Lopid

DRUG DESCRIPTION

LOPID® (gemfibrozil tablets, USP) is a lipid regulating agent. It is available as tablets for oral administration. Each tablet contains 600 mg gemfibrozil. Each tablet also contains calcium stearate, NF; candelilla wax, FCC; microcrystalline cellulose, NF; hydroxypropyl cellulose, NF; hypromellose, USP; methylparaben, NF; Opaspray white; polyethylene glycol, NF; polysorbate 80, NF; propylparaben, NF; colloidal silicon dioxide, NF; pregelatinized starch, NF. The chemical name is 5-(2,5-dimethylphenoxy)2,2-dimethylpentanoic acid, with the following structural formula:

LOPID®
(Gemfibrozil) Structural Formula Illustration

The empirical formula is C15H22O3 and the molecular weight is 250.35; the solubility in water and acid is 0.0019% and in dilute base it is greater than 1%. The melting point is 58° –61°C. Gemfibrozil is a white solid which is stable under ordinary conditions.

What are the possible side effects of gemfibrozil (Lopid)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • sharp pain in your upper stomach (especially after eating);
  • jaundice (yellowing of your skin or eyes);
  • blurred vision, eye pain, or seeing halos around lights; or
  • pain or burning when you urinate.

Less serious side effects may include:

    ...

Read All Potential Side Effects and See Pictures of Lopid »

What are the precautions when taking gemfibrozil (Lopid)?

Before taking gemfibrozil, tell your doctor or pharmacist if you are allergic to it; or to other "fibrates" (such as fenofibrate); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease (such as biliary cirrhosis), gallbladder disease, kidney disease, alcohol use.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication is not recommended for use during pregnancy. Consult your doctor for more details.

It is...

Read All Potential Precautions of Lopid »


Lopid Consumer (continued)

SIDE EFFECTS: Stomach upset, stomach/abdominal pain, or unusual taste may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may infrequently cause gallstones and liver problems. If you notice any of the following unlikely but serious side effects, tell your doctor immediately: severe stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine.

This drug may infrequently cause muscle problems (which can rarely lead to a very serious condition called rhabdomyolysis). Tell your doctor immediately if you develop any of these symptoms: muscle pain/tenderness/weakness (especially with fever or unusual tiredness), change in the amount of urine.

Tell your doctor immediately if any of these rare but serious side effects occur: signs of infection (such as fever, persistent sore throat), easy bruising/bleeding, unusual tiredness, irregular heartbeat, numbness/tingling of arms/legs.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking gemfibrozil, tell your doctor or pharmacist if you are allergic to it; or to other "fibrates" (such as fenofibrate); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease (such as biliary cirrhosis), gallbladder disease, kidney disease, alcohol use.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication is not recommended for use during pregnancy. Consult your doctor for more details.

It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.


Lopid Patient Information Including Side Effects

Brand Names: Lopid

Generic Name: gemfibrozil (Pronunciation: jem FYE broe zil)

  • What is gemfibrozil (Lopid)?
  • What are the possible side effects of gemfibrozil (Lopid)?
  • What is the most important information I should know about gemfibrozil (Lopid)?
  • What should I discuss with my healthcare provider before taking gemfibrozil (Lopid)?
  • How should I take gemfibrozil (Lopid)?
  • What happens if I miss a dose (Lopid)?
  • What happens if I overdose (Lopid)?
  • What should I avoid while taking gemfibrozil (Lopid)?
  • What other drugs will affect gemfibrozil (Lopid)?
  • Where can I get more information?

What is gemfibrozil (Lopid)?

Gemfibrozil helps reduce cholesterol and triglycerides (fatty acids) in the blood. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries).

Gemfibrozil is used to treat very high cholesterol and triglyceride levels in people with pancreatitis.

Gemfibrozil is also used to lower the risk of stroke, heart attack, or other heart complications in people with high cholesterol and triglycerides who have not been helped by other treatment methods.

Gemfibrozil may also be used for other purposes not listed in this medication guide.

What are the possible side effects of gemfibrozil (Lopid)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • sharp pain in your upper stomach (especially after eating);
  • jaundice (yellowing of your skin or eyes);
  • blurred vision, eye pain, or seeing halos around lights; or
  • pain or burning when you urinate.

Less serious side effects may include:

  • heartburn, upset stomach;
  • nausea, vomiting, diarrhea, constipation, stomach pain;
  • dizziness, spinning sensation;
  • drowsiness, tired feeling;
  • unusual or unpleasant taste in your mouth;
  • cough or cold symptoms;
  • numbness or tingly feeling;
  • joint or muscle pain;
  • mild skin rash; or
  • blurred vision.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about gemfibrozil (Lopid)?

You should not use this medication if you are allergic to gemfibrozil, if you are also taking repaglinide (Prandin), or if you have gallbladder disease, liver disease, or severe kidney disease.

Gemfibrozil is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Avoid eating foods that are high in fat or cholesterol. Gemfibrozil will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

To be sure this medication is helping your condition, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled appointments.

Call your doctor at once if you have a serious side effect such as sharp pain in your upper stomach (especially after eating), jaundice (yellowing of your skin or eyes), blurred vision, eye pain, or seeing halos around lights, or pain or burning when you urinate.

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