Dovonex Cream

DRUG DESCRIPTION

Dovonex® (calcipotriene cream) Cream, 0.005% contains calcipotriene monohydrate, a synthetic vitamin D3 derivative, for topical dermatological use.

Chemically, calcipotriene monohydrate is (5Z,7E,22E,24S)-24-cyclopropyl-9,10-secochola-5,7,10(19), 22-tetraene-1a,3b,24-triol monohydrate, with the empirical formula C27H40O3†H2O, a molecular weight of 430.6, and the following structural formula:

Calcipotriene monohydrate is a white or off-white crystalline substance. Dovonex Cream (calcipotriene cream) contains calcipotriene monohydrate equivalent to 50 µg/g anhydrous calcipotriene in a cream base of cetearyl alcohol, ceteth-20, diazolidinyl urea, dichlorobenzyl alcohol, dibasic sodium phosphate, edetate disodium, glycerin, mineral oil, petrolatum, and water.

What are the possible side effects of calcipotriene topical (Dovonex)?

Serious side effects are very rare. Stop using calcipotriene topical and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives).

You may experience some irritation of the skin, such as burning, itching, redness, swelling, dryness, or peeling while you are using calcipotriene topical. These side effects sometimes lessen with continued treatment. Notify your doctor if you experience these side effects.

If you notice...

Read All Potential Side Effects and See Pictures of Dovonex Cream »

What are the precautions when taking calcipotriene cream (Dovonex Cream)?

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: high calcium/vitamin D levels (hypercalcemia/hypervitaminosis D).

Before using this medication, tell your doctor or pharmacist your medical history.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors. Your doctor may direct you to...

Read All Potential Precautions of Dovonex Cream »


Dovonex Cream Consumer (continued)

SIDE EFFECTS: Burning, itching, rash, irritation, redness, dry skin, or peeling at the application site may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: skin thinning/discoloration, stretch marks, "hair bumps" (folliculitis), unusual tiredness, mental/mood changes, unexplained constipation.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: high calcium/vitamin D levels (hypercalcemia/hypervitaminosis D).

Before using this medication, tell your doctor or pharmacist your medical history.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors. Your doctor may direct you to limit or avoid phototherapy while you use this medication. Discuss this further with your doctor.

Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.


Dovonex Cream Patient Information Including Side Effects

Brand Names: Dovonex

Generic Name: calcipotriene topical (Pronunciation: cal sih poh TRY een)

  • What is calcipotriene topical (Dovonex Cream)?
  • What are the possible side effects of calcipotriene topical (Dovonex Cream)?
  • What is the most important information I should know about calcipotriene topical (Dovonex Cream)?
  • What should I discuss with my healthcare provider before using calcipotriene topical (Dovonex Cream)?
  • How should I use calcipotriene topical (Dovonex Cream)?
  • What happens if I miss a dose (Dovonex Cream)?
  • What happens if I overdose (Dovonex Cream)?
  • What should I avoid while using calcipotriene topical (Dovonex Cream)?
  • What other drugs will affect calcipotriene topical (Dovonex Cream)?
  • Where can I get more information?

What is calcipotriene topical (Dovonex Cream)?

Calcipotriene is a synthetic topical form of vitamin D. It is involved in the growth and development of skin cells.

Calcipotriene topical is used to treat plaque psoriasis (psoriasis with scaly patches).

Calcipotriene topical may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of calcipotriene topical (Dovonex Cream)?

Serious side effects are very rare. Stop using calcipotriene topical and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives).

You may experience some irritation of the skin, such as burning, itching, redness, swelling, dryness, or peeling while you are using calcipotriene topical. These side effects sometimes lessen with continued treatment. Notify your doctor if you experience these side effects.

If you notice a change in your skin color, contact your doctor.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about calcipotriene topical (Dovonex Cream)?

Use calcipotriene topical only on affected patches of the skin. Do not use calcipotriene topical on sunburned, windburned, dry, chapped, or irritated skin or on an open wound.

Avoid abrasive, harsh, or drying soaps and cleansers while using calcipotriene topical.

Do not use more than 100 grams of calcipotriene in a week.

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