Digitek

DRUG DESCRIPTION

DIGITEK (digoxin) is one of the cardiac (or digitalis) glycosides, a closely related group of drugs having in common specific effects on the myocardium. These drugs are found in a number of plants. Digoxin is extracted from the leaves of Digitalis lanata. The term "digitalis" is used to designate the whole group of glycosides. The glycosides are composed of two portions: a sugar and a cardenolide (hence "glycosides").

Digoxin is described chemically as (3 ?, 5 ?, 12 ?)-3-[(O-2, 6-dideoxy-?-D-ribo-hexopyranosyl-(1?4)-O-2,6-dideoxy-?-D-ribo-hexopyranosyl- (1?4)-2,6-dideoxy-?-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-card-20(22)-enolide. Its molecular formula is C41H64O14, its molecular weight is 780.94, and the structural formula shown:

DIGITEK (digoxin) structural formula illustration

Digoxin exists as odorless white crystals that melt with decomposition above 230C. The drug is practically insoluble in water and in ether; slightly soluble in diluted (50%) alcohol and in chloroform; and freely soluble in pyridine.

DIGITEK (digoxin tablets) is supplied as 125-mcg (0.125-mg) or 250-mcg (0.25-mg) tablets for oral administration. Each tablet contains the labeled amount of digoxin USP and the following inactive ingredients: corn starch, croscarmellose sodium, microcrystalline cellulose, pregelatinized starch, lactose monohydrate and anhydrous lactose, silicon dioxide and stearic acid. In addition, the 125-mcg (0.125-mg) tablet contains D&C Yellow No. 10 Aluminum Lake.

What are the possible side effects of digoxin (Digitek, Lanoxicaps, Lanoxin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • fast, slow, or uneven heart rate;
  • bloody or black, tarry stools;
  • blurred vision, yellowed vision; or
  • confusion, hallucinations, unusual thoughts or behavior.

Less serious side effects may include:

  • mild nausea,...

Read All Potential Side Effects and See Pictures of Digitek

What are the precautions when taking digoxin tablets (Digitek)?

Before taking digoxin, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as digitoxin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, thyroid problems (underactive or overactive).

The balance of certain natural minerals in your blood (calcium, magnesium, potassium) can affect how this drug works in your body. Certain drugs such as "water pills" (diuretics) may affect the normal balance of these minerals. Tell your doctor or pharmacist if you are taking a "water pill" or if you have a history of...

Read All Potential Precautions of Digitek


Digitek Consumer (continued)

SIDE EFFECTS: Nausea, vomiting, headache, loss of appetite, and diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: weakness, mental/mood changes, vision changes (such as blurred or yellow/green vision), enlarged/tender breasts in men.

Though this medication is used to treat a certain type of irregular heartbeat, it may infrequently cause other types of irregular heartbeats. Tell your doctor immediately if you notice any unusually fast/slow/irregular heartbeat.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking digoxin, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as digitoxin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, thyroid problems (underactive or overactive).

The balance of certain natural minerals in your blood (calcium, magnesium, potassium) can affect how this drug works in your body. Certain drugs such as "water pills" (diuretics) may affect the normal balance of these minerals. Tell your doctor or pharmacist if you are taking a "water pill" or if you have a history of mineral imbalance. Ask your doctor or pharmacist whether you should take a nutritional supplement or follow a special diet.

Before having surgery or certain procedures on your heart (such as electrical cardioversion), tell your doctor or dentist that you are using this medication.

Infants and children may be more sensitive to the effects of this drug, especially the effects on the heartbeat.

Tell your doctor if you are pregnant before using this medication.

Digoxin passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.


Digitek Patient Information Including Side Effects

Brand Names: Digitek, Lanoxicaps, Lanoxin

Generic Name: digoxin (oral) (Pronunciation: di JOX in)

  • What is digoxin (Digitek)?
  • What are the possible side effects of digoxin (Digitek)?
  • What is the most important information I should know about digoxin (Digitek)?
  • What should I discuss with my healthcare provider before taking digoxin (Digitek)?
  • How should I take digoxin (Digitek)?
  • What happens if I miss a dose (Digitek)?
  • What happens if I overdose (Digitek)?
  • What should I avoid while taking digoxin (Digitek)?
  • What other drugs will affect digoxin (Digitek)?
  • Where can I get more information?

What is digoxin (Digitek)?

Digoxin is derived from the leaves of a digitalis plant. Digoxin helps make the heart beat stronger and with a more regular rhythm.

Digoxin is used to treat congestive heart failure.

Digoxin is also used to treat atrial fibrillation, a heart rhythm disorder of the atria (the upper chambers of the heart that allow blood to flow into the heart).

Digoxin may also be used for other purposes not listed in this medication guide.

What are the possible side effects of digoxin (Digitek)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • fast, slow, or uneven heart rate;
  • bloody or black, tarry stools;
  • blurred vision, yellowed vision; or
  • confusion, hallucinations, unusual thoughts or behavior.

Less serious side effects may include:

  • mild nausea, vomiting, diarrhea;
  • feeling weak or dizzy;
  • headache;
  • enlarged breasts in men; or
  • mild skin rash.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about digoxin (Digitek)?

You should not use this medication if you are allergic to digoxin, or if you have ventricular fibrillation (a heart rhythm disorder of the ventricles, or lower chambers of the heart that allow blood to flow out of the heart).

Before using digoxin, tell your doctor if you have certain heart conditions, especially "AV block" (unless you have a pacemaker), or a recent history of heart attack. Also tell your doctor if you have kidney disease, a thyroid disorder, an electrolyte imbalance (such as low levels of calcium, potassium, or magnesium in your blood), or if you are malnourished or have recently been sick with vomiting or diarrhea.

Keep taking digoxin as directed, even if you feel well. Get your prescription refilled before you run out of medicine completely.

Do not stop taking digoxin without first talking to your doctor. Stopping suddenly may make your condition worse.

Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Digoxin overdose can occur more easily if you are dehydrated.

There are many other medicines that can interact with digoxin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Related Drug Centers
  • Digitek
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