Matulane

DRUG DESCRIPTION

Matulane (procarbazine hydrochloride), a hydrazine derivative antineoplastic agent, is available as capsules containing the equivalent of 50 mg procarbazine as the hydrochloride. Each capsule also contains cornstarch, mannitol and talc. Gelatin capsule shells contain parabens (methyl and propyl), potassium sorbate, titanium dioxide, FD&C Yellow No. 6 and D&C Yellow No. 10.

Chemically, procarbazine hydrochloride is N-isopropyl-?-(2-methylhydrazino)-p-toluamide monohydrochloride. It is a white to pale yellow crystalline powder which is soluble but unstable in water or aqueous solutions. The molecular weight of procarbazine hydrochloride is 257.76 and the structural formula is:

Matulane (procarbazine hydrochloride)  structural formula illustration

What are the possible side effects of procarbazine (Matulane)?

If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (shortness of breath; closing of your throat; difficulty breathing; swelling of your lips, face, or tongue; or hives);
  • decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection);
  • numbness, tingling, or confusion;
  • any sore in or around the...

Read All Potential Side Effects and See Pictures of Matulane

What are the precautions when taking procarbazine (Matulane)?

Before taking procarbazine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: history of alcohol use.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart/blood vessel problems, recent chickenpox, shingles (Herpes zoster), diabetes, seizures, liver disease, kidney disease, severe/frequent headaches, current infection, overactive thyroid (hyperthyroidism), current or past tobacco use,...

Read All Potential Precautions of Matulane


Matulane Consumer (continued)

SIDE EFFECTS: Nausea, vomiting, loss of appetite, constipation, dry mouth, difficulty swallowing, drowsiness, dizziness, headache, trouble sleeping, muscle/joint pain, or darkening of the skin may occur. Nausea and vomiting can be severe. In some cases, drug treatment may be needed to prevent or relieve nausea and vomiting. Not eating before your treatment may help relieve vomiting. Changes in diet and lifestyle, such as eating several small meals and limiting activity, may help lessen some of these effects. If any of these effects continue or worsen, tell your doctor or pharmacist.

Temporary hair loss may occur. Normal hair growth should return several months after treatment has ended.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Some people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: black/bloody stools, bloody/pink urine, vomit that is bloody or looks like coffee grounds, stomach pain, yellowing eyes/skin, unsteadiness, fainting.

Seek immediate medical attention if any of these unlikely but very serious side effects occur: chest pain, vision problems, fast or slow heartbeat, severe headache, seizures, stiff/sore neck, increased sweating (with or without fever), cold/clammy skin, mental/mood changes, tingling/numbness of hands/feet, unusual bleeding/bruising, diarrhea, mouth/lip sores.

This medication can lower your body's ability to fight an infection. Tell your doctor if you develop any signs of an infection such as: fever, sore throat, chills, unusual tiredness, lower back or side pain, difficult urination, cough, breathing difficulty, thick mucus/phlegm.

Very rarely, people with cancer who are treated with this type of medication have developed other cancers (e.g., secondary leukemia). Your risk is greater if you have received certain types of chemotherapy or radiation therapy. Consult your doctor for more details.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking procarbazine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: history of alcohol use.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart/blood vessel problems, recent chickenpox, shingles (Herpes zoster), diabetes, seizures, liver disease, kidney disease, severe/frequent headaches, current infection, overactive thyroid (hyperthyroidism), current or past tobacco use, radiation therapy, blood diseases (e.g., bone marrow depression, low platelet counts).

Avoid alcoholic beverages or alcohol-containing products/foods (e.g., cough and cold syrups, mouthwash, aftershave, sauces, vinegars) while taking this medication. When procarbazine is combined with alcohol, a severe reaction (disulfiram/alcohol-like reaction) may occur, with symptoms such severe nausea, vomiting, flushing, blurred vision, headache, dizziness, severe tiredness, difficulty breathing, fast/pounding heartbeat, increased sweating, or seizures. Contact your doctor immediately if you drink alcohol or have any of the above symptoms while taking procarbazine.

Avoid smoking while using this medication. Smoking increases the risk of developing lung cancer while using this drug. Consult your doctor or pharmacist for more details.

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Before having surgery or emergency treatment, tell the doctor or dentist that you have been receiving this medication.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.

To lower the chance of getting cut, bruised or injured, use caution with sharp objects like safety razors and nail cutters, and avoid activities such as contact sports.

Wash your hands well and often to prevent the spread of infections. Also, avoid touching your eyes or inside your nose without first washing your hands.

Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose.

Caution is advised when using this drug in children because they may be more sensitive to its effects, especially the risk of shaking (tremors), loss of consciousness, or seizures.

This medication is not recommended for use during pregnancy. It may harm an unborn baby. It is recommended that men and women use 2 effective forms of birth control (e.g., condoms and birth control pills) while being treated with this medication and for some time afterward. Consult your doctor for more details and to discuss reliable forms of birth control.

It is not known whether this drug passes into breast milk. Because this drug may harm a nursing infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.


Matulane Patient Information Including Side Effects

Brand Names: Matulane

Generic Name: procarbazine (Pronunciation: pro CAR bah zeen)

  • What is procarbazine (Matulane)?
  • What are the possible side effects of procarbazine (Matulane)?
  • What is the most important information I should know about procarbazine (Matulane)?
  • What should I discuss with my healthcare provider before taking procarbazine (Matulane)?
  • How should I take procarbazine (Matulane)?
  • What happens if I miss a dose (Matulane)?
  • What happens if I overdose (Matulane)?
  • What should I avoid while taking procarbazine (Matulane)?
  • What other drugs will affect procarbazine (Matulane)?
  • Where can I get more information?

What is procarbazine (Matulane)?

Procarbazine is a cancer (antineoplastic) medication. Procarbazine interferes with the growth of cancer cells and slows their growth and spread in the body.

Procarbazine is used to treat Hodgkin's Disease (a type of blood cancer).

Procarbazine may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of procarbazine (Matulane)?

If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (shortness of breath; closing of your throat; difficulty breathing; swelling of your lips, face, or tongue; or hives);
  • decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection);
  • numbness, tingling, or confusion;
  • any sore in or around the mouth; or
  • diarrhea or watery stools.

Other less serious side effects may be more likely to occur. Talk to your doctor if you experience:

  • temporary hair loss;
  • itching or rash;
  • nausea, vomiting, or weight loss;
  • dizziness;
  • vision or eye problems;
  • increased urination;
  • muscle or joint pain;
  • nervousness, depression, or nightmares;
  • hearing problems;
  • fatigue.

In some cases, second cancers have been reported to occur during and following treatment with procarbazine. Procarbazine may also affect egg production in women and sperm production in men. Talk to your doctor about the risks and benefits of this medication.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about procarbazine (Matulane)?

Procarbazine should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Serious side effects have been reported with the use of procarbazine including: allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; fever or chills; or signs of infection such as fever; chills, or sore throat); nervous system side effects (numbness, tingling, or confusion); sore in or around the mouth; and diarrhea. Talk to your doctor about the possible side effects from treatment with procarbazine.

Avoid alcohol, chocolate, and all of the foods listed in the "What should I avoid while taking procarbazine?" section of this leaflet. Foods high in tyramine can cause a severe reaction, including a severe headache, large pupils, neck stiffness, nausea, vomiting, sweating, irregular heartbeats, and chest pain. Call your doctor immediately if you experience any of the symptoms listed above.

Procarbazine may interact with many other medications, sometimes resulting in serious side effects. Do not take any other prescription or over-the-counter medicines, including herbal products, during treatment with procarbazine without first talking to your doctor.

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