Sancuso

DRUG DESCRIPTION

Sancuso contains granisetron, which is an anti-nauseant and antiemetic agent. Chemically it is 1methyl-N-[(1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide with a molecular weight of 312.4. Its empirical formula is C18H24N4O, while its chemical structure is:

Granisetron

Sancuso (Granisetron) Structural Formula Illustration

Granisetron is a white to off-white solid that is insoluble in water. Sancuso is a thin, translucent, matrix-type transdermal patch that is rectangular-shaped with rounded corners, consisting of a backing, the drug matrix and a release liner.

What are the possible side effects of transdermal granisetron (Sancuso)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Remove the skin patch and call your doctor at once if you have a serious side effect such as:

  • severe redness, itching, swelling, or other irritation where the patch is worn;
  • uneven heart rate;
  • fever, pale skin, easy bruising or bleeding; or
  • feeling like you might pass out.

Less serious side effects may...

Read All Potential Side Effects and See Pictures of Sancuso

What are the precautions when taking granisetron transdermal system (Sancuso)?

Before using granisetron, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: stomach/intestinal problems (such as ileus, swelling).

This medication may be affected by sunlight or may make the application site more sensitive to sunlight. While wearing the patch, keep it covered (such as under clothing) to avoid exposing it to sunlight and sunlamps. Avoid tanning booths. After removing the patch, keep the application site covered for another 10 days.

During pregnancy, this medication...

Read All Potential Precautions of Sancuso


Sancuso Consumer (continued)

SIDE EFFECTS: Constipation may occur. If this effect persists or worsens, tell your doctor promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if this unlikely but serious side effect occurs: stomach/abdominal pain or swelling.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using granisetron, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: stomach/intestinal problems (such as ileus, swelling).

This medication may be affected by sunlight or may make the application site more sensitive to sunlight. While wearing the patch, keep it covered (such as under clothing) to avoid exposing it to sunlight and sunlamps. Avoid tanning booths. After removing the patch, keep the application site covered for another 10 days.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.


Sancuso Patient Information Including Side Effects

Brand Names: Sancuso

Generic Name: granisetron (transdermal) (Pronunciation: gra NIS e tron)

  • What is transdermal granisetron (Sancuso)?
  • What are the possible side effects of transdermal granisetron (Sancuso)?
  • What is the most important information I should know about transdermal granisetron (Sancuso)?
  • What should I discuss with my healthcare provider before using granisetron (Sancuso)?
  • How should I use transdermal granisetron (Sancuso)?
  • What happens if I miss a dose (Sancuso)?
  • What happens if I overdose (Sancuso)?
  • What should I avoid while using transdermal granisetron (Sancuso)?
  • What other drugs will affect transdermal granisetron (Sancuso)?
  • Where can I get more information?

What is transdermal granisetron (Sancuso)?

Granisetron blocks the actions of chemicals in the body that may cause nausea and vomiting.

Granisetron transdermal (skin patch) is used to prevent nausea and vomiting caused by cancer chemotherapy.

Granisetron may also be used for other purposes not listed in this medication guide.

What are the possible side effects of transdermal granisetron (Sancuso)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Remove the skin patch and call your doctor at once if you have a serious side effect such as:

  • severe redness, itching, swelling, or other irritation where the patch is worn;
  • uneven heart rate;
  • fever, pale skin, easy bruising or bleeding; or
  • feeling like you might pass out.

Less serious side effects may include:

  • diarrhea, constipation;
  • nausea, vomiting, stomach pain;
  • loss of appetite;
  • headache;
  • mild itching or skin irritation where the patch is worn;
  • dizziness, drowsiness, anxiety;
  • sleep problems (insomnia); or
  • temporary hair loss.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about transdermal granisetron (Sancuso)?

You should not use this medication if you are allergic to granisetron.

Before using granisetron, tell your doctor if you have a stomach or intestinal disorder, if you have recently had stomach or intestinal surgery, or if you have ever had an allergic reaction to any type of medicated skin patch. You may need a dose adjustment or special tests to safely use granisetron.

Avoid exposing the skin patch or your upper arm to sunlight, sunlamps, or tanning beds. Natural or artificial sunlight can cause a skin reaction where the granisetron skin patch is worn. This effect may last for up to 10 days after the patch is removed. Wear protective clothing over your arms while you are wearing the skin patch and for at least 10 days after you remove a patch.

Do not use granisetron during a time when you are not having chemotherapy, unless your doctor has told you to.

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