Quixin

DRUG DESCRIPTION

QUIXIN® (levofloxacin ophthalmic solution) 0.5% is a sterile topical ophthalmic solution. Levofloxacin is a fluoroquinolone antibacterial active against a broad spectrum of Gram-positive and Gram-negative ocular pathogens. Levofloxacin is the pure (-)-(S)-enantiomer of the racemic drug substance, ofloxacin. It is more soluble in water at neutral pH than ofloxacin.

Structural Formula

QUIXIN® (levofloxacin) Structural Formula Illustration

Levofloxacin hemihydrate
C18H20FN3O4•?H2O     Mol Weight 370.38

Chemical Name:

(-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4 benzoxazine-6-carboxylic acid hemihydrate.

Levofloxacin (hemihydrate) is a yellowish-white crystalline powder.

Each mL of QUIXIN® contains 5.12 mg of levofloxacin hemihydrate equivalent to 5 mg levofloxacin.

Contains:

Active: Levofloxacin 0.5% (5 mg/mL); Preservative: benzalkonium chloride 0.005%; Inactives: sodium chloride and water. May also contain hydrochloric acid and/or sodium hydroxide to adjust pH.

QUIXIN® (levofloxacin ophthalmic solution 0.5%) solution is isotonic and formulated at pH 6.5 with an osmolality of approximately 300 mOsm/kg. Levofloxacin is a fluorinated 4-quinolone containing a six-member (pyridobenzoxazine) ring from positions 1 to 8 of the basic ring structure.

What are the possible side effects of levofloxacin ophthalmic (Quixin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • drainage or crusting of your eye;
  • severe eye irritation after using the eye drops;
  • feeling like there is something in your eye;
  • vision problems, increased light sensitivity;
  • eye redness or swelling; or
  • fever, or any signs of a new...

Read All Potential Side Effects and See Pictures of Quixin »

What are the precautions when taking levofloxacin ophthalmic solution 0.5% (Quixin)?

Before using levofloxacin, tell your doctor or pharmacist if you are allergic to it; or to other quinolone antibiotics (e.g., ciprofloxacin, norfloxacin); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems.

After you apply this drug, your vision may become temporarily blurred or unstable. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

During pregnancy, this medication should be used only...

Read All Potential Precautions of Quixin »


Quixin Consumer (continued)

SIDE EFFECTS: Temporary blurred or decreased vision, temporary stinging/burning/pain in the eyes, feeling as if something is in the eye, sensitivity of the eyes to light, fever, headache, or sore throat may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat/eye/eyelid), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using levofloxacin, tell your doctor or pharmacist if you are allergic to it; or to other quinolone antibiotics (e.g., ciprofloxacin, norfloxacin); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems.

After you apply this drug, your vision may become temporarily blurred or unstable. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

Based on information from related drugs, this medication may pass into breast milk. Consult your doctor before breast-feeding.


Quixin Patient Information Including Side Effects

Brand Names: Quixin

Generic Name: levofloxacin ophthalmic (Pronunciation: leev oh FLOX a sin off THAL mik)

  • What is levofloxacin ophthalmic (Quixin)?
  • What are the possible side effects of levofloxacin ophthalmic (Quixin)?
  • What is the most important information I should know about levofloxacin ophthalmic (Quixin)?
  • What should I discuss with my healthcare provider before using levofloxacin ophthalmic (Quixin)?
  • How should I use levofloxacin ophthalmic (Quixin)?
  • What happens if I miss a dose (Quixin)?
  • What happens if I overdose (Quixin)?
  • What should I avoid while using levofloxacin ophthalmic (Quixin)?
  • What other drugs will affect levofloxacin ophthalmic (Quixin)?
  • Where can I get more information?

What is levofloxacin ophthalmic (Quixin)?

Levofloxacin is in a group of antibiotics called fluoroquinolones (flor-o-KWIN-o-lones). Levofloxacin fights bacteria in the body.

Levofloxacin ophthalmic is used to treat bacterial infections of the eyes.

Levofloxacin ophthalmic may also be used for other purposes not listed in this medication guide.

What are the possible side effects of levofloxacin ophthalmic (Quixin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • drainage or crusting of your eye;
  • severe eye irritation after using the eye drops;
  • feeling like there is something in your eye;
  • vision problems, increased light sensitivity;
  • eye redness or swelling; or
  • fever, or any signs of a new infection.

Less serious side effects may include:

  • dry or itchy eyes;
  • headache;
  • sore throat; or
  • mild eye pain, burning, or discomfort.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about levofloxacin ophthalmic (Quixin)?

You should not use this medication if you are allergic to levofloxacin or a similar antibiotic such as ciprofloxacin (Cipro), ofloxacin (Floxin), norfloxacin (Noroxin), levofloxacin (Levaquin), lomefloxacin (Maxaquin), and others.

Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Serious side effects of levofloxacin ophthalmic may include eye drainage or crusting, severe eye irritation, feeling like there is something in your eye, vision problems, increased light sensitivity, eye redness or swelling, or any signs of new infection.

Keep using this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared.

Do not use this medication while you are wearing contact lenses. This medication may contain a preservative that can be absorbed by soft contact lenses. Wait at least 15 minutes after using levofloxacin ophthalmic before putting your contact lenses in.

You should not wear contact lenses while you still have active symptoms of the eye infection you are treating.

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