Diphtheria and Tetanus

DRUG DESCRIPTION

Diphtheria and Tetanus Toxoids Adsorbed USP (For Pediatric Use) (DT), for intramuscular use, is a sterile suspension of alum-precipitated (aluminum potassium sulfate) toxoid in an isotonic sodium chloride solution. The vaccine, after shaking, is a turbid liquid, whitish-gray in color.

Corynebacterium diphtheriae cultures are grown in a modified Mueller and Miller medium.1 Clostridium tetani cultures are grown in a peptone-based medium containing bovine extract. The meat used in this medium is US sourced. Both toxins are detoxified with formaldehyde. The detoxified materials are then separately purified by serial ammonium sulfate fractionation and diafiltration. The 1 dose vial of vaccine is formulated without preservatives but contains a trace amount of thimerosal (a mercury [Hg] containing compound) from the manufacturing process (?0.3 mg Hg/0.5 mL dose).The multidose (5 mL) vial of vaccine contains the preservative thimerosal (25 mg Hg/0.5 mL dose).

Each 0.5 mL dose is formulated to contain 6.7 Lf of diphtheria toxoid,5 Lf of tetanus toxoid, and not more than 0.17 mg of aluminum. The residual formaldehyde content, by assay, is less than 0.02%.Both toxoids induce at least 2 units of antitoxin per mL in the guinea pig potency test.

REFERENCES

1. Mueller JH, et al. Production of diphtheria toxin of high potency (100 Lf) on a reproducible medium. J Immunol 40:21-32,1941

What are the possible side effects of diphtheria and tetanus vaccines (Diphtheria-Tetanus Toxoids, Pediatric)?

Getting diphtheria or tetanus disease is much riskier than getting the DT vaccines. However, a vaccine, like any medicine, is capable of causing serious problems, such as severe allergic reactions. The risk of DT vaccine causing serious harm, or death, is extremely small.

Seek emergency medical attention or contact your doctor immediately if any of the following rare but serious side effects from DT vaccine are experienced:

  • a serious allergic reaction including swelling of the...

Read All Potential Side Effects and See Pictures of Diphtheria and Tetanus


Diphtheria and Tetanus Patient Information Including Side Effects

Brand Names: Diphtheria-Tetanus Toxoids, Pediatric

Generic Name: diphtheria and tetanus toxoids vaccine (DT, pediatric) (Pronunciation: dif THEER ee a TET a nus TOX oids)

  • What is diphtheria and tetanus toxoids vaccine (Diphtheria and Tetanus)?
  • What are the possible side effects of this vaccine (Diphtheria and Tetanus)?
  • What is the most important information I should know about this vaccine (Diphtheria and Tetanus)?
  • What should I discuss with my healthcare provider before receiving this vaccine (Diphtheria and Tetanus)?
  • How is this vaccine given (Diphtheria and Tetanus)?
  • What happens if I miss a dose (Diphtheria and Tetanus)?
  • What happens if I overdose (Diphtheria and Tetanus)?
  • What should I avoid before or after receiving this vaccine (Diphtheria and Tetanus)?
  • What other drugs will affect diphtheria and tetanus toxoids vaccine (Diphtheria and Tetanus)?
  • Where can I get more information?

What is diphtheria and tetanus toxoids vaccine (Diphtheria and Tetanus)?

Diphtheria and tetanus are serious diseases caused by bacteria.

Diphtheria causes a thick coating in the nose, throat, and airways. It can lead to breathing problems, paralysis, heart failure, or death.

Tetanus (lockjaw) causes painful tightening of the muscles, usually all over the body. It can lead to "locking" of the jaw so the victim cannot open the mouth or swallow. Tetanus leads to death in about 1 out of 10 cases.

Diphtheria is spread from person to person. Tetanus enters the body through a cut or wound.

The diphtheria and tetanus toxoids vaccine (also called DT) is used to help prevent these diseases in children who are ages 6 weeks to 6 years old, before the child has reached his or her 7th birthday.

This vaccine works by exposing your child to a small dose of the bacteria or a protein from the bacteria, which causes the body to develop immunity to the disease. This vaccine will not treat an active infection that has already developed in the body.

Like any vaccine, the diphtheria and tetanus toxoids vaccine may not provide protection from disease in every person.

What are the possible side effects of this vaccine (Diphtheria and Tetanus)?

Your child should not receive a booster vaccine if he or she had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects your child has after receiving this vaccine. When the child receives a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with diphtheria or tetanus is much more dangerous to your child's health than receiving the vaccine to protect against these diseases. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

Get emergency medical help if your child has any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if the child has any of these serious side effects:

  • extreme drowsiness, fainting;
  • severe headache or vomiting;
  • fussiness, irritability, crying for an hour or longer;
  • confusion, seizure (black-out or convulsions); or
  • high fever.

Less serious side effects include:

  • redness, pain, tenderness, swelling, or a hard lump where the shot was given;
  • mild fever;
  • mild fussiness or crying;
  • joint pain, body aches;
  • mild drowsiness; or
  • mild vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.

What is the most important information I should know about this vaccine (Diphtheria and Tetanus)?

The diphtheria and tetanus toxoids vaccine is given in a series of shots. The first shot is usually given when the child is 2 months old. The booster shots are then given at 4 months, 6 months, and 12 to 18 months of age. A fifth booster dose is given between 4 and 6 years of age.

Your child's individual booster schedule may be different from these guidelines. Follow your doctor's instructions or the schedule recommended by the health department of the state you live in.

The pediatric version of this vaccine (DT) should not be given to anyone over the age of 6 years old. Another vaccine is available for use in older children and adults.

Be sure your child receives all recommended doses of this vaccine. If your child does not receive the full series of vaccines, he or she may not be fully protected against the disease.

Your child can still receive a vaccine if he or she has a cold or fever. In the case of a more severe illness with a fever or any type of infection, wait until the child gets better before receiving this vaccine.

Your child should not receive a booster vaccine if he or she had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects your child has after receiving this vaccine. When the child receives a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with diphtheria or tetanus is much more dangerous to your child's health than receiving the vaccine to protect against these diseases. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

Related Drug Centers
  • Diptheria and Tetanus


Related Drugs Index: