Levoleucovorin

DRUG DESCRIPTION

levoleucovorin is the levo isomeric form of racemic d,l-leucovorin, present as the calcium salt. levoleucovorin is the pharmacologically active isomer of leucovorin [(6-S)-leucovorin].

levoleucovorin for injection contains levoleucovorin calcium, which is one of several active, chemically reduced derivatives of folic acid. It is useful as antidote to the inhibition of dihydrofolate reductase by methotrexate. This compound has the chemical designation calcium (6S)-N-{4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl] amino]benzoyl-L-glutamate pentahydrate. The molecular weight is 601.6 and the structural formula is:

levoleucovorin (injection) Structural Formula Illustration

Its molecular formula is: C20H21CaN7O7 5 H2O.

levoleucovorin for injection is supplied as a sterile lyophilized powder consisting of 64 mg levoleucovorin calcium pentahydrate (equivalent to 50 mg levoleucovorin) and 50 mg mannitol per 50 mg vial.

Sodium hydroxide and/or hydrocholoric acid are used to adjust the pH during manufacture. It is intended for intravenous administration after reconstitution with 5.3 mL of sterile 0.9% Sodium Chloride Injection, USP [See DOSAGE AND ADMINISTRATION]

What are the possible side effects of levoleucovorin (Fusilev)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • white patches or sores inside your mouth or on your lips;
  • urinating more or less than usual;
  • numbness or tingling;
  • fever, chills;
  • confusion; or
  • trouble breathing.

Less serious side effects may include:

    ...

Read All Potential Side Effects and See Pictures of Levoleucovorin


Levoleucovorin Patient Information Including Side Effects

Brand Names: Fusilev

Generic Name: levoleucovorin (Pronunciation: LEE voe LOO koe VOE rin)

  • What is levoleucovorin (Levoleucovorin)?
  • What are the possible side effects of levoleucovorin (Levoleucovorin)?
  • What is the most important information I should know about levoleucovorin (Levoleucovorin)?
  • What should I discuss with my healthcare provider before I receive levoleucovorin (Levoleucovorin)?
  • How is levoleucovorin given (Levoleucovorin)?
  • What happens if I miss a dose (Levoleucovorin)?
  • What happens if I overdose (Levoleucovorin)?
  • What should I avoid while receiving levoleucovorin (Levoleucovorin)?
  • What other drugs will affect levoleucovorin (Levoleucovorin)?
  • Where can I get more information?

What is levoleucovorin (Levoleucovorin)?

Levoleucovorin is used to treat or prevent toxic effects of methotrexate in people who have received methotrexate to treat bone cancer.

Levoleucovorin is also used to treat or prevent toxic effects of methotrexate in people whose bodies do not eliminate methotrexate properly after the drug is metabolized.

Levoleucovorin may also be used to treat toxic effects of an accidental overdose of methotrexate.

Levoleucovorin should not be used to treat anemia that is caused by a lack of vitamin B12.

Levoleucovorin may also be used for other purposes not listed in this medication guide.

What are the possible side effects of levoleucovorin (Levoleucovorin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • white patches or sores inside your mouth or on your lips;
  • urinating more or less than usual;
  • numbness or tingling;
  • fever, chills;
  • confusion; or
  • trouble breathing.

Less serious side effects may include:

  • nausea, vomiting, diarrhea;
  • stomach pain, upset stomach;
  • mild skin rash; or
  • white patches or sores inside your mouth or on your lips.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about levoleucovorin (Levoleucovorin)?

You should not receive this medication if you are allergic to levoleucovorin or to folic acid or folinic acid.

If possible, before you receive levoleucovorin, tell your doctor if you have kidney or liver disease, or if you are dehydrated.

Tell your doctor if you are taking sulfa drugs, seizure medication, a cancer medication called fluorouracil (5FU), or a multivitamin or mineral supplement than contains folic acid.

In an emergency situation, it may not be possible before you are treated to tell your caregivers about any health conditions you have or if you are pregnant or breast-feeding. However, make sure any doctor caring for you afterward knows that you have received this medication.

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