Corvert

DRUG DESCRIPTION

CORVERT Injection (ibutilide fumarate injection) is an antiarrhythmic drug with predominantly class III (cardiac action potential prolongation) properties according to the Vaughan Williams Classification. Each milliliter of CORVERT Injection contains 0.1 mg of ibutilide fumarate (equivalent to 0.087 mg ibutilide free base), 0.189 mg sodium acetate trihydrate, 8.90 mg sodium chloride, hydrochloric acid to adjust pH to approximately 4.6, and Water for Injection.

CORVERT (ibutilide fumarate injection) Injection is an isotonic, clear, colorless, sterile aqueous solution. Ibutilide fumarate has one chiral center, and exists as a racemate of the (+) and (-) enantiomers.

The chemical name for ibutilide fumarate is Methanesulfonamide, N-{4-{4-(ethylheptylamino)-1-hydroxybutyl}phenyl}, (+) (-), (E)-2-butenedioate (1:0.5) (hemifumarate salt). Its molecular formula is C22H38N2O5S, and its molecular weight is 442.62.

Ibutilide fumarate is a white to off-white powder with an aqueous solubility of over 100 mg/mL at pH 7 or lower.

The structural formula is represented below:

Corvert® (ibutilide fumarate) Structural Formula Illustration

What are the possible side effects of ibutilide (Corvert)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Your caregivers will watch you closely with a heart monitor and other medical devices to check for serious side effects. Tell your caregivers if you feel short of breath or like you might pass out.

Less serious side effects may include:

  • headache; or
  • nausea.

This is not a complete list of side effects and others may occur. Tell your...

Read All Potential Side Effects and See Pictures of Corvert »


Corvert Patient Information Including Side Effects

Brand Names: Corvert

Generic Name: ibutilide (Pronunciation: eye BUE til ide)

  • What is ibutilide (Corvert)?
  • What are the possible side effects of ibutilide (Corvert)?
  • What is the most important information I should know about ibutilide (Corvert)?
  • What should I discuss with my health care provider before receiving ibutilide (Corvert)?
  • How is ibutilide given (Corvert)?
  • What happens if I miss a dose (Corvert)?
  • What happens if I overdose (Corvert)?
  • What should I avoid after receiving ibutilide (Corvert)?
  • What other drugs will affect ibutilide (Corvert)?
  • Where can I get more information?

What is ibutilide (Corvert)?

Ibutilide is an anti-arrhythmic heart medication that corrects certain conditions of irregular heart rhythm.

Ibutilide is used to treat atrial fibrillation or atrial flutter. If not corrected, these heart rhythm disorders can lead to heart failure or stroke if not corrected.

Ibutilide may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of ibutilide (Corvert)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Your caregivers will watch you closely with a heart monitor and other medical devices to check for serious side effects. Tell your caregivers if you feel short of breath or like you might pass out.

Less serious side effects may include:

  • headache; or
  • nausea.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about ibutilide (Corvert)?

If possible, tell your doctor if you have taken a heart rhythm medication within the past 4 hours before receiving ibutilide.

In an emergency situation, it may not be possible to tell your caregivers that you are pregnant or breast-feeding before you are treated with ibutilide. However, make sure any doctor caring for your pregnancy or your baby knows that you have received the medication.

In some cases, your heart rhythm problem can occur again or get worse even after you are treated with ibutilide. This may be more likely if you have other problems such as congestive heart failure. However, every effort will be made to quickly treat any additional heart rhythm problems you may have.

During your treatment with ibutilide, you will be watched closely with heart monitoring equipment so that any further problems can be treated quickly. Cardiac emergency equipment will also be kept nearby in case it is needed to treat you.

Heart monitoring may continue for several hours after you have stopped receiving ibutilide.

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