BenzaClin

DRUG DESCRIPTION

BenzaClin® Topical Gel (clindamycin and benzoyl peroxide) contains clindamycin phosphate, (7(S)-chloro-7deoxylincomycin-2-phosphate). Clindamycin phosphate is a water soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic lincomycin.

Chemically, clindamycin phosphate is (C18H34ClN2O8PS). The structural formula for clindamycin is represented below:

Clindamycin phosphate Structural Formula Illustration

Clindamycin phosphate has molecular weight of 504.97 and its chemical name is Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans- 4-propyl-L-2-pyrrolidinecarboxamido) - 1-thio-L- threo-alpha-D- galacto-octopyranoside 2-(dihydrogen phosphate).

BenzaClin (clindamycin and benzoyl peroxide) Topical Gel also contains benzoyl peroxide, for topical use. Chemically, benzoyl peroxide is (C14H10O4). It has the following structural formula:

Benzoyl peroxide has a molecular weight of 242.23.

Each gram of BenzaClin (clindamycin and benzoyl peroxide) Topical Gel contains, as dispensed, 10 mg (1%) clindamycin as phosphate and 50 mg (5%) benzoyl peroxide in a base of carbomer, sodium hydroxide, dioctyl sodium sulfosuccinate, and purified water.

What are the possible side effects of benzoyl peroxide and clindamycin topical?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have any of these serious side effects:

  • severe redness, burning, stinging, or peeling of treat skin areas; or
  • diarrhea that is watery or bloody.

Less serious side effects may include:

  • mild burning or stinging;
  • itching or tingly...

Read All Potential Side Effects and See Pictures of BenzaClin »

What are the precautions when taking clindamycin and benzoyl peroxide (BenzaClin)?

Before using this medication, tell your doctor or pharmacist if you are allergic to benzoyl peroxide; or to clindamycin; or to lincomycin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: intestinal disorders (e.g., regional enteritis, ulcerative colitis, antibiotic-associated colitis, Clostridium difficile-associated diarrhea).

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when...

Read All Potential Precautions of BenzaClin »


BenzaClin Consumer (continued)

SIDE EFFECTS: Dry skin, redness, burning, itching, or skin peeling may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

You can use skin moisturizing creams or lotions to help reduce many of the side effects listed above.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may be absorbed into your bloodstream and very rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to resistant bacteria. This condition may occur weeks after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have the following symptoms because these products may make them worse. Tell your doctor immediately if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using this medication, tell your doctor or pharmacist if you are allergic to benzoyl peroxide; or to clindamycin; or to lincomycin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: intestinal disorders (e.g., regional enteritis, ulcerative colitis, antibiotic-associated colitis, Clostridium difficile-associated diarrhea).

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.

This medication may bleach hair or colored fabric. Avoid contact with hair or clothing.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This drug may pass into breast milk and could have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.


BenzaClin Patient Information Including Side Effects

Brand Names: BenzaClin, BenzaClin with pump, Duac, Duac Care System, Z-Clinz 10, Z-Clinz 5

Generic Name: benzoyl peroxide and clindamycin topical (Pronunciation: BEN zoyl per OX ide and clin da MYE sin)

  • What is benzoyl peroxide and clindamycin topical (BenzaClin)?
  • What are the possible side effects of benzoyl peroxide and clindamycin topical?
  • What is the most important information I should know about benzoyl peroxide and clindamycin topical?
  • What should I discuss with my healthcare provider before using benzoyl peroxide and clindamycin topical?
  • How should I use benzoyl peroxide and clindamycin topical?
  • What happens if I miss a dose?
  • What happens if I overdose?
  • What should I avoid while taking benzoyl peroxide and clindamycin topical?
  • What other drugs will affect benzoyl peroxide and clindamycin topical?
  • Where can I get more information?

What is benzoyl peroxide and clindamycin topical (BenzaClin)?

Benzoyl peroxide has an antibacterial effect. It also has a mild drying effect that allows excess oil and dirt to be washed away.

Clindamycin is an antibiotic. Clindamycin topical prevents bacteria from growing on the skin.

Together the combination of benzoyl peroxide and clindamycin topical are used to treat acne.

Benzoyl peroxide and clindamycin topical may also be used for other purposes not listed in this medication guide.

What are the possible side effects of benzoyl peroxide and clindamycin topical?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have any of these serious side effects:

  • severe redness, burning, stinging, or peeling of treat skin areas; or
  • diarrhea that is watery or bloody.

Less serious side effects may include:

  • mild burning or stinging;
  • itching or tingly feeling;
  • dryness or peeling of treated skin; or
  • redness or other irritation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about benzoyl peroxide and clindamycin topical?

Use benzoyl peroxide and clindamycin topical exactly as your doctor has prescribed it for you. Using more medicine or applying it more often than prescribed will not make it work any faster, and may increase side effects. Do not use this medication for longer than your doctor has prescribed.

Avoid getting this medication in your eyes, mouth, or nose (or in the creases of your nose), or on your lips. If it does get into any of these areas, wash with water. Do not apply this medicine to sunburned, windburned, dry, chapped, irritated, or broken skin.

It may take several weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve.

Although this medicine is applied to the skin, your body may absorb enough clindamycin to cause serious side effects. You may not be able to use this medication if you have inflammation of your intestines (also called enteritis), ulcerative colitis, or if you have ever had severe diarrhea caused by antibiotic medicine.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Benzoyl peroxide and clindamycin topical can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

Related Drug Centers
  • BenzaClin
  • Duac


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