Proquad

DRUG DESCRIPTION

ProQuad (measles mumps rubella varicella vaccine live) * is a combined attenuated live virus vaccine containing measles, mumps, rubella, and varicella viruses. ProQuad (measles mumps rubella varicella vaccine live) is a sterile lyophilized preparation of (1) the components of M-M-R*ll (Measles, Mumps and Rubella Virus Vaccine Live): Measles Virus Vaccine Live, a more attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture; Mumps Virus Vaccine Live, the Jeryl Lynn™ (B level) strain of mumps vims propagated in chick embryo cell culture; Rubella Virus Vaccine Live, the Wistar RA 27/3 strain of live attenuated rubella virus propagated in WI-38 human diploid lung fibroblasts; and (2) Varicella Virus Vaccine Live (Oka/Merck), the Oka/Merck strain of varicella-zoster virus propagated in MRC-5 cells. The cells, virus pools, bovine serum, and human albumin used in manufacturing are all tested to provide assurance that the final product is free of potential adventitious agents.

ProQuad (measles mumps rubella varicella vaccine live) , when reconstituted as directed, is a sterile preparation for subcutaneous administration. Each 0.5-mL dose contains not less than 3.00 log10 TCID50 (50% tissue culture infectious dose) of measles virus; 4.30 log10 TCID50 of mumps virus; 3.00 log10 TCID50 of rubella virus; and a minimum of 3.99 log10 PFU (plaque-forming units) of Oka/Merck varicella virus.

Each 0.5-mL dose of the vaccine contains no more than 21 mg of sucrose, 11 mg of hydrolyzed gelatin, 2.4 mg of sodium chloride, 1.8 mg of sorbitol, 0.40 mg of monosodium L-glutamate, 0.34 mg of sodium phosphate dibasic, 0.31 mg of human albumin, 0.17 mg of sodium bicarbonate, 72 meg of potassium phosphate monobasic, 60 meg of potassium chloride; 36 meg of potassium phosphate dibasic; residual components of MRC-5 cells including DNA and protein; < 16 meg of neomycin, bovine calf serum (0.5 meg), and other buffer and media ingredients. The product contains no preservative.

What are the possible side effects of this vaccine (ProQuad)?

Your child should not receive a booster vaccine if he or she had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects your child has after receiving this vaccine. If the child ever needs to receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with measles, mumps, rubella, or varicella is much more dangerous to your child's health than receiving the vaccine to protect against these diseases. Like any medicine, this vaccine...

Read All Potential Side Effects and See Pictures of Proquad »

What are the precautions when taking measles mumps rubella varicella vaccine live (Proquad)?

Before your child receives this product, tell the doctor or pharmacist if your child is allergic to it; or to eggs; or if your child has any other allergies. This product may contain inactive ingredients (such as neomycin), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this product, tell the doctor or pharmacist your child's medical history, especially of: current fever/illness (such as untreated tuberculosis), bleeding/blood clotting problems (such as hemophilia, low platelets), blood cancer (such as leukemia, lymphoma), immune system problems (such as HIV infection), scheduled organ transplant, brain/nervous system disorders (such as seizures), history of Guillain-Barre syndrome.

There is a small risk...

Read All Potential Precautions of Proquad »


Proquad Consumer (continued)

SIDE EFFECTS: Pain/redness/swelling at the injection site, fever, rash, and fussiness may occur. If any of these effects persist or worsen, tell the doctor or pharmacist promptly.

Remember that the doctor has prescribed this medication because he or she has judged that the benefit to your child is greater than the risk of side effects. Many children using this medication do not have serious side effects.

Tell the doctor immediately if any of these rare but serious side effects occur: easy bruising/bleeding, joint pain/stiffness, seizures with fever.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact the doctor or pharmacist.

Contact the doctor for medical advice about side effects. The following numbers do not provide medical advice, but in the US you may report side effects to the Vaccine Adverse Event Reporting System (VAERS) at 1-800-822-7967. In Canada, you may call Health Canada at 1-866-234-2345.

PRECAUTIONS: Before your child receives this product, tell the doctor or pharmacist if your child is allergic to it; or to eggs; or if your child has any other allergies. This product may contain inactive ingredients (such as neomycin), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this product, tell the doctor or pharmacist your child's medical history, especially of: current fever/illness (such as untreated tuberculosis), bleeding/blood clotting problems (such as hemophilia, low platelets), blood cancer (such as leukemia, lymphoma), immune system problems (such as HIV infection), scheduled organ transplant, brain/nervous system disorders (such as seizures), history of Guillain-Barre syndrome.

There is a small risk that your child may expose others to infection with chickenpox for up to 6 weeks after your child has been vaccinated. If possible, your child should avoid being in the same room with newborn babies (especially if born prematurely), pregnant women who have not had chickenpox, and people with immune system problems.

