Etopophos

DRUG DESCRIPTION

ETOPOPHOS (etoposide phosphate) for Injection is an antineoplastic agent which is available for intravenous infusion as a sterile lyophile in single-dose vials containing etoposide phosphate equivalent to 100 mg etoposide, 32.7 mg sodium citrate USP, and 300 mg dextran 40.

Etoposide phosphate is a water soluble ester of etoposide (commonly known as VP-16), a semi-synthetic derivative of podophyllotoxin. The water solubility of etoposide phosphate lessens the potential for precipitation following dilution and during intravenous administration.

The chemical name for etoposide phosphate is:

4'-Demethylepipodophyllotoxin 9-[4,6-O-(R)-ethylidene-?-D-glucopyranoside], 4'-(dihydrogen phosphate).

Etoposide phosphate has the following structure:

ETOPOPHOS® (etoposide phosphate) Structural Formula Illustration

What are the possible side effects of etoposide phosphate (Etopophos)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • fever, chills, body aches, flu symptoms;
  • white patches or sores inside your mouth or on your lips;
  • pale skin, easy bruising or bleeding, unusual weakness;
  • feeling like you might pass out;
  • severe nausea and vomiting;
  • black, bloody,...

Read All Potential Side Effects and See Pictures of Etopophos »

What are the precautions when taking etoposide phosphate (Etopophos)?

Before using etoposide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Tell your doctor your medical history, especially of: current infections, certain virus illnesses (herpes, chickenpox), blood disorders (e.g., anemia, clotting problems), liver problems, kidney problems, previous radiation/chemotherapy treatment.

Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose.

Wash your hands well to prevent the spread of infections. Avoid contact with...

Read All Potential Precautions of Etopophos »


Etopophos Consumer (continued)

SIDE EFFECTS: See also Warning section.

Nausea, vomiting, diarrhea, muscle aches, tiredness, loss of appetite, and pain/redness at the injection site may occur. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting. Eating several small meals, not eating before treatment, or limiting activity may help lessen some of these effects. If these effects persist or worsen, tell your doctor or pharmacist promptly.

Temporary hair loss may occur. Normal hair growth should return after treatment has ended.

Many people using this medication may have serious side effects. However, your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. To lower your risk of serious side effects, your doctor will follow your condition closely and order lab tests.

Pain or sores in the mouth and throat may occur. Brush your teeth gently/carefully, avoid using mouthwash that contains alcohol, and rinse your mouth frequently with cool water mixed with baking soda or salt. It may also be best to eat soft, moist foods.

Tell your doctor right away if you have any serious side effects, including: numbness/tingling of hands/feet, bloody/black/tarry stool, coughing up blood, fast/irregular heartbeat, severe abdominal pain, dark urine, yellowing eyes/skin.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, fever/chills.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using etoposide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Tell your doctor your medical history, especially of: current infections, certain virus illnesses (herpes, chickenpox), blood disorders (e.g., anemia, clotting problems), liver problems, kidney problems, previous radiation/chemotherapy treatment.

Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose.

Wash your hands well to prevent the spread of infections. Avoid contact with people who have illnesses that may spread to others (e.g., flu, chickenpox).

To lower your chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at greater risk for side effects (e.g., dizziness, infection, bleeding) while using this drug.

This drug is not recommended for use during pregnancy. It may harm the unborn baby. If you become pregnant or think you may be pregnant, tell your doctor immediately. To avoid pregnancy, both males and females using this drug should use reliable form(s) of birth control (e.g., birth control pills, condoms) during treatment. Consult your doctor for details and to discuss effective forms of birth control.

It is not known whether this medication passes into breast milk. However, it may have undesirable effects on a nursing infant. Therefore, breast-feeding while using this medication is not recommended. Consult your doctor before breast-feeding.


Etopophos Patient Information Including Side Effects

Brand Names: Etopophos

Generic Name: etoposide phosphate (Pronunciation: e TOE poe side FOS fate)

  • What is etoposide phosphate (Etopophos)?
  • What are the possible side effects of etoposide phosphate (Etopophos)?
  • What is the most important information I should know about etoposide phosphate (Etopophos)?
  • What should I discuss with my health care provider before using etoposide phosphate (Etopophos)?
  • How is etoposide phosphate given (Etopophos)?
  • What happens if I miss a dose (Etopophos)?
  • What happens if I overdose (Etopophos)?
  • What should I avoid while receiving etoposide phosphate (Etopophos)?
  • What other drugs will affect etoposide phosphate (Etopophos)?
  • Where can I get more information?

What is etoposide phosphate (Etopophos)?

Etoposide phosphate is a cancer medicine that interferes with the growth of cancer cells and slows their growth and spread in the body.

Etoposide phosphate is used to treat cancer of the lung or testicles.

Etoposide phosphate may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of etoposide phosphate (Etopophos)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • fever, chills, body aches, flu symptoms;
  • white patches or sores inside your mouth or on your lips;
  • pale skin, easy bruising or bleeding, unusual weakness;
  • feeling like you might pass out;
  • severe nausea and vomiting;
  • black, bloody, or tarry stools; or
  • coughing up blood or vomit that looks like coffee grounds.

Less serious side effects may include:

  • mild nausea, vomiting, stomach pain, loss of appetite;
  • constipation, diarrhea;
  • dizziness, tired feeling;
  • change in your sense of taste;
  • temporary hair loss; or
  • mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about etoposide phosphate (Etopophos)?

Do not receive etoposide phosphate without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Before receiving etoposide phosphate, tell your doctor if you have kidney disease or a weak immune system.

Etoposide phosphate can lower the blood cells that help your body fight infections. Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.

To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis.

Do not receive a "live" vaccine while you are being treated with etoposide phosphate. Live vaccines include measles, mumps, rubella (MMR), oral polio, chickenpox (varicella), BCG (Bacillus Calmette and Gu?rin), and nasal flu vaccine.

Using etoposide phosphate may increase your risk of developing other types of cancer, such as leukemia. Talk with your doctor about your specific risk.

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