Inversine

DRUG DESCRIPTION

INVERSINE® (Mecamylamine HCl) is a potent, oral antihypertension agent and ganglion blocker, and is a secondary amine. It is N,2,3,3-tetramethyl-bicyclo (2.2.1] heptan- 2 -amine hydrochloride. Its empirical formula is C11H21N • HCI and its structural formula is:

Inversine (Mecamylamine HCI) Structural Formula Illustration

It is a white, odorless, or practically odorless, crystalline powder, is highly stable, soluble in water and has a molecular weight of 203.75.

INVERSINE (mecamylamine) is supplied as tablets for oral use, each containing 2.5 mg mecamylamine HCI. Inactive ingredients are acacia, calcium phosphate, D&C Yellow 10, FD&C Yellow 6, lactose, magnesium stearate, starch, and talc.

What are the possible side effects of mecamylamine (Inversine)?

If you experience any of the following serious side effects, stop taking mecamylamine and seek emergency medical attention:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); or
  • abdominal pain, abdominal distention, or diarrhea.

Other, less serious side effects may be more likely to occur. Continue to take mecamylamine and talk to your doctor if you experience

  • nausea, vomiting, or constipation;
  • dry...

Read All Potential Side Effects and See Pictures of Inversine »

What are the precautions when taking mecamylamine (Inversine)?

Before taking mecamylamine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain eye problem (glaucoma), certain stomach condition (organic pyloric stenosis).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (such as chest pain, heart attack), blood flow problems especially to the brain/heart (such as stroke, TIA), kidney disease, bladder/urination problems (such as bladder...

Read All Potential Precautions of Inversine »


Inversine Consumer (continued)

SIDE EFFECTS: Drowsiness, dizziness, lightheadedness, tiredness, blurred vision, nausea, constipation, and dry mouth may occur as your body adjusts to the medication. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Hot weather, exercise, or alcohol may increase dizziness and lightheadedness. Fever, vomiting, diarrhea, bleeding, loss of salt, or heavy sweating may also increase dizziness. To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: fainting, fast/irregular heartbeat, difficulty urinating, decreased sexual ability/interest.

Tell your doctor immediately if any of these rare but serious side effects occur: shaking (tremor), uncontrolled movements of the face/hands/arms/legs.

If you develop frequent diarrhea with severe stomach/abdominal discomfort and/or bloating while taking this medication, seek immediate medical attention. This may be a sign of a very serious problem (paralytic ileus).

Seek immediate medical attention if any of these rare but serious side effects occur: chest pain, mental/mood changes (such as anxiety, confusion, depression), seizures.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking mecamylamine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain eye problem (glaucoma), certain stomach condition (organic pyloric stenosis).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (such as chest pain, heart attack), blood flow problems especially to the brain/heart (such as stroke, TIA), kidney disease, bladder/urination problems (such as bladder neck obstruction, urethral stricture), enlarged prostate (prostatic hypertrophy), salt-restricted diet.

Before having surgery, tell your doctor or dentist that you are taking this medication.

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Avoid alcoholic beverages.

Kidney function declines as you grow older. This medication is removed by the kidneys. Older adults may be more sensitive to its effects, especially dizziness.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.


Inversine Patient Information Including Side Effects

Brand Names: Inversine

Generic Name: mecamylamine (Pronunciation: meck a MILL a meen)

  • What is mecamylamine (Inversine)?
  • What are the possible side effects of mecamylamine (Inversine)?
  • What is the most important information I should know about mecamylamine (Inversine)?
  • Who should not take mecamylamine (Inversine)?
  • How should I take mecamylamine (Inversine)?
  • What happens if I miss a dose (Inversine)?
  • What happens if I overdose (Inversine)?
  • What should I avoid while taking this mecamylamine (Inversine)?
  • What other drugs will affect mecamylamine (Inversine)?
  • Where can I get more information?

What is mecamylamine (Inversine)?

Mecamylamine is used to treat moderate to severe hypertension (high blood pressure). Because of its many side effects, mecamylamine is not commonly used.

Mecamylamine may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of mecamylamine (Inversine)?

If you experience any of the following serious side effects, stop taking mecamylamine and seek emergency medical attention:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); or
  • abdominal pain, abdominal distention, or diarrhea.

Other, less serious side effects may be more likely to occur. Continue to take mecamylamine and talk to your doctor if you experience

  • nausea, vomiting, or constipation;
  • dry mouth;
  • decreased appetite;
  • dizziness and fainting;
  • drowsiness or weakness;
  • dilated (large) pupils and blurred vision; or
  • difficulty urinating.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about mecamylamine (Inversine)?

Use caution when driving, operating machinery, or performing other hazardous activities. Mecamylamine may cause dizziness. If you experience dizziness, avoid these activities.

If you experience dizziness, rise slowly from a sitting or lying position to avoid falling.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking mecamylamine.

Take mecamylamine every day at the same time, usually after meals.

Call your doctor if you experience tremor, abdominal pain, abdominal distention, or diarrhea.

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