Celontin

DRUG DESCRIPTION

Celontin (methsuximide) is an anticonvulsant succinimide, chemically designated as N,2-Dimethyl-2phenylsuccinimide, with the following structural formula:

Celontin® (Methsuximide) Structural Formula Illustration

Each Celontin capsule contains 150 mg or 300 mg methsuximide, USP. Also contains starch, NF. The capsule contains colloidal silicon dioxide, NF; D&C yellow No. 10; FD&C yellow No. 6; gelatin, NF; and sodium lauryl sulfate, NF.

What are the possible side effects of methsuximide (Celontin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have a serious side effect such as:

  • signs of infection such as fever,...

Read All Potential Side Effects and See Pictures of Celontin »

What are the precautions when taking methsuximide (Celontin)?

Before taking methsuximide, tell your doctor or pharmacist if you are allergic to it; or to ethosuximide; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems, kidney problems.

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this...

Read All Potential Precautions of Celontin »


Celontin Consumer (continued)

SIDE EFFECTS: Drowsiness, dizziness, stomach/abdominal pain, loss of appetite, nausea, vomiting, weight loss, diarrhea, headache, or loss of coordination may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A small number of people who take anticonvulsants for any condition (such as seizure, bipolar disorder, pain) may experience depression, suicidal thoughts/attempts, or other mental/mood problems. Tell your doctor immediately if you or your family/caregiver notice any unusual/sudden changes in your mood, thoughts, or behavior including signs of depression, suicidal thoughts/attempts, thoughts about harming yourself.

Tell your doctor immediately if any of these rare but very serious side effects occur: signs of infection (such as fever, persistent sore throat), aching swollen joints, rash on nose and cheeks, severe tiredness, easy bruising/bleeding, rapid breathing.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking methsuximide, tell your doctor or pharmacist if you are allergic to it; or to ethosuximide; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems, kidney problems.

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.


Celontin Patient Information Including Side Effects

Brand Names: Celontin

Generic Name: methsuximide (Pronunciation: meth SUX i mide)

  • What is methsuximide (Celontin)?
  • What are the possible side effects of methsuximide (Celontin)?
  • What is the most important information I should know about methsuximide (Celontin)?
  • What should I discuss with my healthcare provider before taking methsuximide (Celontin)?
  • How should I take methsuximide (Celontin)?
  • What happens if I miss a dose (Celontin)?
  • What happens if I overdose (Celontin)?
  • What should I avoid while taking methsuximide (Celontin)?
  • What other drugs will affect methsuximide (Celontin)?
  • Where can I get more information?

What is methsuximide (Celontin)?

Methsuximide is an anti-epileptic medication, also called an anticonvulsant.

Methsuximide is used alone or in combination with other medications to treat absence seizures (also called "petit mal" seizures) in adults and children.

Methsuximide may also be used for other purposes not listed in this medication guide.

What are the possible side effects of methsuximide (Celontin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have a serious side effect such as:

  • signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), mouth sores, unusual weakness;
  • signs of liver damage, such as nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • joint pain or swelling with fever, swollen glands, muscle aches, chest pain;
  • patchy skin color, red spots, or a butterfly-shaped skin rash over your cheeks and nose (worsens in sunlight);
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
  • worsening of seizures.

Less serious side effects may include:

  • diarrhea, constipation;
  • hiccups, vomiting, weight loss;
  • dizziness, drowsiness, nervousness, confusion;
  • blurred vision;
  • sleep problems (insomnia); or
  • loss of balance or coordination.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about methsuximide (Celontin)?

Methsuximide can cause a decrease in many types of blood cells (white cells, red cells, platelets). Call your doctor at once if you have any unusual bleeding, weakness, or any signs of infection, even if these symptoms first occur after you have been using the medication for several months.

Methsuximide may also cause liver damage. Call your doctor if you have symptoms such as loss of appetite, stomach pain, or jaundice (yellowing of the skin or eyes).

You may have thoughts about suicide while taking this medication. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Do not stop taking methsuximide without first talking to your doctor, even if you feel better. You may have increased seizures if you stop taking methsuximide suddenly. You will need to use less and less before you stop the medication completely.

Contact your doctor if your seizures get worse or you have them more often while taking methsuximide.

Carry an ID card or wear a medical alert bracelet stating that you are taking methsuximide, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are taking a seizure medication.

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