Factrel

DRUG DESCRIPTION

An agent for use in evaluating hypothalamic-pituitary gonadotropic function. Factrel (gonadorelin hydrochloride) injectable is available as a sterile lyophilized powder for reconstitution and administration by subcutaneous or intravenous routes.

Chemical Name: 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl -L- tyrosyl-glycyl -L- leucyl-L-arginyl-L-prolyl glycinamide hydrochloride

 

Factrel (gonadorelin) is C 55 H 75 N 17 O 13 HCl, as the mono- or dihydrochloride, or their mixture. The gonadorelin base has a molecular weight of 1182.33. It is a white powder, soluble in alcohol and water, hygroscopic and moisture-sensitive, and stable at room temperature. The synthetic decapeptide, Factrel (gonadorelin) , has a chemical composition and structure identical to the natural hormone, identified from porcine or ovine hypothalami.

Each Secule® vial of Factrel contains 100 or 500 mcg gonadorelin as the hydrochloride, with 100 mg lactose, USP. Each ampul of sterile diluent contains 2% benzyl alcohol in sterile water.

What are the possible side effects of gonadorelin (Factrel)?

If you experience a rare allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives) to gonadorelin, seek emergency medical attention.

Other less serious side effects may also occur. Notify your doctor if you experience

  • headache;
  • flushing;
  • nausea or abdominal discomfort;
  • dizziness or lightheadedness;
  • pain, swelling, or itching at the injection site; or
  • skin rash.

Side effects other than those listed...

Read All Potential Side Effects and See Pictures of Factrel »


Factrel Patient Information Including Side Effects

Brand Names: Factrel

Generic Name: gonadorelin (injectable) (Pronunciation: gon ah doe REH lin)

  • What is gonadorelin (Factrel)?
  • What are the possible side effects of gonadorelin (Factrel)?
  • What is the most important information I should know about gonadorelin (Factrel)?
  • What should I discuss with my healthcare provider before taking gonadorelin (Factrel)?
  • How should I take gonadorelin (Factrel)?
  • What happens if I miss a dose (Factrel)?
  • What happens if I overdose (Factrel)?
  • What should I avoid while taking gonadorelin (Factrel)?
  • What other drugs will affect gonadorelin (Factrel)?
  • Where can I get more information?

What is gonadorelin (Factrel)?

Gonadorelin is a man-made protein that is like a hormone in the body called gonadotropin-releasing hormone (GnRH). GnRH causes the pituitary gland to release other hormones including luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH and FSH are important for proper development in children and fertility in adults.

Gonadorelin is used to test how well the hypothalamus and pituitary glands are working.

Gonadorelin may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of gonadorelin (Factrel)?

If you experience a rare allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives) to gonadorelin, seek emergency medical attention.

Other less serious side effects may also occur. Notify your doctor if you experience

  • headache;
  • flushing;
  • nausea or abdominal discomfort;
  • dizziness or lightheadedness;
  • pain, swelling, or itching at the injection site; or
  • skin rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What is the most important information I should know about gonadorelin (Factrel)?

Before using gonadorelin, tell your doctor if you have any other medical conditions or if you take any medications, including herbal products. You may not be able to take gonadorelin, or you may require a dosage adjustment or special monitoring.

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