Hismanal

(Generic versions may still be available.)

DRUG DESCRIPTION

Hismanal (astemizole) is a histamine H1-receptor antagonist available in scored white tablets for oral use. Each tablet contains 10 mg of astemizole, and as inactive ingredients: lactose, cornstarch, microcrystalline cellulose, pregelatinized starch, povidone K90, magnesium stearate, colloidal silicon dioxide, and sodium lauryl sulfate. Astemizole is chemically designated as 1-[(4-fluorophenyl) -methyl] -N-[1-[2-(4-methoxyphenyl) ethyl]-4 -piperidinyl]-1H-benzimidazol-2-amine, with a molecular weight of 458.58. The empirical formula is C28H31FN4O.

Astemizole is a white to slightly off-white powder; it is insoluble in water, slightly soluble in ethanol and soluble in chloroform and methanol.

What are the possible side effects of astemizole (Hismanal)?

If you experience any of the following serious side effects, stop taking astemizole and call your doctor immediately or seek emergency medical attention:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • an irregular heartbeat;
  • fainting; or
  • seizures.

Other, less serious side effects may be more likely to occur. Continue to take astemizole and talk to your doctor if you experience

  • drowsiness or...

Read All Potential Side Effects and See Pictures of Hismanal


Hismanal Patient Information Including Side Effects

Brand Names: Hismanal

Generic Name: astemizole (Pronunciation: a STEH mih zole)

  • What is astemizole (Hismanal)?
  • What are the possible side effects of astemizole (Hismanal)?
  • What is the most important information I should know about astemizole (Hismanal)?
  • Who should not take astemizole (Hismanal)?
  • How should I take astemizole (Hismanal)?
  • What happens if I miss a dose (Hismanal)?
  • What happens if I overdose (Hismanal)?
  • What should I avoid while taking astemizole (Hismanal)?
  • What other drugs will affect astemizole (Hismanal)?
  • Where can I get more information?

What is astemizole (Hismanal)?

Astemizole was withdrawn from the U.S. market in 1999.

Astemizole is an antihistamine. Antihistamines prevent sneezing, runny nose, itching and watering of the eyes, and other allergic symptoms.

Astemizole is used to treat allergies, hives (urticaria), and other allergic inflammatory conditions.

Astemizole may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of astemizole (Hismanal)?

If you experience any of the following serious side effects, stop taking astemizole and call your doctor immediately or seek emergency medical attention:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • an irregular heartbeat;
  • fainting; or
  • seizures.

Other, less serious side effects may be more likely to occur. Continue to take astemizole and talk to your doctor if you experience

  • drowsiness or dizziness;
  • headache;
  • nervousness;
  • nausea, diarrhea, or abdominal discomfort;
  • dry mouth; or
  • dry skin or itchiness.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What is the most important information I should know about astemizole (Hismanal)?

Astemizole was withdrawn from the U.S. market in 1999.

Do not take astemizole (Hismanal) with any of the following medicines: antifungal drugs such as ketoconazole (Nizoral) and itraconazole (Sporanox); antibiotics such as erythromycin (E.E.S., E-Mycin, Ery-Tab), clarithromycin (Biaxin), and troleandomycin (TAO); the malaria medicine quinine (Quinamm); or the medicine nefazodone (Serzone).

Take astemizole on an empty stomach, 1 hour before or 2 hours after eating food.

Do not take astemizole with grapefruit or grapefruit juice. Grapefruit products may increase amount of astemizole available in your body, which could lead to dangerous side effects.

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