VePesid

DRUG DESCRIPTION

VePesid® (etoposide) (also commonly known as VP-16) is a semisynthetic derivative of podophyllotoxin used in the treatment of certain neoplastic diseases. It is 4'-demethylepipodophyllotoxin 9-[4,6-O-(R)-ethylidene-?-D-glucopyranoside]. It is very soluble in methanol and chloroform, slightly soluble in ethanol, and sparingly soluble in water and ether. It is made more miscible with water by means of organic solvents. It has a molecular weight of 588.56 and a molecular formula of C29H32O13.

VePesid (etoposide) is administered orally. VePesid (etoposide) is available as 50 mg pink capsules. Each liquid-filled, soft gelatin capsule contains 50 mg of etoposide in a vehicle consisting of citric acid, glycerin, purified water, and polyethylene glycol 400. The soft gelatin capsules contain gelatin, glycerin, sorbitol, purified water, and parabens (ethyl and propyl) with the following dye system: iron oxide (red) and titanium dioxide; the capsules are printed with edible ink.

The structural formula is:

VePesid (etoposide)  Structural formula lilustration

What are the possible side effects of etoposide (VePesid)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • fever, chills, body aches, flu symptoms;
  • white patches or sores inside your mouth or on your lips;
  • easy bruising or bleeding, unusual weakness;
  • fast heart rate;
  • severe nausea and vomiting;
  • feeling light-headed, fainting; or
  • low...

Read All Potential Side Effects and See Pictures of VePesid »

What are the precautions when taking etoposide (VePesid)?

Before taking etoposide, tell your doctor or pharmacist if you are allergic to it or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, blood problems (e.g., anemia, thrombocytopenia), heart problems.

Do not have immunizations/vaccinations without the consent of your doctor and avoid contact with people who have recently received oral polio vaccine.

To lower the chance of getting cut, bruised or injured, use caution with sharp objects like safety razors or nail cutters, and avoid activities such as contact...

Read All Potential Precautions of VePesid »


VePesid Consumer (continued)

SIDE EFFECTS: (see also Warning section)

Nausea, vomiting, loss of appetite, strange aftertaste, diarrhea, mouth sores, muscle aches, drowsiness, fatigue, or skin color changes may occur. Nausea and vomiting can be quite severe. In some cases, drug therapy may be necessary to prevent or relieve nausea and vomiting. Changes in diet such as eating several small meals or limiting activity may help decrease some of these effects. If these effects persist or worsen, notify your doctor or pharmacist promptly.

Temporary hair loss may occur. Hair growth should return after treatment has ended.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Etoposide, along with certain other anti-cancer drugs, has been known to cause acute leukemia. This is very rare. Consult your doctor for more details.

Etoposide can lower the body's ability to fight an infection. Notify your doctor promptly if you develop any signs of an infection, such as fever, chills or persistent sore throat.

Tell your doctor immediately if this unlikely side effect occurs: tingling of hands or feet.

Tell your doctor immediately if any of these rare but very serious side effects occur: yellowing of the eyes or skin, tarry or bloody stool, vision changes, abdominal pain, redness or swelling of your veins.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, sweating, chest tightness, fast or irregular heartbeat, skin turning blue, cough, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking etoposide, tell your doctor or pharmacist if you are allergic to it or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, blood problems (e.g., anemia, thrombocytopenia), heart problems.

Do not have immunizations/vaccinations without the consent of your doctor and avoid contact with people who have recently received oral polio vaccine.

To lower the chance of getting cut, bruised or injured, use caution with sharp objects like safety razors or nail cutters, and avoid activities such as contact sports.

Wash your hands well to prevent the spread of infections.

This drug may make you drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.

Limit alcoholic beverages as drinking alcohol may increase your chances of bleeding in your stomach or intestines.

Caution is advised when using this drug in the elderly because they may be more sensitive to its effects.

Caution is advised when using etoposide in children because they may be more sensitive to the allergic effects of this drug.

Etoposide should be used during pregnancy only when clearly needed. It may cause harm to an unborn baby. If you become pregnant or think you may be pregnant, inform your doctor immediately. Women of child-bearing age should use an effective form of birth control while using this medication. Discuss the use of birth control, the risks, the benefits and any other concerns about using this medication with your doctor.

This medication passes into breast milk. Because of the potential risk to the infant, breast-feeding while using etoposide is not recommended. Consult your doctor before breast-feeding.


VePesid Patient Information Including Side Effects

Brand Names: VePesid

Generic Name: etoposide (oral) (Pronunciation: ee TOW poh side)

  • What is etoposide (VePesid)?
  • What are the possible side effects of etoposide (VePesid)?
  • What is the most important information I should know about etoposide (VePesid)?
  • What should I discuss with my healthcare provider before taking etoposide (VePesid)?
  • How should I use etoposide (VePesid)?
  • What happens if I miss a dose (VePesid)?
  • What happens if I overdose (VePesid)?
  • What should I avoid while using etoposide (VePesid)?
  • What other drugs will affect etoposide (VePesid)?
  • Where can I get more information?

What is etoposide (VePesid)?

Etoposide is a cancer medicine that interferes with the growth of cancer cells and slows their growth and spread in the body.

Etoposide is used to treat cancer of the lung or testicles.

Etoposide may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of etoposide (VePesid)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • fever, chills, body aches, flu symptoms;
  • white patches or sores inside your mouth or on your lips;
  • easy bruising or bleeding, unusual weakness;
  • fast heart rate;
  • severe nausea and vomiting;
  • feeling light-headed, fainting; or
  • low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Other, less serious side effects may be more likely to occur, such as:

  • mild nausea, vomiting, stomach pain;
  • mild itching or skin rash; or
  • temporary hair loss.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about etoposide (VePesid)?

Do not use this medication without your doctor's consent if you are pregnant. It could cause harm to the unborn baby. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.

Do not break or open an etoposide capsule. The medicine from a broken capsule can be dangerous if it gets in your eyes, mouth, or nose, or on your skin. If skin contact occurs, wash the area with soap and water or rinse the eyes thoroughly with plain water. If you must handle a broken capsule, ask your doctor or pharmacist how to safely dispose of the capsule.

Etoposide can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. It is important that you not miss any scheduled visits to your doctor.

Using etoposide may increase your risk of developing other types of cancer, such as leukemia. Talk with your doctor about your specific risk.

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