Cardura

DRUG DESCRIPTION

CARDURA® (doxazosin mesylate) is a quinazoline compound that is a selective inhibitor of the alphai subtype of alpha-adrenergic receptors. The chemical name of doxazosin mesylate is l-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(l,4-benzodioxan-2-ylcarbonyl)piperazine methanesulfonate. The empirical formula for doxazosin mesylate is C23H25N5O5 • CH4O3S and the molecular weight is 547.6. It has the following structure:

CARDURA®
  (doxazosin mesylate) Structural Formula Illustration

CARDURA (doxazosin mesylate) is freely soluble in dimethylsulfoxide, soluble in dimethylformamide, slightly soluble in methanol, ethanol, and water (0.8% at 25 °C), and very slightly soluble in acetone and methylene chloride. CARDURA (doxazosin mesylate) is available as colored tablets for oral use and contains 1 mg (white), 2 mg (yellow), 4 mg (orange) and 8 mg (green) of doxazosin as the free base.

The inactive ingredients for all tablets are: microcrystalline cellulose, lactose, sodium starch glycolate, magnesium stearate and sodium lauryl sulfate. The 2 mg tablet contains D & C yellow 10 and FD & C yellow 6; the 4 mg tablet contains FD & C yellow 6; the 8 mg tablet contains FD & C blue 10 and D & C yellow 10.

What are the possible side effects of doxazosin (Cardura, Cardura XL)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • fast or pounding heartbeats;
  • feeling light-headed, fainting;
  • swelling in your hands, ankles, or feet; or
  • penis erection that is painful or lasts 4 hours or longer.

Less serious side effects may include:

  • weakness;
  • ...

Read All Potential Side Effects and See Pictures of Cardura »

What are the precautions when taking doxazosin mesylate (Cardura)?

Before taking doxazosin, tell your doctor or pharmacist if you are allergic to it; or to other alpha blockers such as prazosin and terazosin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: prostate cancer, heart disease (e.g., congestive heart failure, angina, heart attack in last 6 months), liver disease, kidney disease.

To minimize dizziness and lightheadedness, get up slowly when rising from a sitting or lying position, especially when you first start taking this drug or whenever your doctor changes your dose. Also, when you first start taking...

Read All Potential Precautions of Cardura »


Cardura Consumer (continued)

SIDE EFFECTS: Dizziness, lightheadedness, nausea, drowsiness, trouble sleeping, weight gain, joint/muscle pain, or decreased sexual ability/interest may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: vision changes, fainting, shortness of breath, weakness, pounding/irregular heartbeat, swelling of hands/feet, anxiety.

Tell your doctor immediately if any of these rare but very serious side effects occur: yellowing eyes/skin, dark urine, easy bleeding/bruising, fever, persistent sore throat.

Seek immediate medical attention if any of these rare but very serious side effects occur: chest pain, jaw/left arm pain, weakness on one side of the body, slurred speech, confusion.

For males, in the unlikely event you have a painful or prolonged erection lasting 4 or more hours, stop using this drug and seek immediate medical attention, or permanent problems could occur.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking doxazosin, tell your doctor or pharmacist if you are allergic to it; or to other alpha blockers such as prazosin and terazosin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: prostate cancer, heart disease (e.g., congestive heart failure, angina, heart attack in last 6 months), liver disease, kidney disease.

To minimize dizziness and lightheadedness, get up slowly when rising from a sitting or lying position, especially when you first start taking this drug or whenever your doctor changes your dose. Also, when you first start taking this drug, avoid situations where you may be injured if you faint.

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery (including cataract eye surgery), tell your doctor or dentist that you are taking this medication.

The elderly may be at greater risk for dizziness and low blood pressure while using this drug.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.


Cardura Patient Information Including Side Effects

Brand Names: Cardura, Cardura XL

Generic Name: doxazosin (Pronunciation: dox AY zo sin)

  • What is doxazosin (Cardura)?
  • What are the possible side effects of doxazosin (Cardura)?
  • What is the most important information I should know about doxazosin (Cardura)?
  • What should I discuss with my doctor before taking doxazosin (Cardura)?
  • How should I take doxazosin (Cardura)?
  • What happens if I miss a dose (Cardura)?
  • What happens if I overdose (Cardura)?
  • What should I avoid while taking doxazosin (Cardura)?
  • What other drugs will affect doxazosin (Cardura)?
  • Where can I get more information?

What is doxazosin (Cardura)?

Doxazosin is in a group of drugs called alpha-adrenergic blockers. Doxazosin causes the blood vessels (veins and arteries) to relax and expand, improving blood flow. Doxazosin also relaxes muscles in the prostate and bladder neck, making it easier to urinate.

Doxazosin is used to treat hypertension (high blood pressure) and benign prostatic hyperplasia (enlarged prostate).

Doxazosin may also be used for other purposes not listed in this medication guide.

What are the possible side effects of doxazosin (Cardura)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • fast or pounding heartbeats;
  • feeling light-headed, fainting;
  • swelling in your hands, ankles, or feet; or
  • penis erection that is painful or lasts 4 hours or longer.

Less serious side effects may include:

  • weakness;
  • headache;
  • dizziness; or
  • diarrhea, stomach pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about doxazosin (Cardura)?

You should not use this medication if you are allergic to doxazosin or similar medicines such as prazosin (Minipress), tamsulosin (Flomax), or terazosin (Hytrin).

Doxazosin lowers blood pressure and may cause dizziness or fainting, especially when you first start taking it, or when you start taking it again. To avoid falling, take the first dose of doxazosin at bedtime. You may wish to continue taking this medication only at bedtime if it causes you to feel light-headed.

You may feel very dizzy when you first wake up. Be careful when standing or sitting up from a lying position.

If you stopped taking doxazosin for any reason and have started taking it again, you may feel especially dizzy or light-headed after your first few doses.

Doxazosin can affect the pupils of your eyes during cataract surgery. If you have cataract surgery during your treatment with doxazosin, tell the surgeon ahead of time that you take doxazosin. Do not stop using the medication before surgery unless your surgeon tells you to.

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