Cogentin

DRUG DESCRIPTION

Benztropine mesylate is a synthetic compound containing structural features found in atropine and diphenhydramine.

It is designated chemically as 8-azabicyclo[3.2.1] octane, 3-(diphenylmethoxy)-,endo, methanesulfonate. Its empirical formula is C21H25NO•CH4O3S, and its structural formula is:

Benztropine mesylate structural formula illustration

Benztropine mesylate is a crystalline white powder, very soluble in water, and has a molecular weight of 403.54. COGENTIN* (Benztropine Mesylate) is supplied as a sterile injection for intravenous and intramuscular use.

Each milliliter of the injection contains:

Benztropine mesylate ..........1 mg
Sodium chloride ...............9 mg
Water for injection q.s. . ....1 mL

What are the possible side effects of benztropine (Cogentin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using benztropine and call your doctor at once if you have a serious side effect such as:

  • high fever;
  • headache, dizziness, weakness, and hot dry skin with no sweating;
  • feeling like you might pass out;
  • severe stomach pain;
  • chest pain, fast or uneven heart rate;
  • painful or difficult swallowing;
  • ...

Read All Potential Side Effects and See Pictures of Cogentin »

What are the precautions when taking benztropine mesylate injection (Cogentin)?

Before taking benztropine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain eye problem (narrow-angle glaucoma), blockage of the bladder/esophagus/stomach/intestines (e.g., bowel obstruction), severe ulcerative colitis.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: alcohol use, breathing problems (e.g., asthma, emphysema), diarrhea caused by an infection, certain eye problem...

Read All Potential Precautions of Cogentin »


Cogentin Consumer (continued)

SIDE EFFECTS: Drowsiness, dizziness, constipation, flushing, nausea, nervousness, blurred vision, or dry mouth may occur. These effects usually lessen as your body gets used to the medicine. If any of these effects persist or worsen, contact your doctor or pharmacist promptly.

To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: high fever, decreased sexual ability, severe stomach/abdominal pain, difficult/painful swallowing, difficulty urinating, vision changes, weakness.

Seek immediate medical attention if any of these very unlikely but very serious side effects occur: chest pain, severe dizziness/fainting, fast/irregular/slow heartbeat, mental/mood changes (e.g., confusion, hallucinations, memory problems).

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking benztropine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain eye problem (narrow-angle glaucoma), blockage of the bladder/esophagus/stomach/intestines (e.g., bowel obstruction), severe ulcerative colitis.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: alcohol use, breathing problems (e.g., asthma, emphysema), diarrhea caused by an infection, certain eye problem (open-angle glaucoma), heart problems (e.g., angina, heart attack, heart failure, fast/irregular heartbeat), high/low blood pressure, intestinal problems (e.g., chronic constipation, ileus, ulcerative colitis), kidney disease, liver disease, mental/mood problems (e.g., anxiety, dementia, psychosis), certain muscle disease (myasthenia gravis), certain nerve disease (autonomic neuropathy), seizure, stomach problems (e.g., acid reflux, hiatal hernia, ulcer), stroke, overactive thyroid (hyperthyroidism), problems urinating (e.g., due to enlarged prostate, neurogenic bladder).

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Avoid alcoholic beverages.

To minimize dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

This medication decreases saliva production, an effect that can increase gum and tooth problems (e.g., cavities, gum disease). Take special care with your dental hygiene (e.g., brushing, flossing) and have regular dental check-ups.

This drug can cause decreased sweating, which could cause a severe rise in your body temperature (hyperthermia). The risk of this serious side effect is greater in hot weather, during vigorous exercise, and/or if you drink alcohol. Drink plenty of fluids and dress lightly while in hot weather and when exercising. If you experience signs of hyperthermia such as mental/mood changes, headache, or dizziness, promptly seek cool or air-conditioned shelter and/or stop exercising, and seek immediate medical attention. Consult your doctor for more details.

The elderly may be more sensitive to the effects of this drug, especially dizziness, heatstroke, memory problems, and constipation.

Children may be more sensitive to the effects of this drug, especially effects on heart rate.

This drug should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known if this drug passes into breast milk. Consult your doctor before breast-feeding.


Cogentin Patient Information Including Side Effects

Brand Names: Cogentin

Generic Name: benztropine (Pronunciation: BENZ troe peen)

  • What is benztropine (Cogentin)?
  • What are the possible side effects of benztropine (Cogentin)?
  • What is the most important information I should know about benztropine (Cogentin)?
  • What should I discuss with my healthcare provider before taking benztropine (Cogentin)?
  • How should I take benztropine (Cogentin)?
  • What happens if I miss a dose (Cogentin)?
  • What happens if I overdose (Cogentin)?
  • What should I avoid while taking benztropine (Cogentin)?
  • What other drugs will affect benztropine (Cogentin)?
  • Where can I get more information?

What is benztropine (Cogentin)?

Benztropine reduces the effects of certain chemicals in the body that may become unbalanced as a result of disease (such as Parkinson's), drug therapy, or other causes.

Benztropine is used to treat the symptoms of Parkinson's disease, such as muscle spasms, stiffness, sweating, drooling, and poor muscle control. Benztropine is also used to treat and prevent these symptoms when they are caused by drugs such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), and others.

Benztropine may also be used for other purposes not listed in this medication guide.

What are the possible side effects of benztropine (Cogentin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using benztropine and call your doctor at once if you have a serious side effect such as:

  • high fever;
  • headache, dizziness, weakness, and hot dry skin with no sweating;
  • feeling like you might pass out;
  • severe stomach pain;
  • chest pain, fast or uneven heart rate;
  • painful or difficult swallowing;
  • impotence, trouble having an orgasm;
  • urination problems;
  • changes in your vision; or
  • confusion, unusual thoughts or behavior, hallucinations.

Less serious side effects may include:

  • drowsiness, feeling nervous;
  • nausea, vomiting, constipation;
  • dry mouth, nose, or throat, decreased sweating;
  • blurred vision, increased sensitivity to light; or
  • warmth, redness, or tingly feeling under your skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about benztropine (Cogentin)?

You should not take this medication if you are allergic to benztropine, or if you are also taking a medication called pramlintide (Symlin).

Before you take benztropine, tell if you have glaucoma, kidney or liver disease, heart disease, high blood pressure, a history of heart attack or stroke, a breathing disorder, a nerve or muscle disorder, seizures, urination problems, overactive thyroid, mental illness, or a stomach or intestinal disorder.

Avoid taking a diarrhea medication or antacid within 2 hours before or after you take benztropine. Also avoid taking ketoconazole (Nizoral) within 2 hours after you take benztropine.

Benztropine can cause side effects that may impair your vision, thinking, or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Benztropine can decrease perspiration and you may be more prone to heat stroke.

Do not stop taking this medication without first talking to your doctor. Stopping suddenly may make your condition worse. You may need to use less and less before you stop the medication completely.

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