Lioresal Intrathecal

DRUG DESCRIPTION

LIORESAL INTRATHECAL (baclofen injection) is a muscle relaxant and antispastic. Its chemical name is 4- amino- 3-( 4- chlorophenyl) butanoic acid, and its structural formula is:

Lioresal Intrathecal (Baclofen) Structural Formula Illustration

Baclofen is a white to off- white, odorless or practically odorless crystalline powder, with a molecular weight of 213.66. It is slightly soluble in water, very slightly soluble in methanol, and insoluble in chloroform.

LIORESAL INTRATHECAL (baclofen injection) is a sterile, pyrogen-free, isotonic solution free of antioxidants, preservatives or other potentially neurotoxic additives indicated only for intrathecal administration. The drug is stable in solution at 37 C and compatible with CSF. Each milliliter of LIORESAL INTRATHECAL contains baclofen U. S. P. 50 mcg, 500 mcg or 2000 mcg and sodium chloride 9 mg in Water for Injection; pH range is 5.0 - 7.0. Each ampule is intended for SINGLE USE ONLY. Discard any unused portion. DO NOT AUTOCLAVE.

What are the possible side effects of baclofen (Lioresal)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • seizure (convulsions);
  • confusion, hallucinations; or
  • an uneven heartbeat.

Less serious side effects may include:

  • drowsiness, dizziness, weakness, tired feeling;
  • headache;
  • sleep problems (insomnia);
  • nausea,...

Read All Potential Side Effects and See Pictures of Lioresal Intrathecal


Lioresal Intrathecal Patient Information Including Side Effects

Brand Names: Lioresal

Generic Name: baclofen (Pronunciation: BAK loe fen)

  • What is baclofen (Lioresal Intrathecal)?
  • What are the possible side effects of baclofen (Lioresal Intrathecal)?
  • What is the most important information I should know about baclofen (Lioresal Intrathecal)?
  • What should I discuss with my healthcare provider before taking baclofen (Lioresal Intrathecal)?
  • How should I take baclofen (Lioresal Intrathecal)?
  • What happens if I miss a dose (Lioresal Intrathecal)?
  • What happens if I overdose (Lioresal Intrathecal)?
  • What should I avoid while taking baclofen (Lioresal Intrathecal)?
  • What other drugs will affect baclofen (Lioresal Intrathecal)?
  • Where can I get more information?

What is baclofen (Lioresal Intrathecal)?

Baclofen is a muscle relaxer and an antispastic agent.

Baclofen is used to treat muscle symptoms caused by multiple sclerosis, including spasm, pain, and stiffness.

Baclofen may also be used for other purposes not listed in this medication guide.

What are the possible side effects of baclofen (Lioresal Intrathecal)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • seizure (convulsions);
  • confusion, hallucinations; or
  • an uneven heartbeat.

Less serious side effects may include:

  • drowsiness, dizziness, weakness, tired feeling;
  • headache;
  • sleep problems (insomnia);
  • nausea, constipation; or
  • urinating more often than usual.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about baclofen (Lioresal Intrathecal)?

Baclofen can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid drinking alcohol. It can increase some of the side effects of baclofen.

Do not use baclofen at a time when muscle tone is needed to assure safe balance and movement for certain activities. In some situations, it may endanger your physical safety to be in a state of reduced muscle tone.

You may have withdrawal symptoms such as seizures or hallucinations, when you stop using baclofen after using it over a long period of time. Do not stop using this medication suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.

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