Evoxac

DRUG DESCRIPTION

Cevimeline is cis-2'-methylspiro {1-azabicyclo [2.2.2] octane-3, 5' -[1,3] oxathiolane} hydro-chloride, hydrate (2:1). Its empirical formula is C10H17NOS•HCl•? H2O, and its structural formula is:

Evoxac (Cevimeline Hydrochloride) Structural Formula Illustration

Cevimeline has a molecular weight of 244.79. It is a white to off white crystalline powder with a melting point range of 201 to 203°C. It is freely soluble in alcohol and chloroform, very soluble in water, and virtually insoluble in ether. The pH of a 1% solution ranges from 4.6 to 5.6. Inactive ingredients include lactose monohydrate, hydroxypropyl cellulose, and magnesium stearate.

What are the possible side effects of cevimeline (Evoxac)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking cevimeline and call your doctor at once if you have any of these serious side effects:

  • shortness of breath, wheezing, or tightness in your chest;
  • chest pain, uneven heart rate;
  • attacks of severe stomach pain on the right side, extending up to your shoulder (sometimes worse after meals);
  • nausea and vomiting, bloating, fever,...

Read All Potential Side Effects and See Pictures of Evoxac »

What are the precautions when taking cevimeline hcl (Evoxac)?

Before taking cevimeline, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, chronic bronchitis, chronic obstructive pulmonary disease-COPD), certain eye conditions (such as night blindness, acute iritis, narrow-angle glaucoma), heart disease (such as chest pain, heart failure, heart attack, slow heartbeat), low or high blood pressure, liver problems, gallbladder disease (such as gallstones), kidney stones, mental/mood disorders (such as depression, psychoses,...

Read All Potential Precautions of Evoxac »


Evoxac Consumer (continued)

SIDE EFFECTS: See also Precautions.

Sweating, nausea, runny nose, flushing, frequent urge to urinate, dizziness, weakness, diarrhea, and blurred vision may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

This medication may cause an increase in tears. This can be helpful if you have dry eyes. Tell your doctor if runny eyes become a problem.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: slow/fast/irregular heartbeat, shakiness (tremor), fainting, lung problems (such as increased wheezing/cough/phlegm), mental/mood changes (such as confusion, agitation), severe stomach/abdominal pain.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking cevimeline, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, chronic bronchitis, chronic obstructive pulmonary disease-COPD), certain eye conditions (such as night blindness, acute iritis, narrow-angle glaucoma), heart disease (such as chest pain, heart failure, heart attack, slow heartbeat), low or high blood pressure, liver problems, gallbladder disease (such as gallstones), kidney stones, mental/mood disorders (such as depression, psychoses, thinking/understanding problems like dementia, Alzheimer's), stomach problems (such as chronic heartburn, ulcer).

Cevimeline may make you dizzy and cause vision problems, especially at night. Do not drive, use machinery, or do any activity that requires alertness or clear vision, especially at night, until you are sure you can perform such activities safely. Limit alcoholic beverages.

If cevimeline makes you sweat heavily, drink plenty of fluids so that you do not become dehydrated. If you are unable to drink enough fluids, talk with your doctor immediately.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Discuss the risks and benefits with your doctor before breast-feeding.


Evoxac Patient Information Including Side Effects

Brand Names: Evoxac

Generic Name: cevimeline (Pronunciation: se vi ME leen)

  • What is cevimeline (Evoxac)?
  • What are the possible side effects of cevimeline (Evoxac)?
  • What is the most important information I should know about cevimeline (Evoxac)?
  • What should I tell my healthcare provider before taking cevimeline (Evoxac)?
  • How should I take cevimeline (Evoxac)?
  • What happens if I miss a dose (Evoxac)?
  • What happens if I overdose (Evoxac)?
  • What should I avoid while taking cevimeline (Evoxac)?
  • What other drugs will affect cevimeline (Evoxac)?
  • Where can I get more information?

What is cevimeline (Evoxac)?

Cevimeline increases the secretions of the saliva and sweat glands in the body.

Cevimeline is used to treat dry mouth in people with Sjogren's Syndrome.

Cevimeline may also be used for other purposes not listed in this medication guide.

What are the possible side effects of cevimeline (Evoxac)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking cevimeline and call your doctor at once if you have any of these serious side effects:

  • shortness of breath, wheezing, or tightness in your chest;
  • chest pain, uneven heart rate;
  • attacks of severe stomach pain on the right side, extending up to your shoulder (sometimes worse after meals);
  • nausea and vomiting, bloating, fever, chills, and jaundice (yellowing of the skin or eyes);
  • swelling in your hands or feet;
  • eye pain or drainage;
  • fever, ear ache, flu symptoms; or
  • white patches or sores inside your mouth or on your lips.

Less serious side effects may include:

  • blurred vision, dry eyes;
  • excessive sweating or salivating, drooling;
  • runny or stuffy nose;
  • nausea, diarrhea, constipation, loss of appetite;
  • dry mouth;
  • muscle pain;
  • vaginal itching or discharge;

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about cevimeline (Evoxac)?

Do not take this medication if you are allergic to cevimeline, or if you have untreated or uncontrolled asthma, glaucoma, or an eye condition called iritis or uveitis.

Before taking cevimeline, tell your doctor if you have heart disease, heart rhythm disorder, angina (chest pain), or a history of heart attack, high blood pressure (hypertension), asthma or other breathing disorder, or a history of kidney or gall stones.

Cevimeline can cause side effects that may impair your vision, especially at night. Be careful if you drive or do anything that requires you to be able to see clearly.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Cevimeline may cause excessive sweating and you may get dehydrated more easily while taking this medication. Follow your doctor's instructions about the type and amount of liquids you should drink.

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