Lopressor HCT

DRUG DESCRIPTION

Lopressor HCT (metoprolol tartrate and hydochlorothiazide) has the antihypertensive effect of Lopressor®, metoprolol tartrate, a selective betai-adrenoreceptor blocking agent, and the antihypertensive and diuretic actions of hydrochlorothiazide. It is available as tablets for oral administration. The 50/25 tablets contain 50 mg of metoprolol tartrate USP and 25 mg of hydrochlorothiazide USP; the 100/25 tablets contain 100 mg of metoprolol tartrate USP and 25 mg of hydrochlorothiazide USP; and the 100/50 tablets contain 100 mg of metoprolol tartrate USP and 50 mg of hydrochlorothiazide USP. Metoprolol tartrate USP is (?±)-1-(Isopropylamino)-3-[p-(2-methoxyethyl)phenoxy]-2-propanol L-(+)-tartrate (2:1) salt, and its structural formula is

Metoprolol tartrate structural formula illustration

Metoprolol tartrate USP is a white, crystalline powder. It is very soluble in water; freely soluble in methylene chloride, in chloroform, and in alcohol; slightly soluble in acetone; and insoluble in ether. Its molecular weight is 684.82.

Hydrochlorothiazide is 6-chloro-3, 4-dihydro-2 H-1,2,4-benzothiadiazine-7- sulfonamide 1,1-dioxide, and its structural formula is

Hydrochlorothiazide structural formula illustration

Hydrochlorothiazide USP is a white, or practically white, practically odorless, crystalline powder. It is freely soluble in sodium hydroxide solution, in n-butylamine, and in dimethylformamide; sparingly soluble in methanol; slightly soluble in water; and insoluble in ether, in chloroform, and in dilute mineral acids. Its molecular weight is 297.73.

Inactive Ingredients: Cellulose compounds, colloidal silicon dioxide, D&C Yellow No. 10 (100/50-mg tablets), FD&C Blue No. 1 (50/25-mg tablets), FD&C Red No. 40 and FD&C Yellow No. 6 (100/25-mg tablets), lactose, magnesium stearate, povidone, sodium starch glycolate, corn starch, stearic acid, and sucrose.

What are the possible side effects of hydrochlorothiazide and metoprolol (Lopressor HCT)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • swelling, rapid weight gain, feeling short of breath, even with mild exertion;
  • fast, slow, or uneven heartbeat;
  • easy bruising or bleeding;
  • numbness or tingly feeling in your hands or feet;
  • ...

Read All Potential Side Effects and See Pictures of Lopressor HCT »

What are the precautions when taking metoprolol tartrate and hydochlorothiazide (Lopressor HCT)?

Before taking this product, tell your doctor or pharmacist if you are allergic to metoprolol or hydrochlorothiazide; or to other thiazide diuretics (such as chlorothiazide); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain types of heart rhythm problems (such as a slow heartbeat, second- or third-degree atrioventricular block, sick sinus syndrome), an inability to make urine (anuria).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood...

Read All Potential Precautions of Lopressor HCT »


Lopressor HCT Consumer (continued)

SIDE EFFECTS: See also Warning and Precautions sections.

Dizziness, lightheadedness, drowsiness, headache, slow heartbeat, tiredness, or diarrhea may occur. Decreased sexual ability has been reported infrequently. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

This product may reduce blood flow to your hands and feet, causing them to feel cold. Smoking may worsen this effect. Dress warmly and avoid tobacco use.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

The hydrochlorothiazide in this product may cause your body to lose too much water and salt (dehydration). Tell your doctor immediately if you have any of these unlikely but serious symptoms of dehydration: very dry mouth, extreme thirst, muscle cramps/weakness, fast heartbeat, severe dizziness, confusion, fainting, seizures.

Tell your doctor immediately if any of these unlikely but serious side effects occur: very slow/irregular heartbeat, mental/mood changes (such as depression, mood swings), toe/joint pain.

Tell your doctor immediately if any of these rare but very serious side effects occur: trouble breathing, blue fingers/toes, yellowing eyes/skin, persistent nausea/vomiting, severe stomach/abdominal pain, dark urine, decrease in vision, eye pain, easy bruising/bleeding, signs of infection (such as fever, persistent sore throat), change in the amount of urine (not including the normal increase in urine when you first start this drug).

Although this medication may be used to treat heart failure, some people may rarely develop new or worsening symptoms of heart failure. Tell your doctor immediately if you experience any of these unlikely but serious side effects: swelling ankles/feet, severe tiredness, shortness of breath, unexplained/sudden weight gain.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking this product, tell your doctor or pharmacist if you are allergic to metoprolol or hydrochlorothiazide; or to other thiazide diuretics (such as chlorothiazide); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain types of heart rhythm problems (such as a slow heartbeat, second- or third-degree atrioventricular block, sick sinus syndrome), an inability to make urine (anuria).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood circulation problems (such as Raynaud's disease, peripheral vascular disease), pheochromocytoma, breathing problems (such as asthma, chronic bronchitis, emphysema), overactive thyroid (hyperthyroidism), liver disease, kidney disease, lupus, serious allergic reactions including those needing treatment with epinephrine, mental/mood disorders (such as depression), gout, loss of too much body water (dehydration), untreated salt imbalance (for example, high calcium, low potassium, low magnesium), a certain muscle/nerve disease (myasthenia gravis).

