet;
  • jaundice (yellowing of the skin or eyes); or
  • white patches or sores inside your mouth or on your lips.

Less serious side effects may include:

  • loss of appetite, nausea, vomiting;
  • temporary hair loss;
  • vision problems; or
  • feeling weak or tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about lomustine (CeeNU)?

Do not use lomustine if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

You should not use this medication if you are allergic to lomustine.

Before taking lomustine, tell your doctor if you have bone marrow suppression, liver or kidney disease, or a history of lung or breathing problems.

Lomustine is usually taken once every 6 weeks. To get the correct dose, you may need to take 2 or more capsules that are different types and colors. Follow your doctor's dosing instructions very carefully.

Lomustine can cause nausea and vomiting or loss of appetite. Taking lomustine on an empty stomach may reduce nausea and vomiting. Call your doctor if you vomit right after taking a lomustine capsule.

To be sure this medication is not causing harmful effects, your blood will need to be tested weekly for at least 6 weeks after you take lomustine. Your kidneys, liver, and lung function may also need to be tested. Do not miss any follow-up visits to your doctor.

Wear disposable rubber gloves when you handle a lomustine capsule. Throw the gloves away after one use.

Do not use a lomustine capsule that has been accidentally opened or broken. The medicine from inside the capsule can be dangerous if it gets on your skin. If skin contact occurs, wash the area with soap and water or rinse the eyes thoroughly with plain water.

Related Drug Centers
  • Ceenu


Related Drugs Index: