Lactulose Solution

DRUG DESCRIPTION

Lactulose is a synthetic disaccharide in solution form for oral or rectal administration. Each 15 mL of Lactulose Solution USP contains 10 g lactulose (and less than 1.6 g galactose, less than 1.2 g lactose, and 0.1 g or less of fructose). It also contains D&C Yellow No. 10, FD & C Yellow No. 6 and Purified Water.

Lactulose is a colonic acidifier for treatment and prevention of portal-systemic encephalopathy.

The chemical name for lactulose is 4-O-?-D-galactopyranosyl-D-fructofuranose. It has the following structural formula:

Lactulose Structural Formula Illustration

The molecular weight is 342.30. It is freely soluble in water.

What are the possible side effects of lactulose (Enulose, Generlac, Kristalose)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using lactulose and call your doctor at once if you have severe or ongoing diarrhea.

Less serious side effects may include:

  • bloating, gas;
  • stomach pain;
  • diarrhea; or
  • nausea, vomiting.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual...

Read All Potential Side Effects and See Pictures of Lactulose Solution

What are the precautions when taking lactulose solution (Lactulose Solution)?

Before taking lactulose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: a low galactose diet (e.g., a diet that includes few or no milk products), certain other bowel problem (bowel obstruction).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes.

The elderly may be at a greater risk for loss of blood minerals (e.g., potassium, sodium) while using this drug, especially if they...

Read All Potential Precautions of Lactulose Solution


Lactulose Solution Consumer (continued)

SIDE EFFECTS: Gas, bloating, burping, stomach rumbling/pain, nausea, and cramps may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: diarrhea, vomiting, muscle cramps/weakness, irregular heartbeat, mental/mood changes, seizures.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking lactulose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: a low galactose diet (e.g., a diet that includes few or no milk products), certain other bowel problem (bowel obstruction).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes.

The elderly may be at a greater risk for loss of blood minerals (e.g., potassium, sodium) while using this drug, especially if they are using it for an extended time.

Do not take any other laxative medications while taking this drug. Frequent use or overuse of laxatives can cause a severe loss of body water (dehydration). This is especially likely to occur in children or the elderly. Contact your doctor immediately if you develop any of the following symptoms of dehydration: muscle weakness, muscle cramps, dizziness.

Before having surgery or other procedures (e.g., electrocautery), tell your doctor or surgeon that you are using this medication.

This medication contains different sugars. If you have diabetes, this medication may affect your blood glucose levels. Monitor your blood glucose regularly, and share the results with your doctor. Your anti-diabetic medications or diet may need to be adjusted.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.


Lactulose Solution Patient Information Including Side Effects

Brand Names: Enulose, Generlac, Kristalose

Generic Name: lactulose (Pronunciation: LAK too lose)

  • What is lactulose (Lactulose Solution)?
  • What are the possible side effects of lactulose (Lactulose Solution)?
  • What is the most important information I should know about lactulose (Lactulose Solution)?
  • What should I discuss with my healthcare provider before taking lactulose (Lactulose Solution)?
  • How should I take lactulose (Lactulose Solution)?
  • What happens if I miss a dose (Lactulose Solution)?
  • What happens if I overdose (Lactulose Solution)?
  • What should I avoid while taking lactulose (Lactulose Solution)?
  • What other drugs will affect lactulose (Lactulose Solution)?
  • Where can I get more information?

What is lactulose (Lactulose Solution)?

Lactulose is a type of sugar. It is broken down in the large intestine into mild acids that draw water into the colon, which helps soften the stools.

Lactulose is used to treat chronic constipation.

Lactulose may also be used for other purposes not listed in this medication guide.

What are the possible side effects of lactulose (Lactulose Solution)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using lactulose and call your doctor at once if you have severe or ongoing diarrhea.

Less serious side effects may include:

  • bloating, gas;
  • stomach pain;
  • diarrhea; or
  • nausea, vomiting.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about lactulose (Lactulose Solution)?

You should not use this medication if you are on a special diet low in galactose (milk sugar).

Before taking lactulose, tell your doctor if you have diabetes or if you need to have any type of intestinal test using a scope (such as a colonoscopy).

It may take up to 48 hours before you have a bowel movement after taking lactulose.

Stop using lactulose and call your doctor at once if you have severe or ongoing diarrhea.

The liquid form of lactulose may become slightly darken in color, but this is a harmless effect. However, do not use the medicine if it becomes very dark, or if it gets thicker or thinner in texture.

If you use lactulose over a long period of time, your doctor may want you to have occasional blood tests. Do not miss any scheduled appointments.

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