GlucaGen

DRUG DESCRIPTION

GlucaGen (glucagon [rDNA origin] for injection) is an antihypoglycemic agent and a gastrointestinal motility inhibitor. It is produced by expression of recombinant DNA in a Saccharomyces cerevisiae vector with subsequent purification. The chemical structure of the glucagon in GlucaGen is identical to human glucagon and to glucagon extracted from beef and pork pancreas. Glucagon with the empirical formula of C153H225N43O49S, and a molecular weight of 3483, is a single-chain polypeptide containing 29 amino acid residues. The structure of glucagon is:

The structure of glucagon - Illustration

GlucaGen is a sterile, lyophilized white powder in a 2 mL vial. The reconstituted solution contains glucagon as hydrochloride 1 mg/mL (1 unit/mL) and lactose monohydrate (107 mg). GlucaGen is supplied at pH 2.5-3.5 and is soluble in water.

What are the possible side effects of glucagon (GlucaGen)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include nausea and vomiting, or rapid heartbeats.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at...

Read All Potential Side Effects and See Pictures of GlucaGen

What are the precautions when taking glucagon [rdna origin]) for injection (GlucaGen)?

Before using glucagon, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain adrenal problem (pheochromocytoma), tumor of the pancreas (insulinoma).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: adrenal gland problem (e.g., Addison's disease), frequent alcohol use, heart disease (coronary artery disease), not eating/poor eating habits, frequent low blood sugar.

Low blood sugar...

Read All Potential Precautions of GlucaGen


GlucaGen Consumer (continued)

SIDE EFFECTS: Nausea, vomiting, and fast heartbeat may occur. If these effects persist or worsen, tell your doctor promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these rare but very serious side effects occur: fast/pounding heartbeat.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using glucagon, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain adrenal problem (pheochromocytoma), tumor of the pancreas (insulinoma).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: adrenal gland problem (e.g., Addison's disease), frequent alcohol use, heart disease (coronary artery disease), not eating/poor eating habits, frequent low blood sugar.

Low blood sugar (hypoglycemia) is more likely if you drink large amounts of alcohol, do unusually heavy exercise, or do not consume enough calories from food. Symptoms include cold sweat, blurred vision, confusion, dizziness, drowsiness, shaking, fast heartbeat, headache, fainting, seizures, tingling of the hands/feet, and hunger. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor about the reaction immediately. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Though there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.


GlucaGen Patient Information Including Side Effects

Brand Names: GlucaGen

Generic Name: glucagon (Pronunciation: GLOO ka gon)

  • What is glucagon (GlucaGen)?
  • What are the possible side effects of glucagon (GlucaGen)?
  • What is the most important information I should know about glucagon (GlucaGen)?
  • What should I discuss with my health care provider before taking glucagon (GlucaGen)?
  • How should I use glucagon (GlucaGen)?
  • What happens if I miss a dose (GlucaGen)?
  • What happens if I overdose (GlucaGen)?
  • What should I avoid while taking glucagon (GlucaGen)?
  • What other drugs will affect glucagon (GlucaGen)?
  • Where can I get more information?

What is glucagon (GlucaGen)?

Glucagon is a hormone produced in the pancreas. It increases blood sugar levels.

Glucagon is used to treat insulin coma or insulin reaction resulting from severe hypoglycemia (low blood sugar).

Glucagon may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of glucagon (GlucaGen)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include nausea and vomiting, or rapid heartbeats.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about glucagon (GlucaGen)?

Familiarize yourself with the directions included in the glucagon product before you have to use it. This information handout is not intended to replace the specific directions provided with the product. If you did not receive specific directions with your glucagon product talk to your doctor or healthcare provider.

Make sure that your relatives and close friends know that if you become unconscious they should seek medical assistance. Glucagon may have been prescribed so that members of your household can give the injection if you become hypoglycemic and are unable to take sugar by mouth. If you are unconscious, glucagon can be given while awaiting medical assistance. Show your family members and others where you keep the kit and how to use it. They need to know how to use it before you need it. They can practice giving a shot by giving you your normal insulin shots. It is important that they practice. A person who has never given a shot probably will not be able to do it in an emergency.

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