Panhematin

DRUG DESCRIPTION

PANHEMATIN (hemin for injection) is an enzyme inhibitor derived from processed red blood cells. Hemin for injection was known previously as hematin. The term hematin has been used to describe the chemical reaction product of hemin and sodium carbonate solution. Hemin is an iron containing metalloporphyrin. Chemically hemin is represented as chloro [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato (2-)-N21,N22,N23,N24] iron. The structural formula for hemin is:

PANHEMATIN® (HEMIN) Structural Formula Illustration

PANHEMATIN (hemin) is a sterile, lyophilized powder suitable for intravenous administration after reconstitution. Each dispensing vial of PANHEMATIN contains the equivalent of 313 mg hemin, 215 mg sodium carbonate and 300 mg of sorbitol. The pH may have been adjusted with hydrochloric acid; the product contains no preservatives. When mixed as directed with Sterile Water for Injection, USP, each 43 mL provides the equivalent of approximately 301 mg hematin (7 mg/mL).

What are the possible side effects of hemin (Panhematin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using hemin and call your doctor at once if you have a serious side effect such as:

  • urinating less than usual or not at all;
  • swelling, weight gain, feeling short of breath;
  • fever;
  • easy bruising or bleeding; or
  • swelling, pain, or irritation around the IV needle.

This is not a complete list of side effects...

Read All Potential Side Effects and See Pictures of Panhematin »

What are the precautions when taking hemin (Panhematin)?

Before using hemin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

Though unlikely, it is possible for this medication to contain substances that could cause infections because it is made from human plasma. Notify your doctor immediately if you develop early signs of an infection such as a persistent sore throat or fever, yellowing eyes or skin, or dark urine.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not...

Read All Potential Precautions of Panhematin »


Panhematin Consumer (continued)

SIDE EFFECTS: Discoloration of the skin or pain, tenderness, or swelling along your veins may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: easy bruising or bleeding.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using hemin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

Though unlikely, it is possible for this medication to contain substances that could cause infections because it is made from human plasma. Notify your doctor immediately if you develop early signs of an infection such as a persistent sore throat or fever, yellowing eyes or skin, or dark urine.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.


Panhematin Patient Information Including Side Effects

Brand Names: Panhematin

Generic Name: hemin (Pronunciation: HEE min)

  • What is hemin (Panhematin)?
  • What are the possible side effects of hemin (Panhematin)?
  • What is the most important information I should know about hemin (Panhematin)?
  • What should I discuss with my health care provider before using hemin (Panhematin)?
  • How should I use hemin (Panhematin)?
  • What happens if I miss a dose (Panhematin)?
  • What happens if I overdose (Panhematin)?
  • What should I avoid while using hemin (Panhematin)?
  • What other drugs will affect hemin (Panhematin)?
  • Where can I get more information?

What is hemin (Panhematin)?

Hemin is an enzyme inhibitor that is made from red blood cells. It works by lowering the production of a certain enzyme in the body.

Hemin is used to treat the symptoms of occasional attacks of porphyria related to the menstrual cycle in women. Hemin helps control symptoms such as pain, increased heart rate or blood pressure, and changes in mental status.

Hemin should not be used to treat porphyria cutanea tarda.

Hemin is not a cure for porphyria. It will only control the symptoms of a porphyria episode.

Hemin may also be used for other purposes not listed in this medication guide.

What are the possible side effects of hemin (Panhematin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using hemin and call your doctor at once if you have a serious side effect such as:

  • urinating less than usual or not at all;
  • swelling, weight gain, feeling short of breath;
  • fever;
  • easy bruising or bleeding; or
  • swelling, pain, or irritation around the IV needle.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about hemin (Panhematin)?

Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Using too much hemin could be harmful to your kidneys. Follow the directions on your prescription label.

You should not use this medication if you are allergic to hemin.

Before using hemin, tell your doctor if you are allergic to latex rubber.

Also tell your doctor if you take birth control pills, hormone replacement therapy, a blood thinner, steroids, or a barbiturate sedative.

Hemin is made from human blood and may contain viruses and other infectious agents that can cause disease. Although donated human blood is screened, tested, and treated to reduce the risk of it containing anything that could cause disease, there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

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