Before having surgery, tell your doctor or dentist that you are taking this medication.

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

To help prevent dizziness, drink plenty of fluids while taking this medication unless your doctor directs you otherwise. Too much sweating, diarrhea, or vomiting may cause you to feel lightheaded. Report prolonged diarrhea or vomiting to your doctor.

This medication may reduce the potassium levels in your blood. Ask your doctor about adding potassium to your diet. Your doctor may prescribe a potassium supplement.

If you have diabetes, this product may prevent the fast/pounding heartbeat you would usually feel when your blood sugar level falls too low (hypoglycemia). Other symptoms of a low blood sugar level, such as dizziness and sweating, are unaffected by this drug. This product may also make it harder to control your blood sugar levels. Check your blood sugar levels regularly as directed by your doctor. Tell your doctor immediately if you have symptoms of high blood sugar such as increased thirst/urination. Your diabetes medication or diet may need to be adjusted.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.

Older adults may be more sensitive to the side effects of this drug, including dizziness.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Discuss the risks and benefits with your doctor.

Metoprolol and hydrochlorothiazide pass into breast milk, but are unlikely to harm a nursing infant. Consult your doctor before breast-feeding.


Lopressor HCT Patient Information Including Side Effects

Brand Names: Lopressor HCT

Generic Name: hydrochlorothiazide and metoprolol (Pronunciation: HYE droe klor oh THYE a zide and me TOE proe lole)

  • What is hydrochlorothiazide and metoprolol (Lopressor HCT)?
  • What are the possible side effects of hydrochlorothiazide and metoprolol (Lopressor HCT)?
  • What is the most important information I should know about hydrochlorothiazide and metoprolol (Lopressor HCT)?
  • What should I discuss with my doctor before taking hydrochlorothiazide and metoprolol (Lopressor HCT)?
  • How should I take hydrochlorothiazide and metoprolol (Lopressor HCT)?
  • What happens if I miss a dose (Lopressor HCT)?
  • What happens if I overdose (Lopressor HCT)?
  • What should I avoid while taking hydrochlorothiazide and metoprolol (Lopressor HCT)?
  • What other drugs will affect hydrochlorothiazide and metoprolol (Lopressor HCT)?
  • Where can I get more information?

What is hydrochlorothiazide and metoprolol (Lopressor HCT)?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Metoprolol is in a group of drugs called beta-blockers. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).

The combination of hydrochlorothiazide and metoprolol is used to treat high blood pressure (hypertension).

Hydrochlorothiazide and metoprolol may also be used for other purposes not listed in this medication guide.

What are the possible side effects of hydrochlorothiazide and metoprolol (Lopressor HCT)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • swelling, rapid weight gain, feeling short of breath, even with mild exertion;
  • fast, slow, or uneven heartbeat;
  • easy bruising or bleeding;
  • numbness or tingly feeling in your hands or feet;
  • feeling weak, drowsy, restless, or light-headed;
  • nausea, vomiting, dry mouth, extreme thirst, headache, confusion, hallucinations, seizure (convulsions);
  • increased urination, leg discomfort, muscle pain or weakness or limp feeling;
  • urinating less than usual or not at all;
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
  • upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • diarrhea, constipation, upset stomach;
  • dizziness, spinning sensation;
  • sore throat, body aches;
  • blurred vision; or
  • ringing in your ears.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about hydrochlorothiazide and metoprolol (Lopressor HCT)?

You should not use this medication if you have severe or uncontrolled heart failure, a heart condition called "sick sinus syndrome" or "AV block," severe blood circulation problems, an adrenal gland tumor, an allergy to beta-blockers, or if you are unable to urinate.

Before using this medication, tell your doctor if you have congestive heart failure, kidney or liver disease, cirrhosis, asthma or bronchospasm, gout, lupus, diabetes, a thyroid disorder, or if you are allergic to sulfa drugs.

If you are diabetic, check your blood sugar carefully. Using metoprolol can make it harder for you to tell when you have low blood sugar. Your insulin or diabetic medication needs may change while you are taking hydrochlorothiazide and metoprolol. Talk with your doctor before changing any doses.

Avoid drinking alcohol, which can lower your blood pressure and may add to the side effects of hydrochlorothiazide and metoprolol.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Keep taking this medication even if you feel fine. High blood pressure often has no symptoms.

There are many other medicines that can interact with hydrochlorothiazide and metoprolol. Tell your doctor about all the prescription and over-the-counter medications you use.

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