This medication must not be used during pregnancy. It may harm an unborn baby. It is important to prevent pregnancy for at least 3 months after vaccination.

This medication may pass into breast milk. However, it is unlikely to harm a nursing infant. Consult the doctor before breast-feeding.


Proquad Patient Information Including Side Effects

Brand Names: ProQuad

Generic Name: measles, mumps, rubella and varicella virus vaccine (Pronunciation: MEE zels, MUMPS, roo BEL a, var i SEL a)

  • What is measles, mumps, rubella, and varicella virus vaccine (Proquad)?
  • What are the possible side effects of this vaccine (Proquad)?
  • What is the most important information I should know about this vaccine (Proquad)?
  • What should I discuss with my healthcare provider before receiving this vaccine (Proquad)?
  • How is this vaccine given (Proquad)?
  • What happens if I miss a dose (Proquad)?
  • What happens if I overdose (Proquad)?
  • What should I avoid before or after receiving this vaccine (Proquad)?
  • What other drugs will affect measles, mumps, rubella and varicella virus vaccine (Proquad)?
  • Where can I get more information?

What is measles, mumps, rubella, and varicella virus vaccine (Proquad)?

Measles, mumps, rubella, and varicella are serious diseases caused by viruses. They are spread from person to person through the air.

Measles virus can cause minor symptoms such as skin rash, cough, runny nose, eye irritation, or mild fever. It can also cause more serious symptoms such as ear infection, pneumonia, seizures, permanent brain damage, or death.

Mumps virus causes fever, headache, and swollen glands, but more serious symptoms include hearing loss, and painful swelling of the testicles or ovaries. Mumps can cause breathing problems or meningitis, and these infections can be fatal.

Rubella virus (also called German Measles) causes skin rash, mild fever, and joint pain. Becoming infected with rubella during pregnancy can result in a miscarriage or serious birth defects.

Varicella (commonly known as chickenpox) is a common childhood disease that causes fever, skin rash, and a breakout of fluid-filled blisters on the skin. Most people who receive this vaccine will not get chickenpox, or will get only a mild case and will recover faster.

Chickenpox is usually mild, but it can be serious or even fatal in young infants and in adults. It can lead to severe skin infection, breathing problems, brain damage, or death. A person who has had chickenpox can develop herpes zoster (also called shingles) later in life, which causes severe nerve pain, and hearing or vision problems, which may last for months or years.

Measles, mumps, rubella, and varicella are spread from person to person.

The measles, mumps, rubella, and varicella vaccine is used to help prevent these diseases in children.

This vaccine works by exposing your child to a small dose of the virus or a protein from the virus, which causes the body to develop immunity to the disease. This vaccine will not treat an active infection that has already developed in the body.

Measles, mumps, rubella, and varicella vaccine is for use in children between the ages of 12 months and 12 years old.

Like any vaccine, the measles, mumps, rubella, and varicella vaccine may not provide protection from disease in every person.

What are the possible side effects of this vaccine (Proquad)?

Your child should not receive a booster vaccine if he or she had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects your child has after receiving this vaccine. If the child ever needs to receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with measles, mumps, rubella, or varicella is much more dangerous to your child's health than receiving the vaccine to protect against these diseases. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

Get emergency medical help if your child has any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if your child has any of these serious side effects:

  • problems with hearing or vision;
  • extreme drowsiness, fainting;
  • fussiness, irritability, crying for an hour or longer;
  • easy bruising or bleeding, unusual weakness;
  • seizure (black-out or convulsions); or
  • high fever (within a few hours or a few days after the vaccine).

Less serious side effects include:

  • redness, pain, swelling, or a lump where the shot was given;
  • headache, dizziness;
  • low fever;
  • joint or muscle pain; or
  • nausea, vomiting, diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.

What is the most important information I should know about this vaccine (Proquad)?

The measles, mumps, rubella , and varicella vaccine is usually given only once when the child is between 12 months and 12 years old. If a booster dose is needed, At least 3 months should pass between the first and second doses of this vaccine.

Your child can still receive a vaccine if he or she has a cold or fever. In the case of a more severe illness with a fever or any type of infection, wait until the child gets better before receiving this vaccine.

Your child should not receive a booster vaccine if he or she had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects your child has after receiving this vaccine. If the child ever needs to receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with measles, mumps, rubella, or varicella is much more dangerous to your child's health than receiving the vaccine to protect against these diseases. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

Do not give your child salicylates such as aspirin, Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others for at least 6 weeks after receiving this vaccine. A serious condition called Reye's Syndrome has been reported in patients with chickenpox who take aspirin or salicylates.

Related Drug Centers
  • Proquad


Related Drugs Index: