Xalatan

DRUG DESCRIPTION

Latanoprost is a prostaglandin F2? analogue. Its chemical name is isopropyl-(Z)-7[(lR,2R,3R,5S)3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoate. Its molecular formula is C26H40O5 and its chemical structure is:

Xalatan® 
  (latanoprost) Structural Formula Illustration

Latanoprost is a colorless to slightly yellow oil that is very soluble in acetonitrile and freely soluble in acetone, ethanol, ethyl acetate, isopropanol, methanol and octanol. It is practically insoluble in water.

XALATAN Sterile Ophthalmic Solution (latanoprost ophthalmic solution) is supplied as a sterile, isotonic, buffered aqueous solution of latanoprost with a pH of approximately 6.7 and an osmolality of approximately 267 mOsmol/kg. Each mL of XALATAN contains 50 micrograms of latanoprost. Benzalkonium chloride, 0.02% is added as a preservative. The inactive ingredients are: sodium chloride, sodium dihydrogen phosphate monohydrate, disodium hydrogen phosphate anhydrous and water for injection. One drop contains approximately 1.5 µg of latanoprost.

What are the possible side effects of latanoprost ophthalmic (Xalatan)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using latanoprost ophthalmic and call your doctor at once if you have any of these serious side effects:

  • redness, swelling, itching, or pain in or around your eye;
  • oozing or discharge from your eye;
  • increased sensitivity to light;
  • vision changes; or
  • chest pain.

Less serious side effects may...

Read All Potential Side Effects and See Pictures of Xalatan »

What are the precautions when taking latanoprost ophthalmic (Xalatan)?

Before using latanoprost, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: an active swelling process within the eye (e.g., iritis, uveitis).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems (e.g., macular edema, history of iritis/uveitis, lens extraction/aphakia), contact lens use.

If you develop an eye infection or...

Read All Potential Precautions of Xalatan »


Xalatan Consumer (continued)

SIDE EFFECTS: Blurred vision, burning/stinging/itching/redness of the eye, feeling as if something is in the eye, changes in eyelash number/color/length/thickness, eyelid skin darkening, dry eye, lid crusting/discomfort, increased sensitivity to light, flu-like symptoms, or muscle/joint pain may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

This medication may slowly (over months to years) cause brown discoloration of the colored portion of the eye (iris). If you are using latanoprost in only one eye, only that iris may change color. This color change may be permanent but the long-term effects are uncertain. Notify your doctor if this occurs and schedule regular eye exams to monitor it.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: eye pain, suspected eye infection (unusual redness or swelling of eyes), chest pain.

Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: rapid vision changes (e.g., loss of vision).

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, severe itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using latanoprost, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: an active swelling process within the eye (e.g., iritis, uveitis).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems (e.g., macular edema, history of iritis/uveitis, lens extraction/aphakia), contact lens use.

If you develop an eye infection or injury, or have eye surgery, check with your doctor about the continued use of your current bottle of latanoprost. You may be advised to start using a new bottle.

Your vision may be temporarily blurred or unstable after applying this drug. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.


Xalatan Patient Information Including Side Effects

Brand Names: Xalatan

Generic Name: latanoprost ophthalmic (Pronunciation: la TAN oh prost)

  • What is latanoprost ophthalmic (Xalatan)?
  • What are the possible side effects of latanoprost ophthalmic (Xalatan)?
  • What is the most important information I should know about latanoprost ophthalmic (Xalatan)?
  • What should I discuss with my health care provider before using latanoprost ophthalmic (Xalatan)?
  • How should I use latanoprost ophthalmic (Xalatan)?
  • What happens if I miss a dose (Xalatan)?
  • What happens if I overdose (Xalatan)?
  • What should I avoid while using latanoprost ophthalmic (Xalatan)?
  • What other drugs will affect latanoprost ophthalmic (Xalatan)?
  • Where can I get more information?

What is latanoprost ophthalmic (Xalatan)?

Latanoprost reduces pressure in the eye by increasing the amount of fluid that drains from the eye.

Latanoprost ophthalmic (for the eyes) is used to treat certain types of glaucoma and other causes of high pressure inside the eye.

Latanoprost ophthalmic may also be used for other purposes not listed in this medication guide.

What are the possible side effects of latanoprost ophthalmic (Xalatan)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using latanoprost ophthalmic and call your doctor at once if you have any of these serious side effects:

  • redness, swelling, itching, or pain in or around your eye;
  • oozing or discharge from your eye;
  • increased sensitivity to light;
  • vision changes; or
  • chest pain.

Less serious side effects may include:

  • cold symptoms such as stuffy nose, sneezing, sore throat;
  • headache, dizziness;
  • mild eye discomfort;
  • blurred vision;
  • feeling like something is in your eye;
  • dry or watery eyes; or
  • stinging or burning of the eyes after using the drops.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about latanoprost ophthalmic (Xalatan)?

Do not use this medication while you are wearing contact lenses. This medication may contain a preservative that can be absorbed by soft contact lenses. Wait at least 15 minutes after using latanoprost before putting your contact lenses in.

Latanoprost ophthalmic may cause a gradual change in the color of your eyes or eyelids and lashes, as well as increased growth or thickness of your eyelashes. These color changes, usually an increase in brown pigment, occur slowly and you may not notice them for months or years. Color changes may be permanent even after your treatment ends, and may occur only in the eye being treated. This could result in a cosmetic difference in eye or eyelash color from one eye to the other.

Do not allow the dropper to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

After using this medication, wait at least 5 minutes before using any other eye drops that your doctor has prescribed.

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