Clorpres

DRUG DESCRIPTION

CLORPRES (clonidine hydrochloride and chlorthalidone) is a combination of clonidine hydrochloride (a centrally acting antihypertensive agent) and chlorthalidone (a diuretic).

CLORPRES (clonidine hydrochloride and chlorthalidone) is available as tablets for oral administration in three dosage strengths: 0.1 mg/15 mg, 0.2 mg/15 mg and 0.3 mg/15 mg of clonidine hydrochloride/chlorthalidone, respectively.

The inactive ingredients are ammonium chloride, colloidal silicon dioxide, croscarmellose sodium (Type A), magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, D&C yellow #10.

Clonidine Hydrochloride

Clonidine hydrochloride is an imidazoline derivative and exists as a mesomeric compound. The chemical name is 2-[(2,6-dichlorophenyl)imino]imidazoline monohydrochloride. The following are the structural formula, molecular formula and molecular weight:

Clonidine Hydrochloride Structural Formula Illustration

Clonidine hydrochloride is an odorless, bitter, white crystalline substance soluble in water and alcohol.

Chlorthalidon

Chlorthalidone is a monosulfamyl diuretic that differs chemically from thiazide diuretics in that a double ring system is incorporated in its structure. It is 2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl) benzenesulfonamide with the following structural formula, molecular formula and molecular weight:

Chlorthalidone is practically insoluble in water, in ether and in chloroform; soluble in methanol; slightly soluble in alcohol.

What are the possible side effects of clonidine and chlorthalidone (Clorpres)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • dry mouth, increased thirst, drowsiness, restless feeling, nausea, vomiting, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting, or seizure (convulsions);
  • easy bruising or bleeding, unusual weakness;
  • red or purple spots...

Read All Potential Side Effects and See Pictures of Clorpres

What are the precautions when taking clonidine hydrochloride and chlorthalidone (Clorpres)?

Before taking this medication, tell your doctor or pharmacist if you are allergic to clonidine or chlorthalidone; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe kidney disease (inability to make urine).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, blood circulation problem (e.g., Raynaud's disease, stroke), depression, gout, heart disease (e.g., irregular heartbeat, recent heart attack, chest pain, heart failure), kidney disease,...

Read All Potential Precautions of Clorpres


Clorpres Consumer (continued)

SIDE EFFECTS: Dizziness, drowsiness, dry mouth, headache, constipation, weakness, tiredness, or increased urination may occur as your body adjusts to the medication. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This drug can lead to serious water and mineral loss (dehydration). Tell your doctor immediately if you have any of these unlikely but serious symptoms of dehydration: loss of appetite, confusion, severe dizziness/fainting, unusual dry mouth/thirst, severe headache, fast/irregular heartbeat, muscle cramps/spasms, nausea/vomiting, numbness/tingling, restlessness, seizure, decrease in amount of urine, unusual weakness/tiredness.

Tell your doctor immediately if any of these unlikely but serious side effects occur: slow heartbeat, joint pain (e.g., big toe pain), decreased sexual function, swelling of the hands/feet, unusual weight gain.

Tell your doctor immediately if any of these rare but very serious side effects occur: easy bleeding/bruising, signs of infection (e.g., fever, persistent sore throat), persistent nausea/vomiting, severe stomach/abdominal pain, pale stool, yellowing of eyes/skin, difficult urination, dark urine.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking this medication, tell your doctor or pharmacist if you are allergic to clonidine or chlorthalidone; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe kidney disease (inability to make urine).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, blood circulation problem (e.g., Raynaud's disease, stroke), depression, gout, heart disease (e.g., irregular heartbeat, recent heart attack, chest pain, heart failure), kidney disease, liver disease, systemic lupus erythematosus (SLE).

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Significant loss of body water from too much sweating, vomiting, or diarrhea can worsen dizziness. Drink plenty of fluids to prevent dehydration. If you are on restricted fluid intake, consult your doctor for further instructions. Tell your doctor if you are unable to drink fluids or if you have persistent diarrhea/vomiting.

Before having surgery, tell your doctor or dentist that you are using this medication.

If you have diabetes, this medication may make it more difficult to control your blood sugar levels. Check your blood sugar regularly as directed by your doctor. Inform your doctor of the results. Tell your doctor immediately if you have symptoms of high blood sugar such as increased thirst/urination. Your doctor may need to adjust your anti-diabetic medication or diet.

This medication can increase sensitivity to sunlight. Avoid prolonged sun exposure. Wear protective clothing and use a sunscreen.

Contact lens wearers may need to use appropriate lubricating solutions if this medication causes dry eyes.

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at greater risk for side effects while using this drug, especially dehydration.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This drug passes into breast milk and could have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.


Clorpres Patient Information Including Side Effects

Brand Names: Clorpres

Generic Name: clonidine and chlorthalidone (Pronunciation: KLOE ni deen and klor THAL i done)

  • What is clonidine and chlorthalidone (Clorpres)?
  • What are the possible side effects of clonidine and chlorthalidone (Clorpres)?
  • What is the most important information I should know about clonidine and chlorthalidone (Clorpres)?
  • What should I discuss with my doctor before taking clonidine and chlorthalidone (Clorpres)?
  • How should I take clonidine and chlorthalidone (Clorpres)?
  • What happens if I miss a dose (Clorpres)?
  • What happens if I overdose (Clorpres)?
  • What should I avoid while taking clonidine and chlorthalidone (Clorpres)?
  • What other drugs will affect clonidine and chlorthalidone (Clorpres)?
  • Where can I get more information?

What is clonidine and chlorthalidone (Clorpres)?

Clonidine lowers blood pressure by decreasing the levels of certain chemicals in your blood. This allows your blood vessels to relax and your heart to beat more slowly and easily.

Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

The combination of clonidine and chlorthalidone treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen. This medication is also used to treat high blood pressure (hypertension).

Clonidine and chlorthalidone may also be used for other purposes not listed in this medication guide.

What are the possible side effects of clonidine and chlorthalidone (Clorpres)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • dry mouth, increased thirst, drowsiness, restless feeling, nausea, vomiting, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting, or seizure (convulsions);
  • easy bruising or bleeding, unusual weakness;
  • red or purple spots on your skin;
  • confusion, hallucinations;
  • urinating more or less than usual, or not at all;
  • feeling short of breath, even with mild exertion;
  • swelling, rapid weight gain;
  • numbness or tingly feeling; or
  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • dry mouth, loss of appetite;
  • diarrhea, constipation, upset stomach;
  • dizziness, drowsiness;
  • headache;
  • feeling restless or nervous;
  • sleep problems (insomnia);
  • nightmares or unusual dreams;
  • breast swelling or tenderness;
  • mild itching or skin rash; or
  • impotence or loss of interest in sex.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about clonidine and chlorthalidone (Clorpres)?

Do not use this medication if you are unable to urinate.

Before using this medication, tell your doctor if you are allergic to sulfa drugs, or if you have liver disease, kidney disease, asthma, allergies, gout, lupus, or diabetes.

Avoid drinking alcohol, which can increase some of the side effects of clonidine and chlorthalidone.

Do not stop using this medication suddenly without first talking to your doctor. Stopping this medication suddenly can cause nervousness, anxiety, severe high blood pressure, or life-threatening symptoms. You will need to use less and less before you stop the medication completely.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to the side effects of clonidine and chlorthalidone.

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Keep using clonidine and chlorthalidone as directed, even if you feel well. High blood pressure often has no symptoms, so you may not know when your blood pressure is high. You may need to use blood pressure medication for the rest of your life.

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