Foscavir

DRUG DESCRIPTION

FOSCAVIR is the brand name for foscarnet sodium. The chemical name of foscarnet sodium is phosphonoformic acid, trisodium salt. Foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with an empirical formula of Na3CO5P•6 H20 and a molecular weight of 300.1. The structural formula is:

FOSCAVIR® (foscarnet sodium)  Structural Formula Illustration

FOSCAVIR (foscarnet sodium injection) has the potential to chelate divalent metal ions, such as calcium and magnesium, to form stable coordination compounds. FOSCAVIR (foscarnet sodium injection) INJECTION is a sterile, isotonic aqueous solution for intravenous administration only. The solution is clear and colorless. Each milliliter of FOSCAVIR contains 24 mg of foscarnet sodium hexahydrate in Water for Injection, USP. Hydrochloric acid and/or sodium hydroxide may have been added to adjust the pH of the solution to 7.4. FOSCAVIR (foscarnet sodium injection) INJECTION contains no preservatives.

What are the possible side effects of foscarnet (Foscavir)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using foscarnet and call your doctor at once if you have any of these serious side effects:

  • urinating less than usual or not at all;
  • dry mouth, increased thirst, drowsiness, restless feeling, confusion, nausea, vomiting, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting, or seizure (convulsions);
  • ...

Read All Potential Side Effects and See Pictures of Foscavir »

What are the precautions when taking foscarnet sodium injection (Foscavir)?

Before using foscarnet, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, dehydration, low electrolyte levels (calcium, magnesium, potassium, phosphate), nervous system problems (e.g., seizure history), heart disease.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Caution is advised when using this drug in children...

Read All Potential Precautions of Foscavir »


Foscavir Consumer (continued)

SIDE EFFECTS: See also Warning section.

Because this medication is used in patients who use other medications, it is difficult to tell which side effects are caused by foscarnet. Nausea, vomiting, headache, diarrhea, dizziness, loss of appetite, and increased sweating have been reported. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes (e.g., depression, anxiety), new vision problems, muscle cramps/spasms, weakness, fast breathing, irregular heartbeat, change in the amount of urine, painful urination, vaginal sores, seizures, fever, persistent sore throat.

You may experience redness, irritation, or pain at the injection site. Tell your doctor if this occurs. Also tell your doctor if you experience tingling or numbness of the hands or feet, or tingling around your mouth during or after the infusion. Your doctor may need to adjust your dose.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using foscarnet, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, dehydration, low electrolyte levels (calcium, magnesium, potassium, phosphate), nervous system problems (e.g., seizure history), heart disease.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Caution is advised when using this drug in children because they may be more sensitive to the effects of the drug, especially the effects on developing bones.

Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug, especially the effects on the kidneys.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Because of the possible harm to the infant, breast-feeding is not recommended.


Foscavir Patient Information Including Side Effects

Brand Names: Foscavir

Generic Name: foscarnet (Pronunciation: fos KAR net)

  • What is foscarnet (Foscavir)?
  • What are the possible side effects of foscarnet (Foscavir)?
  • What is the most important information I should know about foscarnet (Foscavir)?
  • What should I discuss with my health care provider before using foscarnet (Foscavir)?
  • How is foscarnet given (Foscavir)?
  • What happens if I miss a dose (Foscavir)?
  • What happens if I overdose (Foscavir)?
  • What should I avoid while using foscarnet (Foscavir)?
  • What other drugs will affect foscarnet (Foscavir)?
  • Where can I get more information?

What is foscarnet (Foscavir)?

Foscarnet is an antiviral medication that prevents certain virus cells from multiplying in your body.

Foscarnet is used to treat cytomegalovirus (CMV) retinitis in people with AIDS. Foscarnet is not a cure for CMV, and the virus may progress during or after treatment.

Foscarnet is also used to treat herpes simplex virus (HSV) in people with a weak immune system. Foscarnet is usually given for HSV after other antiviral medications have been tried without successful treatment.

Foscarnet may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of foscarnet (Foscavir)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using foscarnet and call your doctor at once if you have any of these serious side effects:

  • urinating less than usual or not at all;
  • dry mouth, increased thirst, drowsiness, restless feeling, confusion, nausea, vomiting, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting, or seizure (convulsions);
  • fever, chills, body aches, flu symptoms;
  • pale skin, easy bruising or bleeding;
  • numbness or tingling around your mouth or in your hands or feet;
  • restless muscle movements in your eyes, tongue, jaw, or neck;
  • trouble breathing; or
  • pain or burning when you urinate.

Keep using foscarnet and talk with your doctor if you have any of these less serious side effects:

  • anxiety, confusion, depressed mood;
  • nausea, stomach pain, vomiting;
  • headache, dizziness;
  • cough;
  • increased sweating;
  • skin rash;
  • problems with vision;
  • weakness, tired feeling;
  • joint or muscle pain; or
  • pain or swelling where the injection was given.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about foscarnet (Foscavir)?

Foscarnet is not a cure for CMV, and the virus may progress during or after treatment.

Before using foscarnet, tell your doctor if you have kidney disease, a seizure disorder, heart disease, a nerve disorder, or an electrolyte imbalance such as low calcium, potassium, or magnesium.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney function may also need to be tested, and you may also need regular eye exams. Do not miss any scheduled visits to your doctor.

Stop using foscarnet and call your doctor at once if you urinate less than usual or not at all, or if you have numbness or tingling around your mouth, uncontrolled muscle movements, or pain or burning when you urinate.

There are many other medicines that can cause kidney damage or lower calcium levels and should not be used together with foscarnet. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

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