Menactra

DRUG DESCRIPTION

Menactraź, Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine, is a sterile, intramuscularly administered vaccine that contains Neisseria meningitidis serogroup A, C, Y and W-135 capsular polysaccharide antigens individually conjugated to diphtheria toxoid protein. N meningitidis A, C, Y and W-135 strains are cultured on Mueller Hinton agar1 and grown in Watson Scherp2 media. The polysaccharides are extracted from the N meningitidis cells and purified by centrifugation, detergent precipitation, alcohol precipitation, solvent extraction and diafiltration. To prepare the polysaccharides for conjugation, they are depolymerized, derivatized, and purified by diafiltration. Corynebacterium diphtheriae cultures are grown in a modified Mueller and Miller medium3 and detoxified with formaldehyde. The diphtheria toxoid protein is purified by ammonium sulfate fractionation and diafiltration. The derivatized polysaccharides are covalently linked to diphtheria toxoid and purified by serial diafiltration. The four meningococcal components, present as individual serogroup- specific glycoconjugates, compose the final formulated vaccine. No preservative or adjuvant is added during manufacture. Potency of Menactra (polysaccharide diphtheria toxoid conjugate vaccine) vaccine is determined by quantifying the amount of each polysaccharide antigen that is conjugated to diphtheria toxoid protein and the amount of unconjugated polysaccharide present.

Menactra (polysaccharide diphtheria toxoid conjugate vaccine) vaccine is manufactured as a sterile, clear to slightly turbid liquid. Each 0.5 mL dose of vaccine is formulated in sodium phosphate buffered isotonic sodium chloride solution to contain 4 ?”g each of meningococcal A, C, Y, and W-135 polysaccharides conjugated to approximately 48 ?”g of diphtheria toxoid protein carrier.

What are the possible side effects of meningococcal conjugate vaccine (Menactra)?

Keep track of any and all side effects you have after receiving this vaccine. If you ever have to receive another meningococcal vaccine in the future, you will need to tell the doctor if the first shot caused any side effects.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • severe weakness or unusual feeling in your...

Read All Potential Side Effects and See Pictures of Menactra »

What are the precautions when taking polysaccharide diphtheria toxoid conjugate vaccine (Menactra)?

Before receiving this vaccine, tell your doctor or pharmacist if you are allergic to it; or to latex; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccination, tell your doctor or pharmacist your medical history, especially of: current fever/illness, a certain nerve disease (Guillain-Barre syndrome), bleeding disorders (such as hemophilia, thrombocytopenia).

This vaccine can cause some patients to faint, which could cause falling and injury. To reduce the risk of this side effect, your doctor may recommend that you stay in a sitting or lying position for 15 minutes after the injection. Infrequently, fainting along with...

Read All Potential Precautions of Menactra »

What are the possible side effects of meningococcal conjugate vaccine (Menactra)?

Keep track of any and all side effects you have after receiving this vaccine. If you ever have to receive another meningococcal vaccine in the future, you will need to tell the doctor if the first shot caused any side effects.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • severe weakness or unusual feeling in your...

Read All Potential Side Effects and See Pictures of Menactra »

What are the precautions when taking polysaccharide diphtheria toxoid conjugate vaccine (Menactra)?

Before receiving this vaccine, tell your doctor or pharmacist if you are allergic to it; or to latex; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccination, tell your doctor or pharmacist your medical history, especially of: current fever/illness, a certain nerve disease (Guillain-Barre syndrome), bleeding disorders (such as hemophilia, thrombocytopenia).

This vaccine can cause some patients to faint, which could cause falling and injury. To reduce the risk of this side effect, your doctor may recommend that you stay in a sitting or lying position for 15 minutes after the injection. Infrequently, fainting along with...

Read All Potential Precautions of Menactra »

What are the possible side effects of meningococcal conjugate vaccine (Menactra)?

