Fansidar

DRUG DESCRIPTION

Fansidar (sulfadoxine and pyrimethamine) is an antimalarial agent, each tablet containing 500 mg N1-(5,6-dimethoxy-4-pyrimidinyl) sulfanilamide (sulfadoxine) and 25 mg 2,4-diamino-5-(p-chlorophenyl)-6-ethylpyrimidine (pyrimethamine). Each tablet also contains cornstarch, gelatin, lactose, magnesium stearate and talc.

Sulfadoxine Structural Formula Illustration

What are the possible side effects of pyrimethamine and sulfadoxine (Fansidar)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using pyrimethamine and sulfadoxine and call your doctor at once if you have any of these serious side effects:

  • the first sign of any skin rash, no matter how mild;
  • a severe blistering, peeling, and red skin rash;
  • pale skin, easy bruising or bleeding;
  • feeling tired, weak, or dizzy;
  • hallucinations,...

Read All Potential Side Effects and See Pictures of Fansidar

What are the precautions when taking sulfadoxine and pyrimethamine (Fansidar)?

Before taking sulfadoxine/pyrimethamine, tell your doctor or pharmacist if you are allergic to either sulfadoxine or pyrimethamine; or to other "sulfa" drugs (such as sulfamethoxazole, sulfisoxazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding problems (such as low platelets), low red blood cell count (anemia), low white blood cell count, severe allergy or breathing problems (asthma), seizures, kidney problems, liver problems, low folic acid levels (such as problems with absorption of food, alcoholism), a certain enzyme problem...

Read All Potential Precautions of Fansidar


Fansidar Consumer (continued)

SIDE EFFECTS: See also Warning section.

Nausea, vomiting, or headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: swollen/painful tongue, mental/mood changes (such as depression, hallucinations, nervousness), unusually quick sunburn (photosensitivity).

Tell your doctor immediately if any of these rare but very serious side effects occur: lower abdominal/back pain, bloody/pink urine, change in amount of urine, painful urination, chest pain, irregular heartbeat, signs of severe liver problems (such as severe tiredness, persistent nausea/vomiting, yellowing skin/eyes, abdominal pain, dark urine).

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking sulfadoxine/pyrimethamine, tell your doctor or pharmacist if you are allergic to either sulfadoxine or pyrimethamine; or to other "sulfa" drugs (such as sulfamethoxazole, sulfisoxazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding problems (such as low platelets), low red blood cell count (anemia), low white blood cell count, severe allergy or breathing problems (asthma), seizures, kidney problems, liver problems, low folic acid levels (such as problems with absorption of food, alcoholism), a certain enzyme problem (glucose-6-phosphate dehydrogenase deficiency-G6PD), a certain blood disorder (porphyria).

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details.

This drug passes into breast milk. Due to the possibility of severe side effects in your nursing infant, avoid breast-feeding while taking sulfadoxine/pyrimethamine. Consult your doctor before breast-feeding.


Fansidar Patient Information Including Side Effects

Brand Names: Fansidar

Generic Name: pyrimethamine and sulfadoxine (Pronunciation: PIR i METH a meen and SUL fa DOX een)

  • What is pyrimethamine and sulfadoxine (Fansidar)?
  • What are the possible side effects of pyrimethamine and sulfadoxine (Fansidar)?
  • What is the most important information I should know about pyrimethamine and sulfadoxine (Fansidar)?
  • What should I discuss with my health care provider before taking pyrimethamine and sulfadoxine (Fansidar)?
  • How should I take pyrimethamine and sulfadoxine (Fansidar)?
  • What happens if I miss a dose (Fansidar)?
  • What happens if I overdose (Fansidar)?
  • What should I avoid while taking pyrimethamine and sulfadoxine (Fansidar)?
  • What other drugs will affect pyrimethamine and sulfadoxine (Fansidar)?
  • Where can I get more information?

What is pyrimethamine and sulfadoxine (Fansidar)?

Pyrimethamine is an antiparasitic drug. It prevents the growth and reproduction of parasites.

Sulfadoxine is a sulfa drug that fights bacteria in the body.

The combination of pyrimethamine and sulfadoxine is used to treat malaria, a disease caused by parasites. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

Pyrimethamine and sulfadoxine is usually given when other anti-malaria medications may not be as effective in treatment or prevention.

Pyrimethamine and sulfadoxine may also be used for purposes not listed in this medication guide.

What are the possible side effects of pyrimethamine and sulfadoxine (Fansidar)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using pyrimethamine and sulfadoxine and call your doctor at once if you have any of these serious side effects:

  • the first sign of any skin rash, no matter how mild;
  • a severe blistering, peeling, and red skin rash;
  • pale skin, easy bruising or bleeding;
  • feeling tired, weak, or dizzy;
  • hallucinations, seizure (convulsions);
  • urinating less than usual or not at all;
  • jaundice (yellowing of the skin or eyes); or
  • fever, chills, sore throat, swollen tongue, joint pain, cough, feeling short of breath.

Less serious side effects may include:

  • mild stomach pain, feeling full;
  • slight hair loss;
  • headache;
  • muscle weakness;
  • depression, nervousness;
  • ringing in your ears; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about pyrimethamine and sulfadoxine (Fansidar)?

Do not use this medication if you have ever had a serious allergic reaction to pyrimethamine or sulfadoxine. Stop taking the medicine and call your doctor at once if you have any signs of skin rash, no matter how mild.

You should not use this medication if you are allergic to sulfa drugs, or if you have liver or kidney disease (if using the medication long-term), a blood cell disorder (such as anemia), if you are in late pregnancy, or if you are breast-feeding a baby.

Take the pyrimethamine and sulfadoxine tablet after a meal, with plenty of water or other fluid. Swallow the tablet whole, do not break or chew it.

Drink plenty of water to keep your kidneys working and prevent kidney stones while taking this medication.

You should not take pyrimethamine and sulfadoxine for longer than 2 years without a doctor's advice.

In addition to taking pyrimethamine and sulfadoxine, use protective clothing, insect repellents, and mosquito netting around your bed to further prevent mosquito bites that could cause malaria.

No medication is 100% effective in treating or preventing malaria. For best results, keep using the medication as directed. Talk with your doctor if you have fever, vomiting, or diarrhea during your treatment.

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