Guanfacine Hydrochloride

DRUG DESCRIPTION

Guanfacine hydrochloride (guanfacine) is a centrally acting antihypertensive with a2-adrenoceptor agonist properties in tablet form for oral administration.

The chemical name of guanfacine hydrochloride (guanfacine) is N-Amidino-2-(2,6-dichlorophenyl) acetamide monohydrochloride and its molecular weight is 282.55. Its structural formula is:

Guanfacine Hydrochloride structural formula illustration
C9H9CI2N3O•HCI

Guanfacine hydrochloride (guanfacine) is a white to off-white powder; sparingly soluble in water and alcohol and slightly soluble in acetone.

Each tablet, for oral administration, contains guanfacine hydrochloride equivalent to 1 mg or 2 mg guanfacine. The tablets contain the following inactive ingredients:

1 mg - anhydrous lactose, FD&C Red 40 aluminum lake, microcrystalline cellulose, povidone, stearic acid.
2 mg - anhydrous lactose, D&C Yellow 10 aluminum lake, FD&C Red 40 aluminum lake, microcrystalline cellulose, povidone, stearic acid.

What are the possible side effects of guanethidine and hydrochlorothiazide (Esimil)?

If you experience any of the following serious side effects, stop taking guanethidine and hydrochlorothiazide and seek emergency medical attention:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • a very irregular heartbeat;
  • heart failure (shortness of breath, swelling of ankles or legs, sudden weight gain of 5 pounds or more);
  • chest pain;
  • little or no urine;
  • unusual fatigue;
  • ...

Read All Potential Side Effects and See Pictures of Guanfacine Hydrochloride »


Guanfacine Hydrochloride Patient Information Including Side Effects

Brand Names: Esimil

Generic Name: guanethidine and hydrochlorothiazide (Pronunciation: gwhan ETH i deen and hye droe klor oh THYE a zide)

  • What is guanethidine and hydrochlorothiazide (Guanfacine Hydrochloride)?
  • What are the possible side effects of guanethidine and hydrochlorothiazide (Guanfacine Hydrochloride)?
  • What is the most important information I should know about guanethidine and hydrochlorothiazide (Guanfacine Hydrochloride)?
  • Who should not take guanethidine and hydrochlorothiazide (Guanfacine Hydrochloride)?
  • How should I take guanethidine and hydrochlorothiazide (Guanfacine Hydrochloride)?
  • What happens if I miss a dose (Guanfacine Hydrochloride)?
  • What happens if I overdose (Guanfacine Hydrochloride)?
  • What should I avoid while taking guanethidine and hydrochlorothiazide (Guanfacine Hydrochloride)?
  • What other drugs will affect guanethidine and hydrochlorothiazide (Guanfacine Hydrochloride)?
  • Where can I get more information?

What is guanethidine and hydrochlorothiazide (Guanfacine Hydrochloride)?

Guanethidine lowers blood pressure by decreasing the levels of certain chemicals in your blood. This allows your blood vessels (veins and arteries) to relax and your heart to beat more slowly and easily.

Hydrochlorothiazide is a thiazide diuretic (water pill). It helps to lower your blood pressure and decrease edema (swelling) by increasing the amount of salt and water you lose in your urine.

Guanethidine and hydrochlorothiazide is used to treat high blood pressure.

Guanethidine and hydrochlorothiazide may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of guanethidine and hydrochlorothiazide (Guanfacine Hydrochloride)?

If you experience any of the following serious side effects, stop taking guanethidine and hydrochlorothiazide and seek emergency medical attention:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • a very irregular heartbeat;
  • heart failure (shortness of breath, swelling of ankles or legs, sudden weight gain of 5 pounds or more);
  • chest pain;
  • little or no urine;
  • unusual fatigue;
  • abnormal bleeding or bruising;
  • yellow skin or eyes;
  • confusion;
  • fainting; or
  • uncontrollable hand, arm, or leg movements.

Other, less serious side effects are more likely to occur. Continue to take guanethidine and hydrochlorothiazide and talk to your doctor if you experience

  • fatigue or drowsiness;
  • dizziness (avoid standing up too quickly and use caution when performing hazardous activities);
  • anxiety, depression or nightmares;
  • diarrhea, nausea, vomiting, or an acid stomach (take guanethidine and hydrochlorothiazide with food or milk if it upsets your stomach);
  • abdominal pain;
  • a stuffy nose or a dry mouth (sucking on ice chips or sugarless hard candy may relieve a dry mouth);
  • blurred vision;
  • tingling or numbness in your arms, legs, hands, or feet;
  • excessive urination;
  • muscle weakness or cramps;
  • increased hunger or thirst;
  • weight gain;
  • sensitivity to sunlight; or
  • impotence or difficulty ejaculating.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What is the most important information I should know about guanethidine and hydrochlorothiazide (Guanfacine Hydrochloride)?

Stand up slowly from a sitting or lying position. Guanethidine and hydrochlorothiazide may make you feel dizzy.

Do not stop taking guanethidine and hydrochlorothiazide suddenly. Even if you feel better, you need this medication to control your condition. Stopping suddenly could cause severe high blood pressure, anxiety, and other dangerous side effects.

Tell your doctor and dentist that you are taking this medication before having surgery.

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