Keep track of any and all side effects you have after receiving this vaccine. If you ever have to receive another meningococcal vaccine in the future, you will need to tell the doctor if the first shot caused any side effects.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • severe weakness or unusual feeling in your...

Read All Potential Side Effects and See Pictures of Menactra »

What are the precautions when taking polysaccharide diphtheria toxoid conjugate vaccine (Menactra)?

Before receiving this vaccine, tell your doctor or pharmacist if you are allergic to it; or to latex; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccination, tell your doctor or pharmacist your medical history, especially of: current fever/illness, a certain nerve disease (Guillain-Barre syndrome), bleeding disorders (such as hemophilia, thrombocytopenia).

This vaccine can cause some patients to faint, which could cause falling and injury. To reduce the risk of this side effect, your doctor may recommend that you stay in a sitting or lying position for 15 minutes after the injection. Infrequently, fainting along with...

Read All Potential Precautions of Menactra »

What are the possible side effects of meningococcal conjugate vaccine (Menactra)?

Keep track of any and all side effects you have after receiving this vaccine. If you ever have to receive another meningococcal vaccine in the future, you will need to tell the doctor if the first shot caused any side effects.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • severe weakness or unusual feeling in your...

Read All Potential Side Effects and See Pictures of Menactra »

What are the precautions when taking polysaccharide diphtheria toxoid conjugate vaccine (Menactra)?

Before receiving this vaccine, tell your doctor or pharmacist if you are allergic to it; or to latex; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccination, tell your doctor or pharmacist your medical history, especially of: current fever/illness, a certain nerve disease (Guillain-Barre syndrome), bleeding disorders (such as hemophilia, thrombocytopenia).

This vaccine can cause some patients to faint, which could cause falling and injury. To reduce the risk of this side effect, your doctor may recommend that you stay in a sitting or lying position for 15 minutes after the injection. Infrequently, fainting along with...

Read All Potential Precautions of Menactra »

What are the possible side effects of meningococcal conjugate vaccine (Menactra)?

Keep track of any and all side effects you have after receiving this vaccine. If you ever have to receive another meningococcal vaccine in the future, you will need to tell the doctor if the first shot caused any side effects.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • severe weakness or unusual feeling in your...

Read All Potential Side Effects and See Pictures of Menactra »

What are the precautions when taking polysaccharide diphtheria toxoid conjugate vaccine (Menactra)?

Before receiving this vaccine, tell your doctor or pharmacist if you are allergic to it; or to latex; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccination, tell your doctor or pharmacist your medical history, especially of: current fever/illness, a certain nerve disease (Guillain-Barre syndrome), bleeding disorders (such as hemophilia, thrombocytopenia).

This vaccine can cause some patients to faint, which could cause falling and injury. To reduce the risk of this side effect, your doctor may recommend that you stay in a sitting or lying position for 15 minutes after the injection. Infrequently, fainting along with...

Read All Potential Precautions of Menactra »


Menactra Consumer (continued)

SIDE EFFECTS: Pain/redness/swelling at the injection site, headache, tiredness, joint pain, loss of appetite, chills, fever, and diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these rare but serious side effects occur: numbness/tingling of arms/legs, muscle weakness.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Contact your doctor for medical advice about side effects. The following numbers do not provide medical advice, but in the US, you may report side effects to the Vaccine Adverse Event Reporting System (VAERS) at 1-800-822-7967. In Canada, you may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before receiving this vaccine, tell your doctor or pharmacist if you are allergic to it; or to latex; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccination, tell your doctor or pharmacist your medical history, especially of: current fever/illness, a certain nerve disease (Guillain-Barre syndrome), bleeding disorders (such as hemophilia, thrombocytopenia).

This vaccine can cause some patients to faint, which could cause falling and injury. To reduce the risk of this side effect, your doctor may recommend that you stay in a sitting or lying position for 15 minutes after the injection. Infrequently, fainting along with seizure-like movements have occurred, and have usually been stopped by placing the patient in a lying position with the face up.

