Lucentis

DRUG DESCRIPTION

LUCENTIS® (ranibizumab injection) is a recombinant humanized IgGl kappa isotype monoclonal antibody fragment designed for intraocular use. Ranibizumab binds to and inhibits the biologic activity of human vascular endothelial growth factor A (VEGF-A). Ranibizumab has a molecular weight of approximately 48 kilodaltons and is produced by an E. coli expression system in a nutrient medium containing the antibiotic tetracycline. Tetracycline is not detectable in the final product.

LUCENTIS (ranibizumab injection) is a sterile, colorless to pale yellow solution in a single-use glass vial. LUCENTIS (ranibizumab injection) is supplied as a preservative-free, sterile solution in a single-use glass vial designed to deliver 0.05 mL of 10 mg/mL LUCENTIS (ranibizumab injection) aqueous solution with 10 mM histidine HC1, 10% a,a-trehalose dihydrate, 0.01% polysorbate 20, pH 5.5.

What are the possible side effects of ranibizumab (Lucentis)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • vision changes;
  • eye pain, redness, or irritation;
  • discharge or bleeding from the eye;
  • increased eye sensitivity to light;
  • swelling around your eye;
  • seeing "stars" or flashes of light, especially in your peripheral (side) vision;
  • ...

Read All Potential Side Effects and See Pictures of Lucentis »

What are the precautions when taking ranibizumab injection (Lucentis)?

Before receiving ranibizumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have a certain medical condition. Before using this medicine, consult your doctor or pharmacist if you have: a current eye infection.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. However, this medication is unlikely to pass into breast milk. Consult your doctor before...

Read All Potential Precautions of Lucentis »


Lucentis Consumer (continued)

SIDE EFFECTS: Mild discomfort and increased tears may occur in the affected eye(s). If either of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may infrequently increase your risk for developing a certain serious eye condition (endophthalmitis), especially during the first week after receiving a dose. Tell your doctor immediately if you notice any of these symptoms in the affected eye(s): pain, redness, sensitivity to light, sudden change in vision.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before receiving ranibizumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have a certain medical condition. Before using this medicine, consult your doctor or pharmacist if you have: a current eye infection.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. However, this medication is unlikely to pass into breast milk. Consult your doctor before breast-feeding.


Lucentis Patient Information Including Side Effects

Brand Names: Lucentis

Generic Name: ranibizumab (ophthalmic) (Pronunciation: ra NIB i ZUE mab)

  • What is ranibizumab (Lucentis)?
  • What are the possible side effects of ranibizumab (Lucentis)?
  • What is the most important information I should know about ranibizumab (Lucentis)?
  • What should I discuss with my health care provider before receiving ranibizumab (Lucentis)?
  • How is ranibizumab used (Lucentis)?
  • What happens if I miss a dose (Lucentis)?
  • What happens if I overdose (Lucentis)?
  • What should I avoid while receiving ranibizumab (Lucentis)?
  • What other drugs will affect ranibizumab (Lucentis)?
  • Where can I get more information?

What is ranibizumab (Lucentis)?

Ranibizumab is made from a human antibody fragment. It works by keeping new blood vessels from forming under the retina (a sensory membrane that lines the inside of the eye). In people with a certain type of eye disease, new blood vessels grow under the retina where they leak blood and fluid. This is known as the "wet form" of macular degeneration.

Ranibizumab is used to treat the wet form of age-related macular degeneration.

Ranibizumab may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of ranibizumab (Lucentis)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • vision changes;
  • eye pain, redness, or irritation;
  • discharge or bleeding from the eye;
  • increased eye sensitivity to light;
  • swelling around your eye;
  • seeing "stars" or flashes of light, especially in your peripheral (side) vision;
  • pain or burning when you urinate.
  • sudden numbness or weakness, especially on one side of the body; or
  • sudden headache, confusion, problems with vision, speech, or balance.

Other less serious side effects are more likely to occur, such as:

  • itchy or watery eyes;
  • dry eyes;
  • blurred vision;
  • runny or stuffy nose, cough, sore throat; or
  • joint or muscle pain.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about ranibizumab (Lucentis)?

Do not receive this medication if you are allergic to ranibizumab, or if you have an infection in or around your eye. Before you receive this medication, tell your doctor if you have glaucoma.

Ranibizumab is given as an injection into your eye. Your doctor will use a medicine to numb your eye before giving you the injection. You will receive this injection in your doctor's office or other clinic setting.

Ranibizumab is usually given once a month. After you have received the first 4 injections, your doctor may change your injection schedule to once every 3 months. Follow your doctor's instructions.

Call your doctor at once if you have any of these serious side effects: vision changes, eye pain or redness, discharge or bleeding from your eye, increased eye sensitivity to light, swelling around the eye, or seeing flashes of light.

Call your doctor for instructions if you miss an appointment to receive your ranibizumab injection.

Related Drug Centers
  • Lucentis


Related Drugs Index: