Lanoxin Injection

DRUG DESCRIPTION

LANOXIN (digoxin) is one of the cardiac (or digitalis) glycosides, a closely related group of drugs having in common specific effects on the myocardium. These drugs are found in a number of plants. Digoxin is extracted from the leaves of Digitalis lanata. The term “digitalis” is used to designate the whole group of glycosides. The glycosides are composed of 2 portions: a sugar and a cardenolide (hence “glycosides”).

Digoxin is described chemically as (3?,5?,12?)-3-[(O-2,6-dideoxy-?-D-ribo-hexopyranosyl (1?4)-O-2,6-dideoxy-?-D-ribo-hexopyranosyl-(1?4)-2,6-dideoxy-?-D-ribo hexopyranosyl)oxy]-12,14-dihydroxy-card-20(22)-enolide. Its molecular formula is C41H64O14, its molecular weight is 780.95, and its structural formula is:

LANOXIN® (digoxin)  Structural Formula Illustration

Digoxin exists as odorless white crystals that melt with decomposition above 230°C. The drug is practically insoluble in water and in ether; slightly soluble in diluted (50%) alcohol and in chloroform; and freely soluble in pyridine.

LANOXIN Injection is a sterile solution of digoxin for intravenous or intramuscular injection. The vehicle contains 40% propylene glycol and 10% alcohol. The injection is buffered to a pH of 6.8 to 7.2 with 0.17% dibasic sodium phosphate and 0.08% anhydrous citric acid. Each 2-mL ampul contains 500 mcg (0.5 mg) digoxin (250 mcg [0.25 mg] per mL). Dilution is not required.

What are the precautions when taking digoxin injection (Lanoxin Injection)?

Before taking digoxin, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as digitoxin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, thyroid problems (underactive or overactive).

The balance of certain natural minerals in your blood (calcium, magnesium, potassium) can affect how this drug works in your body. Certain drugs such as "water pills" (diuretics) may affect the normal balance of these minerals. Tell your doctor or pharmacist if you are taking a "water pill" or if you have a history of...

Read All Potential Precautions of Lanoxin Injection »


Lanoxin Injection Consumer (continued)

SIDE EFFECTS: Nausea, vomiting, headache, loss of appetite, and diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: weakness, mental/mood changes, vision changes (such as blurred or yellow/green vision), enlarged/tender breasts in men.

Though this medication is used to treat a certain type of irregular heartbeat, it may infrequently cause other types of irregular heartbeats. Tell your doctor immediately if you notice any unusually fast/slow/irregular heartbeat.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking digoxin, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as digitoxin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, thyroid problems (underactive or overactive).

The balance of certain natural minerals in your blood (calcium, magnesium, potassium) can affect how this drug works in your body. Certain drugs such as "water pills" (diuretics) may affect the normal balance of these minerals. Tell your doctor or pharmacist if you are taking a "water pill" or if you have a history of mineral imbalance. Ask your doctor or pharmacist whether you should take a nutritional supplement or follow a special diet.

Before having surgery or certain procedures on your heart (such as electrical cardioversion), tell your doctor or dentist that you are using this medication.

Infants and children may be more sensitive to the effects of this drug, especially the effects on the heartbeat.

Tell your doctor if you are pregnant before using this medication.

Digoxin passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.



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