During pregnancy, this vaccine should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.


Menactra Patient Information Including Side Effects

Brand Names: Menactra

Generic Name: meningococcal conjugate vaccine (Pronunciation: me NIN je KOK al KON je gate vax EEN)

  • What is meningococcal conjugate vaccine (Menactra)?
  • What are the possible side effects of meningococcal conjugate vaccine (Menactra)?
  • What is the most important information I should know about meningococcal conjugate vaccine (Menactra)?
  • What should I discuss with my healthcare provider before receiving meningococcal conjugate vaccine (Menactra)?
  • How is meningococcal conjugate vaccine given (Menactra)?
  • What happens if I miss a dose (Menactra)?
  • What happens if I overdose (Menactra)?
  • What should I avoid before or after getting meningococcal conjugate vaccine (Menactra)?
  • What other drugs will affect meningococcal conjugate vaccine (Menactra)?
  • Where can I get more information?

What is meningococcal conjugate vaccine (Menactra)?

Meningococcal disease is a serious infection caused by a bacteria. Meningococcal bacteria can infect the blood, spinal cord, and brain. These conditions can be fatal.

Meningococcal disease can spread from one person to another through small droplets of saliva that are expelled into the air when an infected person coughs or sneezes. The bacteria can also be passed through contact with objects the infected person has touched, such as a door handle, or other surface. The bacteria can also be passed through kissing, or sharing a drinking glass or eating utensil with an infected person.

Meningococcal conjugate vaccine is used to prevent infection caused by meningococcal bacteria. The vaccine contains four of the most common types of meningococcal bacteria.

Meningococcal conjugate vaccine works by exposing you to a small dose of the bacteria or a protein from the bacteria, which causes your body to develop immunity to the disease. This vaccine will not treat an active infection that has already developed in the body.

Meningococcal conjugate vaccine is for use in children and adults between the ages of 2 and 55 years old.

Like any vaccine, meningococcal conjugate vaccine may not provide protection from disease in every person.

Becoming infected with meningitis (infection of the spinal cord and lining of the brain) is much more dangerous to your health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low.

What are the possible side effects of meningococcal conjugate vaccine (Menactra)?

Keep track of any and all side effects you have after receiving this vaccine. If you ever have to receive another meningococcal vaccine in the future, you will need to tell the doctor if the first shot caused any side effects.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • severe weakness or unusual feeling in your arms and legs (may occur 2 to 4 weeks after you receive the vaccine);
  • high fever; or
  • unusual bleeding.

Less serious side effects may be more likely to occur, such as:

  • low fever, chills;
  • redness, pain, swelling, or a lump where the vaccine was injected;
  • headache, weakness, tired feeling;
  • joint pain;
  • diarrhea;
  • vomiting, loss of appetite; or
  • mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.

What is the most important information I should know about meningococcal conjugate vaccine (Menactra)?

Becoming infected with meningitis is much more dangerous to your health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low.

Keep track of any and all side effects you have after receiving this vaccine. If you ever need to receive another meningococcal vaccine in the future, you will need to tell the doctor if the first shot caused any side effects.

Do not receive this vaccine if you have ever had an allergic reaction to a meningococcal or a diphtheria vaccine, if you are allergic to latex rubber, or if you have a history of Guillain-Barre syndrome.

Before receiving meningococcal conjugate vaccine, tell your doctor if you have a bleeding or blood clotting disorder, a weak immune system, or if you are receiving steroids, chemotherapy, or radiation treatment. If you have any of these conditions, your vaccine may need to be postponed or not given at all.

You can still receive a meningococcal conjugate vaccine if you have a minor cold. However, if you are moderately or severely ill with a fever or any type of infection, wait until you recover before receiving this vaccine.

Like any vaccine, meningococcal conjugate vaccine may not provide protection from disease in every person.

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